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603.O2.8 Tumor Suppressors and Oncogenes II

Monday, December 8, 2008: 3:30 PM-5:30 PM
3002-3004 - West (Moscone Center)
Moderators:
Christian Buske, MD and Jason E. Levine
3:30 PM
MN1 Overexpression Promotes Proliferation and Self-Renewal of Primitive Normal Human Hematopoietic Cells

Suzan Imren, MD*, Michael Heuser, MD*, Ling-Yi Chen*, Glen Edin*, Connie J. Eaves, PhD* and R. Keith Humphries, MD, PhD

Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada

3:45 PM
Retroviral and Chemical Mutagenesis Identifies Pax5 as a Tumor Suppressor in B-Progenitor Acute Lymphoblastic Leukemia

Jinjun Dang, PhD1*, Charles G Mullighan, MBBS(Hons), MSc, MD1, Letha A. Phillips, BS1*, Perdeep Mehta, PhD2* and James R. Downing, MD1*

1Pathology, St. Jude Children's Research Hospital, Memphis, TN
2Hartwell Center, St Jude Children's Research Hospital, Memphis, TN

4:00 PM
MicroRNA-29a Is An Oncogene in Acute Myeloid Leukemia

Christopher Y. Park, MD, PhD1, Yoon-Chi Han, Ph.D.2*, Govind Bhagat, M.D.3*, Jian-Bing Fan, Ph.D.4*, Irving L Weissman, M.D.1* and Hua Gu, Ph.D.2*

1Institute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Palo Alto, CA
2Microbiology, Columbia University College of Physicians and Surgeons, New York, NY
3Pathology, Columbia University College of Physicians and Surgeons, New York, NY
4Illumina, Inc., San Diego, CA

4:15 PM
The Mir-17-19b Microrna Cluster Quantitatively Regulates the Self-Renewing Leukemia Stem Cell Compartment in MLL Leukemia

Piu Wong1*, Masayuki Iwasaki2*, Chang-Zheng Chen, PhD3 and Michael Cleary, MD4

1Whitehead Insitute for Biomedical research, Cambridge, MA
2Stanford University, Stanford
3Baxter Lab. of Genetic Pharmacology, Stanford Univ. School of Med., Stanford, CA
4Stanford University Med. Ctr., Stanford, CA

4:30 PM
AF4-MLL Expression Is Necessary and Sufficient for Leukemia Onset in Mice

Adelheid Bursen, PhD1*, Karen Schwabe1*, Brigitte Rüster, PhD2*, Anne Wenger, PhD3*, Martin Ruthardt, MD4*, Reinhard Henschler, MD2, Theo Dingermann, PhD1* and Rolf Marschalek, PhD1*

1Institute of Pharmaceutical Biology / DCAL / ZAFES, Goethe-University of Frankfurt, Frankfurt/Main, Germany
2Institute for Transfusion Medicine and Immunohaematology, Blood Transfusion Centre of the German Red Cross, Frankfurt/Main, Germany
3Centre d'Immunologie de Marsaille-Luminy, Marsaille, France
4Department of Internal Medicine II, Haematology, Goethe-University of Frankfurt, Frankfurt/Main, Germany

4:45 PM
Comprehensive Genomic Screens Reveal Multiple Modes of Action of the PLZF-RAR-α Oncoprotein

Kim L. Rice, Ph.D.1*, Itsaso Hormaeche, Ph.D.1*, Melanie J. McConnell, Ph.D.2, Sergei Doulatov, B.S.3*, Jared Flatow, M.S.1*, David Grimwade4, Ken I Mills, Ph.D., FRCPath5, John E. Dick, PhD6 and Jonathan D. Licht, MD1

1Hematology/Oncology, Northwestern University, Chicago, IL
2Cancer Cell and Molecular Biology, Malaghan Institute of Medical Research, Wellington South, New Zealand
3Dept of Molecular and Medical Genetics, Toronto General Research Institute, Toronto, ON, Canada
4Dept of Medical & Molecular Genetics, King's College London School of Medicine, London, United Kingdom
5Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, United Kingdom
6University Health Network, Toronto, ON, Canada

5:00 PM
Identification of the Involvement of the Tyrosine Kinase C-Ros in the Pathogenesis of Chronic Myelomonocytic Leukemia (CMML)

Daniela Cilloni, MD, PhD1, Sonia Carturan, PhD2*, Enrico Bracco, PhD3*, Ilaria Defilippi, PhD2*, Chiara Maffč, PhD4*, Ilaria Iacobucci5*, Marisa Pautasso, MD3*, Antonia Rotolo6*, Emilia Giugliano, PhD3*, Emanuela Messa, MD6*, Giovanni Martinelli, MD7* and Giuseppe Saglio, MD3

1dept of Clinical and Biological Sciences, University of Turin, Turin, Italy
2Department of Clinical and Biological Sciences, University of Turin, Orbassano,Turin, Italy
3Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
4Dept. Of Clinical and Biological Sciences, University of Turin, Turin, Italy
5Department of Hematology and Oncological Sciences "L. e A. Serągnoli", University of Bologna, Bologna, Italy
6Department of Clinical and Biological Sciences, University of Turin, Orbassano, Turin, Italy
7Department of Hematology and Oncological Sciences, University of Bologna, Bologna, Italy

5:15 PM
A Murine Model for the Transient Myeloproliferative Disorder of Down Syndrome: Phenotypic Influence of p53 on Reversible Megakaryoblastic Disorder

Kamaleldin E Elagib*, Lorrie L Delehanty* and Adam Goldfarb

Department of Pathology, University of Virginia, Charlottesville, VA

*signifies non-member of ASH