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611.O2.6 Acute Leukemias – DNA Copy Number Alterations

Monday, December 8, 2008: 1:30 PM-3:00 PM
Yerba Buena Ballroom Salon 9 (San Francisco Marriott)
Moderators:
Susana C. Raimondi, PhD and Marilyn L. Slovak, PhD
1:30 PM
Deletion of IKZF1 (Ikaros) Predicts Poor Outcome and Impaired Maturation in B-Progenitor Acute Lymphoblastic LeukemiaClinically Relevant Abstract

Charles G. Mullighan, MBBS(Hons), MSc, MD1, Xiaoping Su, PhD1*, Jinghui Zhang, PhD2*, Ina Radtke, PhD1*, Letha A Phillips, BS1*, Christopher B Miller, BS1*, Jing Ma, PhD3*, Wei Liu, PhD4*, Cheng Cheng, PhD4*, Richard C. Harvey, PhD5*, I-Ming Chen, DVM, MS5*, Robert Clifford, PhD6*, William L. Carroll, MD7, Gregory Reaman, MD8, Meenakshi Devidas, PhD9*, Daniela S. Gerhard, Ph.D.10*, Wenjian Yang, PhD11*, W. Paul Bowman12*, Sheila A. Shurtleff, PhD1*, Mary V. Relling, Pharm, D11*, Malcolm Smith, MD, PhD13*, Stephen P. Hunger, MD14, Cheryl L. Willman, MD5 and James R. Downing, MD1*

1Pathology, St. Jude Children's Research Hospital, Memphis, TN
2Center for Biomedical Informatics and Information Technology, NCI/NIH, Rockville, MD
3Hartwell Center, St. Jude Children's Research Hospital, Memphis, TN
4Biostatistics, St. Jude Children's Research Hospital, Memphis, TN
5University of New Mexico Cancer Center, Albuquerque, NM
6Laboratory of Population Genetics, NCI/NIH, Rockville, MD
7New York University Cancer Institute, New York, NY
8Children's National Med. Ctr., Washington, DC
9Children's Oncology Group and University of Florida, Gainesville, FL
10National Cancer Institute, Bethesda, MD
11Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN
12Hematology-Oncology, Cook Childrens Medical Center, Fort Worth, TX
13Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD
14University of Colorado Denver School of Medicine and The Children's Hospital, Aurora, CO

1:45 PM
Identification and Molecular Characterization of Two Recurrent Genomic Deletions (Type A and Type B) on 7p12 in IKZF1 Gene in a Large Cohort of BCR-ABL1-Positive Acute Lymphoblastic Leukemia (ALL): on Behalf of the GIMEMA ALL Working Party

Ilaria Iacobucci, PhD1*, Clelia Tiziana Storlazzi2*, Emanuela Ottaviani1*, Annalisa Lonetti1*, Anna Ferrari1*, Sabina Chiaretti3*, Monica Messina3*, Daniela Cilloni4*, Nicoletta Testoni1*, Cristina Papayannidis1*, Francesca Messa5*, Annalisa Astolfi6*, Luciana Impera2*, Antonella Vitale3*, Francesca Arruga5*, Fabrizio Pane7, Pier Paolo Piccaluga1, Pietro D'Addabbo2*, Sabrina Colarossi1*, Simona Soverini1*, Marco Vignetti8*, Francesca Paoloni8*, Stefania Paolini1*, Giuseppe Saglio5*, Michele Baccarani1*, Robert Foà3 and Giovanni Martinelli1

1Department of Hematology/Oncology L. and A. Seràgnoli, University of Bologna, Bologna, Italy
2University of Bari, Department of Genetics and Microbiology, Bari, Italy
3“Sapienza” University of Rome, Dept. of Cellular Biotechnologies and Hematology, Rome, Italy
4Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy
5Department of Clinical and Biological Science, University of Turin at Orbassano, Orbassano, Turin, Italy
6Paediatric Oncology and Haematology Unit, University of Bologna, Bologna, Italy
7CEINGE Biotecnologie Avanzate, University of Naples Federico II, Naples, Italy
8GIMEMA Data Center, GIMEMA Foundation, Rome, Italy

2:00 PM
Genomic Analysis of the Clonal Origins of Relapsed Acute Lymphoblastic Leukemia

Charles G Mullighan, MBBS(Hons), MSc, MD1, Letha A Phillips, BS1*, Xiaoping Su, PhD1*, Jing Ma, PhD2*, Christopher B Miller, BS1* and James R. Downing, MD1*

1Pathology, St. Jude Children's Research Hospital, Memphis, TN
2Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital, Memphis, TN

2:15 PM
The Spectrum and Prognostic Relevance of Additional Abnormalities, Involving 12p and 21q, in Children with ETV6-RUNX1 Positive Acute Lymphoblastic Leukaemia (ALL)

Anthony V Moorman1, Zoe J Konn2*, Kerry E Barber2*, Sarah L Wright2*, Adam RM Stewart2*, Helen Parker2*, Sue M Richards3*, Sally E Kinsey4, Osborn B Eden5*, Ajay J Vora6, Christopher D Mitchell7*, Jonathan C Strefford2* and Christine J Harrison1

1Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, United Kingdom
2Cancer Sciences Division, University of Southampton, Southampton, United Kingdom
3Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom
4St. James' Univ. Hospital, Leeds, United Kingdom
5Department of Paediatric Oncology, Central Manchester and Manchester Children's University Hospitals Trust, Manchester, United Kingdom
6Dept. of Pediatric Hematology, The Children's Hospital, Sheffield, United Kingdom
7Department of Paediatric Oncology, John Radcliffe Hospital, Oxford, United Kingdom

2:30 PM
Chromosomal defects Detected by SNP-Array-Based Karyotyping Are Independent Predictors of Survival in Acute Myeloid Leukemia (AML)

Ramon V. Tiu, MD, BS1, Lukasz P Gondek, MD2*, Bhavana Bhatnagar, DO2*, Christine O'Keefe, PhD1*, Mikkael A. Sekeres, MD, MS3, Xiao-Fei Wang, MD, PhD4*, Mark J. Levis, MD, PhD4, Michael A McDevitt, MD, PhD4, Judith E. Karp, MD4 and Jaroslaw P. Maciejewski, MD, PhD1

1Hematologic Oncology and Blood Disorders/Experimental Hematology, Cleveland Clinic, Cleveland, OH
2Internal Medicine, Cleveland Clinic, Cleveland, OH
3Hematologic Oncology and Blood Disorders, Cleveland Clinic, Cleveland, OH
4Johns Hopkins University School of Medicine, Baltimore, MD

2:45 PM
A Genome-Wide Analysis to Identify Novel Susceptibility Loci for Therapy-Related Acute Myeloid Leukemia

Kenan Onel, MD, PhD1, Jeffrey A Knight1*, Andrew D Skol, PhD2*, Thelma R Tennant3*, Mekhala Banerjee2*, Richard Walgren, MD, PhD4*, Jin Shao4*, James M Allan, MD5*, Michelle M Le Beau, PhD2, Richard A Larson, MD2, Timothy Graubert, MD4 and Nancy J Cox, PhD2*

1Pediatrics, University of Chicago, Chicago, IL
2Medicine, University of Chicago, Chicago, IL
3University of Chicago, Chicago, IL
4Medicine, Washington University, St Louis, MO
5Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom

*signifies non-member of ASH