50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Disordered Gene Expression in Hematologic Malignancy, Including Epigenetic Regulation Poster I

Saturday, December 6, 2008: 5:30 PM-7:30 PM

Hall A (Moscone Center)

DNA Methylation in Resistant Paediatric Acute Lymphoblastic Leukaemia

Georgia Kapatai, PhD¹^*, Stephen O Nyangoma, PhD¹^*, Hannah M Martin, PhD²^* and Pamela R Kearns, MD, PhD¹^*

¹School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom
²Department of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom

1186

Differential Gene Expression Profile Identifies the Nature of T Cell Defects in AML Patients at Diagnosis

Rifca Le Dieu, MBBS¹^*, Alan G Ramsay, PhD¹, David Taussig, PhD¹^*, Richard Mitter²^* and John G. Gribben, MD, DSc¹

¹Medical Oncology, Barts and the London School of Medicine, London, United Kingdom
²Bioinformatics and Biostatistics, Cancer Research UK, London, United Kingdom

1187

Cdx4 Differs from Cdx2 in Its Oncogenic Potential and Its Regulation of Hox Gene Expression in the Murine Bone Marrow Transplantation Model

Silvia Thoene, MSc¹^*, Vijay P.S. Rawat, PhD¹^*, Vegi M. Naidu, MSc¹^*, Wolfgang Hiddemann, MD², Michaela Feuring-Buske, MD³^* and Christian Buske, MD⁴

¹CCG Leukemia, Helmholtz Zentrum Muenchen, Munich, Germany
²Department of Internal Medicine III, University of Munich-Hopsital Großhadern, Munich, Germany
³Department of Medicine III, Klinikum Grosshadern, LMU, Munich, Germany
⁴Helmholtz Centre, Munich, Munich, Germany

1188

PU.1 Epigenetically Represses the Expression of Metallothionein-1 Gene in Leukemia Cells

Shinichiro Takahashi, M.D., Ph.D.¹, Mami Okada¹^*, Akemi Imoto¹^*, Masako Nakahara, Ph.D.¹^*, Toshio Okazaki, Ph.D.¹^* and Hideo Harigae, M.D, Ph.D.²

¹Molecular Hematology, Kitasato University Graduate School of Medical Sciences, Sagamihara, Japan
²Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan

1189

Altered mRNA Expression of Pax-5 Is a Common Event in Acute Lymphoblastic Leukemia

Alessandra Santoro¹^*, Lea Dagnino¹^*, Cecilia Agueli¹^*, Domenico Salemi¹^*, Maria Grazia Bica¹^*, Annalisa Marfia¹^*, Sonia Cannella²^*, Marinella Veltroni³^*, Valentina Cetica³^*, Emanuela Giarin⁴^*, Francesco Fabbiano, MD¹^*, Giuseppe Basso, MD⁵^* and Maurizio Arico, MD³

¹Hematology I, Ospedale V. Cervello, Palermo, Italy
²Pediatric Hematology Oncology, Ospedale dei Bambini G. Di Cristina, Palermo
³Pediatric Hematology/Oncology, Azienda Ospedaliero-Universitaria Meyer, Florence, Italy
⁴Pediatrics, University of Padua, Padova, Italy
⁵Department of Pediatrics, Laboratory of Pediatric Oncohematology, University of Padova, Padova, Italy

1190

Major Mitochondrial DNA Deletions in Transgenic Mice Overexpressing a Human 8-Oxoguanine DNA-Glycosylase Leading to High Frequency of Lymphoma and Myeloproliferative Disorder

Qin Huang, MD, PhD¹, Haihong Zhang, M.D.²^*, Wei Chen, M.D.¹^*, Lawrence M. Weiss, M.D.¹^* and Chun-yang Fan, M.D., Ph.D²^*

¹City of Hope National Med. Ctr., Duarte, CA
²University of Arkansas for Medical Sciences, Little Rock, AR

1191

Induction of Hyperproliferative Fetal Megakaryopoiesis by An N-Terminally Truncated GATA1 Mutant

Ritsuko Shimizu¹^*, Eri Kobayashi²^*, James Engel, PhD³ and Masayuki Yamamoto²

¹Graduate School of Comprehensive Human Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Japan
²Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan
³University of Michigan, Ann Arbor, MI

1192

Pbx-1 Is a Direct Target of Evi-1 in Hematopoietic Stem/Progenitors and Leukemic Cells

Munetake Shimabe^*, Susumu Goyama, MD, PhD^*, Motoshi Ichikawa, MD, PhD^*, Yoichi Imai, MD, PhD^*, Tsuyoshi Takahashi, MD, PhD^*, Akira Hangaishi, MD, PhD^* and Mineo Kurokawa, MD, PhD

Hematology and Oncology, Graduate School of Med., Tokyo, Japan

1193

Distinct Expression Patterns in Cytogenetically Normal Acute Myeloid Leukemia (CN-AML) Characterized by Uniparental Disomy

Lars Bullinger¹, Jan Kronke²^*, Ursula Botzenhardt¹^*, Sabrina Heinrich¹^*, Katja Urlbauer¹^*, Simone Miller¹^*, Christian Schon¹^*, Richard F. Schlenk¹^*, Karlheinz Holzmann¹^*, Konstanze Dohner¹^* and Hartmut Dohner¹^*

¹Internal Medicine III, University of Ulm, Ulm, Germany
²University of Ulm, Ulm, Germany

1194

NK-Like Homeodomain Proteins Regulate NOTCH3-Signaling in T-Cells

Stefan Nagel, PhD¹^*, Letizia Venturini²^*, Grzegorz K. Przybylski³^*, Piotr Grabarczyk³^*, Corinna Meyer¹^*, Maren Kaufmann¹^*, Karin Battmer²^*, Christian A. Schmidt³^*, Hans G. Drexler¹^*, Michaela Scherr²^* and Roderick A.F. MacLeod¹^*

¹Human and Animal Cell Lines, DSMZ, Braunschweig, Germany
²Dept. of Hematology, Hemostaseology, Oncology and Stem Cell Transplantation, Medical School Hannover, Hannover
³Dept. of Internal Medicine C, University of Greifswald, Greifswald, Germany

1195

Acute Lymphoblastic Leukemia Cells Adapt to Post-Transplant Alloreactivity by Upregulating Sca-1

Jessica C Shand, MD¹^*, Andrew Campbell, BS²^*, Johan Jansson²^* and Craig A. Mullen, MD, PhD²

¹Department of Pediatrics, University of Rochester, Rochester, NY
²Division of Pediatric Hematology-Oncology, University of Rochester, Rochester, NY

1196

Ap-1 Family Members C-Jun, JunB and Fra-2 Mediate Apoptosis and Differentiation in AML through Activation of GADD45α and ADFP Following Non-Steroidal Anti-Inflammatory Drug Treatment

Akos Czibere, MD, PhD¹, Raminder Singh, PhD¹^*, Ingmar Bruns, MD, PhD², Luiz Fernando Zerbini, PhD³^* and Rainer Haas¹^*

¹Hematology, Oncology, Heinrich Heine University, Duesseldorf, Germany
²Hem./Onc. & Clin. Immuno., University of Dusseldorf, Dusseldorf, Germany
³BIDMC Genomics Center, Beth Israel Deaconess Medical Center, Boston, MA

1197

AML with Translocation T(8;16) Shows Unique Cytomorphological, Cytogenetic, Molecular, and Prognostic Features and Therefore Qualifies as An Own Entity According to WHO Criteria

Alexander Kohlmann, PhD¹, Martin Dugas, MD²^*, Hans-Ulrich Klein²^*, Christian Ruckert²^*, Wolfgang Kern, MD¹, Susanne Schnittger, PhD¹, Helmut Löffler, MD¹^*, Claudia Haferlach, MD¹ and Torsten Haferlach, MD¹

¹MLL Munich Leukemia Laboratory, Munich, Germany
²Department of Medical Informatics and Biomathematics, University of Münster, Münster, Germany

1198

Multiple Secondary Genetic Events Inducing Histologic Progression (HP) of Non-MALT Marginal Zone Lymphoma (MZL): An Integrated Genomic Analysis of Genome-Wide Copy-Number-Changes (CNC) and Transcriptomic Data

Lise Willems¹^*, Josette Briere²^*, Mahatsangy Raharijaona³^*, Benoit Ballester³^*, Samuel Quentin⁴^*, Roxane Legaie³^*, Delphine Rolland⁵^*, Thierry Jo Molina⁶^*, Pauline Brice⁷, Eric De Kerviler⁸^*, Christian Gisselbrecht¹^*, Francoise Berger⁹^*, Alexandra Traverse-glehen¹⁰^*, Lucile Baseggio¹¹^*, Pascale Felman¹¹^*, Gilles Salles¹², Bertrand Coiffier¹³, Jean Soulier, MD, PhD⁴, Remi Houlgatte¹⁴^* and Catherine Thieblemont¹⁵

¹Hemato-oncologie, Hôpital Saint-Louis (SLS) APHP, INSERM U 728 - Institut Universitaire d'Hématologie, Paris, France
²Service d'onco-hématologie, Hôpital Saint-Louis APHP, INSERM U728 - Institut Universitaire d'Hématologie, Paris, France
³Inserm U915, Institut du thorax, Faculté de Médecine, Université de Nantes, Nantes, France
⁴Hematology Laboratory, Hopital Saint-Louis, Paris, France
⁵INSERM U836 Equipe 7 - Faculte de Medecine, Universite J. Fourier, Grenoble, France
⁶Pathology, Université Paris Descarte and Hôtel Dieu Hospital, Paris, France
⁷Hopital Saint Louis
⁸Service de radiologie, Hopital Saint-Louis APHP, Paris, France
⁹Anatomie pathologique, Hospices Civils de Lyon, Centre hospitalier Lyon Sud - Université Lyon 1,, Pierre-Bénite, France
¹⁰Anatomie pathologique, Hospices Civils de Lyon, Centre hospitalier Lyon Sud - Université Lyon 1, Equipe d'Accueil 3737, Pierre-Bénite, France
¹¹Hematologie biologique, Hospices Civils de Lyon, Centre hospitalier Lyon Sud, Pierre-Benite, France
¹²Hematologie, Centre Hospitalier Lyon-Sud, Pierre-Benite, France
¹³Centre Hospitalier Lyon-Sud, Pierre-Benite
¹⁴INSERM U533 - Institut du thorax - Faculté de Médecine, Université de Nantes, Nantes, France
¹⁵Hemato-Oncology, Hopital Saint-Louis, APHP - INSERM U 728 - Institut Universitaire d'Hematologie, Paris, France

1199

Gene Expression Analysis of Bexarotene Differentiated Acute Myeloid Leukemias Identifies Known and Novel Gene Targets

Patricia Vanessa Sanchez, PhD¹^*, Reid P Bissonnette, PhD²^*, Donald E Tsai, MD, PhD³^* and Martin Carroll, MD¹

¹University of Pennsylvania, Philadelphia, PA
²Ligand Pharmaceuticals, San Diego, CA
³Hematology and Oncology, University of Pennsylvania, Philadelphia, PA

1200

Age Is the Strongest Determinant of Leukemia Blast Cell Gene Expression in MLL-Rearranged Infant ALL and MLL-AF4 Directs a Distinct Gene Expression Profile Related to CNS Disease

Blaine W. Robinson, PhD¹, Kajia Cao, PhD²^*, Joanne M. Hilden, MD³, Patricia A. Dinndorf, MD⁴^*, Nyla A. Heerema, PhD⁵, Harland N. Sather⁶^*, Ron McGlennen⁷^*, Stephen P. Hunger, MD⁸, Gregory H. Reaman, MD⁹, Li-San Wang, PhD²^* and Carolyn A. Felix, MD¹⁰

¹Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA
²Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA
³Peyton Manning Children's Hospital at St. Vincent, Indianapolis, IN
⁴Food and Drug Administration, Silver Spring, MD
⁵Cytogenetics, Department of Pathology, The Ohio State University, Columbus, OH
⁶University of Southern California, Arcadia, CA
⁷University of Minnesota Medical Center, Minneapolis, MN
⁸University of Colorado Denver School of Medicine and The Children's Hospital, Aurora, CO
⁹Children's National Medical Center, Washington, DC
¹⁰Division of Oncology/Department of Pediatrics, The Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA

1201

Kinome Profiling in Acute Myeloid Leukemia as a New Approach for Target Discovery

Arja ter Elst¹^*, Maikel P Peppelenbosch²^*, Sander H Diks²^*, Rob Ruijtenbeek³^*, Piet J Boender³^*, Rik de Wijn³^*, Frank J.G. Scherpen¹^*, Willem A Kamps¹ and Evelina S De Bont⁴

¹Division of Pediatric Oncology/Hematology, Department of Pediatrics,, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen Groningen, Groningen, Netherlands
²Department of Cell Biology, University of Groningen, Groningen, Netherlands
³PamGene International B.V, 's Hertogenbosch, Netherlands
⁴Pediatric Oncology/Hematology,, University Medical Center Groningen,, Groningen, Netherlands

1202

Integrated Genomic Profiling Identifies Preferential Expression of the Insulin Receptor in CLL with Deletion 11q

Sami Malek, MD, Peter Ouillette^*, Kerby Shedden^* and Kamlai Saiya-Cork^*

Comprehensive Cancer Ctr., Univ. of Michigan, Ann Arbor, MI

1203

Gene Expression Profiling Differentiates Childhood Acute Lymphoblastic Leukemia in Down Syndrome Versus Non-Down Syndrome Patients

Karen R. Rabin, MD¹, Jinhua Wang, PhD²^*, Anna Tsimelzon, PhD³^*, Debra Morrison, PhD²^*, Amos S. Gaikwad, PhD⁴^*, Laura Hogan, MD², Cassia L. Rye⁴^*, Susan G. Hilsenbeck, PhD³^*, Meenakshi Devidas, PhD⁵^*, Nyla A. Heerema, PhD⁶, Andrew J. Carroll, PhD⁷, Giuseppe Basso, MD⁸^*, William L. Carroll, MD⁹, Andrea Pession, MD, PhD¹⁰ and Deepa Bhojwani, MD¹¹^*

¹Pediatric Hematology/Oncology, Baylor College of Medicine, Houston, TX
²Pediatric Hematology-Oncology, New York University Medical Center, New York, NY
³Baylor College of Medicine
⁴Baylor College of Medicine, Houston, TX
⁵Children's Oncology Group, Gainesville, FL
⁶Ohio State University, Columbus, OH
⁷Department of Genetics, University of Alabama at Birmingham, Birmingham, AL
⁸Dept. Pediatrics, University of Padova, Padova, Italy
⁹New York University Cancer Institute, New York, NY
¹⁰Oncologia-Ematologia Pediatrica, Santorsola-Malpicitci, Bologna, Italy
¹¹Oncology, St Jude Children's Research Hospital, Memphis, TN

1204

Expression Patterns of Hoxa4 and Meis1 Genes Are Regulated by Promoter Hypermethylation and When Combined Predict Survival in AML

Lykke Christina Grubach, MSc^*, Mike Zangenberg^*, Hans Beier Ommen, M.D.^*, Anni Aggerholm^* and Peter Hokland, M.D.

Department of Hematology, Aarhus University Hospital, Aarhus, Denmark

1205

PIN1 Blocks Granulocytic Differentiation Via C-Jun in Acute Myeloid Leukemia with CEBPA Mutations

John Anto Pulikkan¹^*, Viola Dengler¹^*, Abdul Peerzada¹^*, Stefan Bohlander, MD²^*, Daniel G. Tenen, MD³ and Gerhard Behre¹^*

¹Kim IV, Landeszentrum für Zell- und Gentherapie, Halle, Germany
²Medizinische Klinik III, Klinikum Grosshadern, Munich, Germany
³Harvard Inst. of Med., Boston, MA

1206

Expression and Functional Analysis of Autotaxin, a Relevant Motility and Survival Factor, in FLT3-ITD Positive Acute Myeloid Leukemia and Primary Hematopoietic Stem Cells

Claudia Ortlepp¹^*, Christine Steudel¹^*, Sina Koch¹^*, Angela Jacobi²^*, Satu Kyttaelae¹^*, Martin Ryser²^*, Sebastian Brenner², Martin Bornhaeuser¹^*, Gerhard Ehninger¹ and Christian Thiede¹^*

¹Medical Clinic I, University Hospital, Dresden, Germany
²Department of Pediatrics, University Hospital, Dresden, Germany

1207

Low-Dose, Occupational Exposure to the Leukemogen Benzene Induces Robust Changes in the Blood Transcriptome Associated with Altered Immune System Biology

Cliona McHale¹^*, Luoping Zhang¹^*, Qing Lan²^*, Quilan Li³^*, Alan Hubbard¹^*, Kristin Porter¹^*, Roel Vermeulen⁴^*, Min Shen²^*, Stephen Rappaport¹^*, Songnian Yin³^*, Martyn T. Smith¹ and Nathaniel Rothman²^*

¹School of Public Health, University of California at Berkeley, Berkeley, CA
²Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD
³Chinese Center for Disease Control and Prevention, Beijing, China
⁴Environmental Epidemiology, Institute of Risk Assessment Sciences, Utrecht, Netherlands

1208

Gene Expression Differences Between Fetal Liver-Derived and Adult Bone Marrow-Derived Murine Megakaryocyte Progenitors: Implications for DS-TMD

Karen Wieland, MD^* and Alan B. Cantor, MD, PhD

Children's Hospital Boston, Boston, MA

1209

Mir-34a as Part of the Chemotherapy Resistance Network in Chronic Lymphocytic Leukemia

Thorsten Zenz¹^*, Julia Mohr¹^*, Eric Eldering²^*, Arnon P Kater³^*, Andreas Bühler¹^*, Dirk Winkler¹^*, Dirk Kienle¹^*, Jan Dürig⁴^*, Daniel Mertens¹^*, Hartmut Döhner¹ and Stephan Stilgenbauer¹^*

¹Internal Medicine III, University of Ulm, Ulm, Germany
²Department of Hematology and Experimental Immunology, Academic Medical Center, Amsterdam, Netherlands
³Department of Hematology, Academic Medical Center and University of California San Diego, Amsterdam, Netherlands
⁴Department of Hematology, University Duisburg-Essen, Essen

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^*signifies non-member of ASH

602.P1.89 Disordered Gene Expression in Hematologic Malignancy, Including Epigenetic Regulation Poster I