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603.O1.8 Tumor Suppressors and Oncogenes I

Monday, December 8, 2008: 7:00 AM-9:00 AM
3002-3004 - West (Moscone Center)
Moderators:
Aniruddha J Deshpande, PhD and Mark D. Minden, MD, PhD
7:00 AM
Pax5 Haploinsufficiency Cooperates with BCR-ABL1 to Induce Acute Lymphoblastic Leukemia

Christopher B Miller, BS1*, Charles G Mullighan, MBBS(Hons), MSc, MD1, Xiaoping Su, PhD1*, Jing Ma, PhD2*, Michael Wang, PhD2*, Jinghui Zhang, Ph.D.3*, Richard T Williams, MD, PhD4 and James R. Downing, MD1*

1Pathology, St. Jude Children's Research Hospital, Memphis, TN
2Hartwell Center, St. Jude Children's Research Hospital, Memphis, TN
3National Cancer Institute, Rockville, MD
4Oncology, St. Jude Children's Research Hospital, Memphis, TN

7:15 AM
Aberrant Splicing of the SLP65 SH2 Domain Enables Pre-B Cell Transformation and Compromises the Leukemia-Suppressive Function of the Pre-B Cell Receptor

Cihangir Duy1*, Lars Klemm1*, Rahul Nahar1*, Peter van Essen1*, Mieke Sprangers2*, Yong-mi Kim1*, Eugene Park1*, Giovanni Martinelli3*, Nora Heisterkamp1*, Wolf-Karsten Hofmann, MD4*, Hassan Jumaa5* and Markus Muschen2

1Childrens Hospital Los Angeles, University of Southern California, Leukemia Research Program, Los Angeles, CA
2Leukemia Research Program, Childrens Hospital Los Angeles, Los Angeles, CA
3Department of Hematology/Oncology “L. and A. Serągnoli”, University of Bologna, Italy
4MILE Study Group, on Behalf of European LeukemiaNet (ELN, WP13), Munich, Germany
5Molecular Immunology, Max-Planck-Institute for Immunology, Freiburg, Germany

7:30 AM
BCL6-Mediated Survival Signaling Promotes Drug-Resistance in BCR-ABL1-Driven Acute Lymphoblastic Leukemia

Cihangir Duy1*, J. Jessica Yu2*, Leandro Cerchietti3*, Lars Klemm1*, Rahul Nahar1*, Yong-mi Kim1*, Nora Heisterkamp1*, Giovanni Martinelli4*, Wolf-Karsten Hofmann, MD5*, Hassan Jumaa6*, Ari Melnick3, B. Hilda Ye, PhD7* and Markus Muschen8

1Childrens Hospital Los Angeles, University of Southern California, Leukemia Research Program, Los Angeles, CA
2Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY
3Hematology and Oncology Division, Weill Cornell Medical College, New York, NY
4Department of Hematology/Oncology “L. and A. Serągnoli”, University of Bologna, Italy
5MILE Study Group, on Behalf of European LeukemiaNet (ELN, WP13), Munich, Germany
6Molecular Immunology, Max-Planck-Institute for Immunology, Freiburg, Germany
7Dept. of Cell Biology, Albert Einstein College of Medicine, Bronx, NY
8Leukemia Research Program, Childrens Hospital Los Angeles, Los Angeles, CA

7:45 AM
Direct Transcriptional Repression of BCL2 by BCL6 in Germinal Centre B Cells and Its Disruption in B Cell Lymphomas with BCL2 Locus Alterations

Erich Piovan, MD, PhD*, Masumichi Saito, PhD*, Katia Basso, PhD*, Urban Novak, MD*, Qiong Shen*, Laura Pasqualucci, MD* and Riccardo Dalla-Favera

Institute for Cancer Genetics, Department of Pathology and Genetics & Development, Columbia University, New York, NY

8:00 AM
Growth Factor Independence 1 (Gfi1) Is An Essential Factor for the Development of Lymphoma

Cyrus Khandanpour, MD1, Ehssan Sharif-Askari, PhD1*, Paul Jolicoeur, MD, PhD2*, Ulrich Duehrsen, MD3* and Tarik Moroy, PhD1

1Institut de recherches cliniques de Montreal - IRCM, Montreal, QC, Canada
2Molecular Biology, Instit. de recherches cliniques de Montreal, Montreal, QC, Canada
3University Hospital Essen, Essen, Germany

8:15 AM
Inhibition of NOTCH1 Signaling and Glucocorticoid Therapy in T-ALL

Pedro Jose Real, PhD1*, Valeria Tosello, PhD1*, Teresa Palomero, PhD2, Mireia Castillo, MD3*, Catherine Sawai4*, Maria Luisa Sulis, MD5*, Jules P.P. Meijerink6*, Giuseppe Basso, MD7*, Iannis Aifantis, PhD, MSC8, Carlos Cordon-Cardo, MD9* and Adolfo A. Ferrando, MD, PhD1

1Institute for Cancer Genetics, Columbia University, New York, NY
2Institute for Cancer Genetics, New York, NY
3Pathology Department, Columbia University, New York
4Pathology Department, NYU Cancer Institute, New York, NY
5Pediatric Oncology, Columbia University, New York, NY
6Dept. of Pediatric Oncology/Hematology, ErasmusMC Rotterdam-Sophia Children's Hospital, Rotterdam, Netherlands
7Dept. Pediatrics, University of Padova, Padova, Italy
8Pathology, NYU School of Medicine, New York, NY
9Pathology Department, Columbia University, New York, NY

8:30 AM
The NF-κB Negative Regulator TNFAIP3 (A20) is Commonly Inactivated by Somatic Mutations and Genomic Deletions in Marginal Zone B-Cell Lymphomas

Urban Novak1*, Andrea Rinaldi2*, Ivo Kwee2*, Subhadra V. Nandula1*, Paola M.V. Rancoita3*, Mara Compagno1*, Michaela Cerri4*, Davide Rossi4*, Vundavalli V. Murty1*, Emanuele Zucca2*, Gianluca Gaidano4*, Riccardo Dalla-Favera1, Laura Pasqualucci1*, Francesco Bertoni2 and Govind Bhagat1

1Institute for Cancer Genetics, Department of Pathology and Genetics & Development, Columbia University, New York, NY
2Oncology Institute of Southern Switzerland, Laboratory of Experimental Oncology and Lymphoma Unit, Bellinzona, Switzerland
3Istituto Dalle Molle di Studi sull'Intelligenza Artificiale, Manno, Switzerland
4Division of Hematology, Department of Clinical and Experimental Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy

8:45 AM
Structural Analysis of a BAX-BIM SAHB Complex Reveals a Novel BH3 Interaction Site on BAX for Therapeutic Activation of Apoptosis

Evripidis Gavathiotis, Ph.D.1*, Motoshi Suzuki, Ph.D.2*, Marguerite L. Davis1*, Kenneth Pitter1*, Gregory H. Bird, PhD1*, Samuel G. Katz, MD, PhD1*, Ho-Chou Tu3*, Hyungjin Kim3*, Emily Cheng, M.D., Ph.D.3*, Nico Tjandra, Ph.D.2* and Loren D. Walensky, MD, PhD1

1Pediatric Oncology, Dana-Farber Cancer Institute, Children's Hospital Boston, Harvard Medical School, Boston, MA
2Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, Bethesda, MD
3Division of Molecular Oncology, Washington University in St. Louis School of Medicine, Saint Louis, MO

*signifies non-member of ASH