50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Mechanism of Drug Action And New Targets

Monday, December 8, 2008: 11:00 AM-12:30 PM

Yerba Buena Ballroom Salon 8 (San Francisco Marriott)

Moderators:

John C. Byrd and Preet Chaudhary, MD, PhD

11:00 AM

Clofarabine Induces Hypomethylation of DNA and Expression of Cancer-Testis Antigens

Yana Zhang, MD, PhD¹^*, Jian Zhang, BA¹^*, Masum Shahriar, MSc¹^* and Seah H. Lim, MD, PhD²^*

¹Cancer Research Program, Harrington Regional Medical Center, Amarillo, TX
²Blood and Marrow Transplant Program, Amarillo, TX

11:15 AM

380

Pharmacological Inhibition of NF-KB Underpins the Strong Synergy Between LC-1 and Fludarabine in Chronic Lymphocytic Leukaemia Cells

Saman Hewamana¹^*, Thet Thet Lin¹^*, Chris Fegan²^*, Steven Knapper¹, Alan Burnett¹^*, Paul Brennan³^*, Clare Rowntree²^* and Chris Pepper¹^*

¹Department of Haematology, School of Medicine, Cardiff University, Cardiff, United Kingdom
²Department of Haematology, University Hospital of Wales, Cardiff, United Kingdom
³Department of Medical Biochemistry & Immunology, School of Medicine, Cardiff University, Cardiff, United Kingdom

11:30 AM

381

17-DMAG Targets the NF-κB Family of Proteins to Induce Apoptosis in CLL: Clinical Implications of Hsp90 Inhibition

Amy J Wagner^*, Erin K Hertlein, PhD, Chelsey A Raymond^*, Derek A West^*, Joseph M Flynn, DO, MPH^*, Thomas Lin, MD, PhD, Amy J Johnson, PhD and John C Byrd, MD

The Ohio State University, Columbus, OH

11:45 AM

382

DNA-Dependent Protein Kinase Is a Therapeutic Target in Poor Prognosis B-Cell Chronic Lymphocytic Leukemia

Elaine Willmore, BSc, PhD¹, Sarah L. Elliott¹^*, Clark J. Crawford¹^*, Geoffrey Summerfield²^*, Tryfonia Mainou-Fowler³^*, Graham Jackson⁴^*, Paul Evans⁵^*, Paula Newton⁶^*, Duncan Gowans⁶^* and Barbara W. Durkacz¹^*

¹Northern Institute for Cancer Research, Newcastle Upon Tyne, United Kingdom
²Queen Elizabeth Hospital, Gateshead, United Kingdom
³Haematology, Newcastle University, Newcastle upon Tyne, United Kingdom
⁴Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
⁵St James University Hospital, Leeds, United Kingdom
⁶Sunderland Royal Hospital, Sunderland

12:00 PM

383

Disruption of Leukemia Stem Cell (LSC) Interactions with Bone Marrow Stromal Niche Enhances Efficacy of FLT3 Tyrosine Kinase Inhibitors (TKI) in Vivo

Patrick Brown, MD, Emily McIntyre^*, Li Li, PhD^* and Donald Small, MD, PhD^*

Oncology and Pediatrics, Johns Hopkins University, Baltimore, MD

12:15 PM

384

Adenosine A2A and Beta-2 Adrenergic Receptor Agonism: Novel Selective and Synergistic Multiple Myeloma Targets Discovered through Systematic Combination Screening

Richard J. Rickles, Ph.D.¹^*, Laura Pierce¹^*, Thomas Giordano¹^*, Winnie F. Tam, Ph.D.¹^*, William Avery²^*, Melissa Farwell²^*, David Crowe²^*, Mei Chen, Ph.D.¹^*, Alexander Brown¹^*, Vikram Kansra, PhD²^*, Steffan T. Nawrocki, PhD³^*, Jennifer S Carew, Ph.D.³, Francis J Giles, MD³ and Margaret S Lee, PhD¹^*

¹CombinatoRx, Incorporated, Cambridge, MA
²CombinatoRx, Inc., Cambridge, MA
³The Institute for Drug Development, CTRC, The University of Texas Health Science Center, San Antonio, TX

See more of: Oral and Poster Abstracts

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^*signifies non-member of ASH

604.O2.6 Mechanism of Drug Action And New Targets