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612.P1.22 Acute Lymphocytic Leukemia - Biology and Pathophysiology Poster II

Sunday, December 7, 2008: 6:00 PM-8:00 PM
Hall A (Moscone Center)
Implications for the Use of Monoclonal Antibodies in Future Adult ALL Trials: Analysis of Antigen Expression in 505 B-Lineage (B-Lin) ALL Patients (pts) on the MRC UKALLXII/ECOG2993 Intergroup Trial

Elisabeth Paietta, Ph.D.1, Xiaochun Li, Ph.D.2*, Sue Richards3*, Janis Racevskis, Ph.D.1*, Gordon W. Dewald, PhD, PhD, FACMG4, Jacob M. Rowe, MD5, Martin S Tallman6, Hillard M Lazarus, MD7*, Mark Litzow, M.D.4*, Anthony H. Goldstone, FRCP, FRCPath8 and Peter H. Wiernik, MD1*

1Cancer Center, Montefiore Medical Center North Division, Bronx, NY
2Division of Biostatistics, Indiana University, Indianapolis, IN
3Ctsu, University of Oxford, Oxford, United Kingdom
4Mayo Clinic, Rochester, MN
5Hematology and Bone Marrow Transplantation, Rambam Health Care Campus and Technion, Israel Institute of Technology, Haifa, Israel., Haifa, Israel
6Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL
7Ireland Cancer Center, University Hospitals of Cleveland, Cleveland, OH
8Univ. College London Hosp., London, ARRAY(0xc1581ac)

Genetic Polymorphisms of β-Cell Differentiation Confer Risk of Alterations of Glucose Metabolism in Survivors of Childhood Acute Lymphoblastic Leukemia

Pacharapan Surapolchai, MD1*, Suradej Hongeng, MD1, Pat Mahachoklertwattana1*, Samart Pakakasama, MD1, Angkana Winaichatsak, MD2*, Nittaya Wisanuyothin2*, Ekawat Pasomsub3*, Surakameth Mahasirimongkol, MD4* and Nongnuch Sirachainan1*

1Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Bangkok, Thailand
2Pediatrics, Maharaj Nakhonratchasima Hospital, Nakhonratchasima, Thailand
3Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Bangkok, Thailand
4Department of Medical Science, National Institute of Health, Nondhaburi, Thailand

Obesity Accelerates T-Cell Leukemia in a Spontaneous Mouse Model

Jason P Yun1*, Lars Klemm2*, James W Behan1*, Markus Müschen, MD, PhD3 and Steven D Mittelman, MD, PhD1*

1Division of Endocrinology, Childrens Hospital Los Angeles, Los Angeles, CA
2Hematology/Oncology, Childrens Hospital Los Angeles, Los Angeles, CA
3Childrens Hospital Los Angeles, Los Angeles, CA

The Multikinase Inhibitor Sorafenib Inhibts Proliferation in B- and T-Lymphoblastic Cell Lines Via the PI3K/Akt Pathway

Catrin Schult1*, Meike Dahlhaus1*, Sonja Boldt2*, Änne Glass3*, Sabine Ruck1*, Mandy Sawitzky1*, Sandra Lange1*, Francesca Amoroso1*, Mathias Freund1, Luca Maria Neri4* and Christian Junghanss1*

1Hematology/Oncology, University of Rostock, Rostock, Germany
2Systems Biology & Bioinformatics Group, University of Rostock, Rostock, Germany
3Institute for Medical Informatics and Biometry, University of Rostock, Rostock, Germany
4Morphology and Embryology, University of Ferrara, Ferrara, Italy

PI3 Kinase Inhibition Induces Apoptotic Cell Death in Acute Lymphoblastic Leukemia Via the Mitochondrial Pathway

Karin von Schwarzenberg1*, Marco Henkel2*, Dennis Conzelmann3*, Björn Stork2*, Anita Bringmann1*, Sebastian Wesselborg2* and Peter Brossart, MD1

1Hem./Onc., Univ. of Bonn, Bonn, Germany
2Gastroenterology, University of Tuebingen, Tuebingen, Germany
3Hematology, Oncology, Immunology, Rheumatology and Pulmology, University of Tuebingen, Tuebingen, Germany

Tumor Necrosis Factor-α Contributes to Microenvironmental up-Regulation of NF-κB Activity in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Implication for a Novel Therapeutic Target

Hui-Jen Tsai, MD1, Seiichiro Kobayashi, MD, PhD2*, Kiyoko Itoh, PhD2*, Takaomi Ishida, PhD3*, Kazuo Umezawa, PhD4* and Arinobu Tojo, MD, PhD2

1Hem. Onc., Kaohsiung Med. Univ. Hosp., Kaohsiung, Taiwan
2Div of Molecular Therapy, Institute of Medical Science, Univ. of Tokyo, Tokyo, Japan
3Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan
4Faculty of Science and Technology, Keio University, Yokohama-shi, Japan

Rearranged Infant Acute Lymphoblastic Leukemia

Ronald W. Stam, PhD1*, Monique L. Den Boer, PhD1, Pauline Schneider1*, Jasper de Boer, PhD2*, Jill Hagelstein, MSc1*, Stephen E. Sallan, MD3, Hugh J.M. Brady, PhD2*, Scott Armstrong, MD, PhD3* and Rob Pieters, MD, PhD1

1Pediatric Oncology/Hematology, Erasmus MC - Sophia Children's Hospital, Rotterdam, Netherlands
2Molecular Haematology and Cancer Biology Unit, UCL Institute of Child Health and Great Ormond Street Hospital, London, United Kingdom
3Dana-Farber Cancer Institute, Boston, MA

Mir-128b Is a Potent Glucocorticoid Sensitizer in MLL-AF4 Acute Lymphocytic Leukemia Cells and Exerts Synergistic Effects with Mir-221

Ai Kotani1*, Daon Ha2*, Prakash Rao1*, James Hsieh3*, Diana Schotte4*, Monique L. den Boer4*, Scott Armstrong, MD, PhD5 and Harvey F. Lodish, PhD1

1Whitehead Institute for Biomedical Research, Cambridge, MA
2Biology, MIT, Cambridge
3Washington University, St. Louis
4Erasmus MC/Sophia Children's Hospital, Rotterdam, Netherlands
5Children's Hospital, Boston, MA

Different Roles of Two Autotaxin Isoforms in Proliferation, Migration and Adhesion in the Non-Mutational Tyrosine Kinase Inhibitor Resistant Acute Lymphoblastic Leukemia Cell Line SupB15

Aline Schmidt-Tanguy, MD1*, Annette Romanski, PhD1*, Mathilde Hunault-Berger, MD, PhD2* and Oliver G. Ottmann, MD3

1Hematology, J.W. Goethe University, Frankfurt am Main, Germany
2Service des Maladies du Sang, CHU Angers, Angers, France
3Goethe University, Frankfurt, Germany

CXCR7 Is Expressed in B Acute Lymphoblastic Leukemia (ALL) Cells and Mediates Their Transendothelial Migration

Ali Jalili, PhD, MSc1*, Neeta Shirvaikar, MSc2*, Imran Mirza, FRCPC3, Sara Ilnitsky2*, Mark Penfold, PhD4*, Thomas J Schall, PhD5* and Anna Janowska-Wieczorek, MD, PhD6

1Div. Clinical Hematology, Medicine, University of Alberta, Edmonton, AB, Canada
2Research and Development, Canadian Blood Services, Edmonton, AB, Canada
3University of Alberta, Edmonton, AB, Canada
4ChemoCentryx, Inc., Mountain View, CA
5ChemoCentryx, Inc, Mountain View, CA
6Div. Clinical Hematology, Dept. of Medicine, University of Alberta, Edmonton, AB, Canada

Select  γ-Secretase Inhibitors Induce Apoptosis in Pre-B ALL Cells and Disrupt the Balance Between Constitutive Notch Signaling and Repression

Bridget S. Wilson, PhD1*, Xiangbing Meng, MD1*, Tomas Mazel, MD/PhD1*, Cheryl L. Willman, MD1, Susan Atlas, PhD1*, Richard Harvey, PhD1*, I-Ming Chen, MD1*, Stephen P. Hunger, MD2, Janet M Oliver, PhD1* and Stuart S. Winter, MD1*

1University of New Mexico Cancer Center, Albuquerque, NM
2University of Colorado Denver School of Medicine and The Children's Hospital, Aurora, CO

The Pre-B Cell Receptor Suppresses Leukemogenesis by Censoring MYC-Expression

Rahul Nahar1*, Daniel Trageser1*, Lars Klemm1*, Cihangir Duy1*, Peter van Essen1*, Yong-mi Kim1*, Nora Heisterkamp1*, Giovanni Martinelli2*, Wolf-Karsten Hofmann, MD3*, Hans-Martin Jack4*, Hassan Jumaa5* and Markus Muschen1

1Leukemia Research Program, Childrens Hospital Los Angeles, Los Angeles, CA
2Department of Hematology/Oncology “L. and A. Seràgnoli”, University of Bologna, Italy
3MILE Study Group, on Behalf of European LeukemiaNet (ELN, WP13), Munich, Germany
4Molecular Immunology, University of Erlangen, Erlangen, Germany
5Molecular Immunology, Max-Planck-Institute for Immunology, Freiburg, Germany

*signifies non-member of ASH