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601.P1.24 Chromosomal Rearrangements Poster I

Sunday, December 7, 2008: 6:00 PM-8:00 PM
Hall A (Moscone Center)
New Insights to the MLL Recombinome Including 8 Novel Partner Genes ACTN4, C2CD3, DCP1A, FLNA, LAMC3, LOC100128568, NRIP3, and TNRC18

Claus Meyer, PhD1*, Eric Kowarz, PhD1*, Julia Hofmann1*, Thomas Fischer1*, Sara El Ashkar1*, Andrea Teigler-Schlegel, PhD2*, Brian Balgobind, MD3*, Thomas Burmeister, PhD4*, Etienne De Braekeleer5*, Eric Delabesse, PhD6*, Aline Renneville, MD7*, Theo Dingermann, PhD1*, Thomas Klingebiel, MD8 and Rolf Marschalek, PhD1*

1Diagnostic Center of Acute Leukemia (DCAL), Institute of Pharmaceutical Biology, Goethe-University of Frankfurt, Frankfurt/M, Germany
2Department of Pediatric Hematology and Oncology, Children's University Hospital, Giessen, Giessen, Germany
3Pediatric Hematology/Oncology, Erasmus MC, Sophia Children's Hospital, Rotterdam, Rotterdam, Netherlands
4Medizinische Klinik III, Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, Berlin, Germany
5Laboratoire d'Histologie, Embryologie et Cytogénétique, Faculté de Médecine et des Sciences de la Santé, Université de Bretagne Occidentale, Brest, France
6Laboratoire d'Hématologie, CHU Purpan, Toulouse, France
7Laboratoire d'Hématologie, Centre de Biologie-Pathologie, CHRU de Lille, Lille, France
8Pediatric Hematology and Oncology, Goethe-University of Frankfurt, Frankfurt/M, Germany

Recurrent Chromosomal Intermingling Interactions at the BCL2 Locus in T(14;18) +Ve and -Ve Cell Lines

Youwen Yang, Dr*, David J Wrench, Dr*, T. Andrew Lister and Jude Fitzgibbon, Dr*

Centre for Medical Oncology, Barts and the London School of Medicine and Dentistry, London, United Kingdom

Genetic Abnormalities Involved in the Development and Progression of Follicular Lymphoma

Karen E Deffenbacher, Ph.D.1*, George Wright, Ph.D.2*, Javeed Iqbal, Ph.D.3*, Huimin Geng, M.S.1*, Derville O'Shea, M.D.4*, T. Andrew Lister4, Jude Fitzgibbon4, Kai Fu, MD, PhD5, Zhongfeng Liu, M.D.1*, Dennis Weisenburger6*, Timothy C. Greiner, MS, MD7, Randy D. Gascoyne, MD8, Andreas Rosenwald9*, Elias Campo, MD, PhD10*, Lisa M. Rimsza9, Jan Delabie11*, Elaine S Jaffe, M.D.12*, Louis M. Staudt, MD., Ph.D.2 and Wing C. Chan3

1Pathology/Microbiology, University of Nebraska Medical Center, Omaha, NE
2Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Health Institutes, Bethesda, MD
3Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE
4Centre for Medical Oncology, Barts and the London School of Medicine and Dentistry, London, United Kingdom
5Dept. of Pathology & Microbiology, University of Nebraska Med. Ctr., Omaha, NE
6Univ. of Nebraska Medical Center, Omaha, NE
7Pathology & Microbiology, Univ. of NE Med. Ctr., Omaha, NE
8British Columbia Cancer Agency, Vancouver, BC, Canada
9LLMPP
10Pathology, Hospital Clínic, Barcelona, Spain
11Pathology, Norwegian Radium Hospital, Oslo, Norway
12Center for Cancer Research, National Cancer Institute, Bethesda, MD

B Cells with BCL2/IGH Translocation Compose a Distinctive Cell Population That May Serve as a Reservoir of Lymphoma of Germinal Center B-Cell Type

Tomomi Sakai1*, Momoko Nishikori1, Masaharu Tashima1*, Ryo Yamamoto1*, Toshio Kitawaki1*, Akifumi Takaori-Kondo1*, Shinobu Tsuzuki2 and Takashi Uchiyama1

1Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
2Dept. of Molecular Med., Aichi Cancer Ctr., Nagoya, Japan

Tissue Origin of Igh/Myc Chromosomal Translocations in An Accelerated Pristane-Induced Plasma Cell Tumor Model using  BALB/C-Bcl-Xl Transgenic Mice and the Inhibitory Effects of Defective Genes Governing Class Switch recombination  in Ung and Aicda Knockout Mice

Alexander L Kovalchuk1*, Rafael Casellas2*, Wendy duBois3*, Helena Tolarova2*, Petr F Hausner4*, Elizabeth Mushinski3*, Patrick J Nelson3*, Herbert Morse III1 and Michael Potter3*

1Laboratory of Immunopathology, National Institutes of Health, NIAID, Rockville, MD
2National Institutes of Health, Genomic Integrity and Immunity, NIAMS, Bethesda, MD
3Laboratory of Cancer Biology and Genetics, National Institutes of Health, NCI, Bethesda, MD
4Greenebaum Cancer Cente, University of Maryland, Baltimore, MD

Three Heritable T Cell Malignancy Models Established Using a Forward Genetic Mutagenesis Screen in Zebrafish

J. Kimble Frazer, MD, PhD1*, Nathan Meeker, MD2*, Diana F. Bradley1*, Lynnie Rudner3*, Sherrie L. Perkins, MD, PhD4 and Nikolaus Trede, MD, PhD1*

1Pediatrics and Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
2Hematology and Bone Marrow Transplant, University of Utah, Salt Lake City, UT
3Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
4Pathology, University of Utah and ARUP Institute, Salt Lake City, UT

Ultra-High Resolution Analysis of Genomic Alterations in High-Risk Acute Lymphoblastic Leukemia

Charles G Mullighan, MBBS(Hons), MSc, MD1, Letha A. Phillips, BS1*, Lesli A. Kiedrowski1*, Jing Ma, PhD2*, Richard T. Williams, MD, PhD3, Sheila A. Shurtleff1*, Charles J. Sherr, MD, PhD4 and James R. Downing, MD1*

1Pathology, St. Jude Children's Research Hospital, Memphis, TN
2Hartwell Center, St. Jude Children's Research Hospital, Memphis, TN
3Oncology, St. Jude Children's Research Hospital, Memphis, TN
4Howard Hughes Medical Institute and Department of Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN

Sequential Order of Genetic Events in NUP214-ABL1 Positive T-Cell Leukemia

Markus Pisecker1*, Lisa Arzt1*, Margit König1*, Reinhard Ullmann2* and Sabine Strehl1*

1CCRI, Children's Cancer Research Institute, Vienna, Austria
2Max Planck Institute for Molecular Genetics, Berlin, Germany

Unbalanced Chromosome Rearrangements Involving the 20q11.2 Region in Myeloid Malignancy

Julie Howard-Reeves, BSc1*, Mikel Valgañón, PhD1*, Helen Mazzullo, BSc1*, Colin Grace, PhD1*, Lynda Campbell, MBBS, FRCPA2* and Elisabeth Nacheva, MD, PhD, FRCPath3

1Academic Haematology, Room 1-434, Royal Free and UCL Med School, London, United Kingdom
2Cytogenetics, St Vincent's Hospital, Melbourne, Australia
3Academic Hematology, Royal Free & Univ. College London, London, ARRAY(0xc565528)

Definition of Commonly Deleted Regions and Identification of Candidate Genes of Chromosome 20 in Myeloid Malignancies Using Genome-Wide Single Nucleotide Polymorphism (SNP) Array

Jungwon Huh, MD1*, Ramon V. Tiu, MD, BS1, Ying Jiang, MD, PhD1*, Lukasz P Gondek, MD, PhD1*, Christine O'Keefe, PhD1*, Karl S. Theil, MD2 and Jaroslaw P Maciejewski, MD, PhD1

1Hematologic Oncology and Blood Disorders/Experimental Hematology and Hematopoiesis Section, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
2Department of Clinical Pathology, Cleveland Clinic, Cleveland, OH

Array-Based Karyotyping and Genotyping Demonstrates a Non Random Selection of Allelic Variants of Genes in Clones with 5q31 Deletion Mutants

Lukasz P Gondek, MD1*, Hemant Ishwaran, PhD2*, Andrew Jeffrey Dunbar, BS3*, Christine L. O'Keefe, PhD4, Michael A McDevitt, MD, PhD5, Denise Batista, PhD6*, Mikkael A. Sekeres, MD, MS7, Ghulam J Mufti, MD, PhD8 and Jaroslaw Maciejewski, MD, PhD9

1Experimental Hematology and Hematopoiesis Section/Internal Medicine, Cleveland Clinic, Cleveland, OH
2Department of Quantitative Sciences, Cleveland Clinic, Cleveland, OH
3Cleveland Clinic, Cleveland, OH
4Exp. Hem. & Hematopoiesis Sect., Cleveland Clinic, Cleveland, OH
5Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
6Department of Pathology, Johns Hopkins University, Baltimore, MD
7Hematologic Oncology and Blood Disorders R35, Cleveland Clinic, Cleveland, OH
8Department of Haematological Medicine, Kings College London, London, United Kingdom
9Experimental Hematology and Hematopoiesis Section, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH

High-Resolution Array-Based Comparative Genome Hybridization (CGH) Identifies Novel and Recurrent Regions in CLL

Vladimir Grubor, PhD1, Alex Krasnitz, PhD1*, Jennifer E. Troge1*, Jennifer L. Meth1*, B. Lakshmi, PhD1*, Jude T. Kendall1*, Boris Yamrom, PhD1*, Garrick Alex1*, Deepa Pai1*, Nicholas Navin1*, Lisa A. Hufnagel1*, Yoon-ha Lee, PhD1*, Kerry Cook1*, Steven L. Allen, MD2, Kanti R. Rai, MD3*, Rajendra Damle, PhD4, Carlo Calissano, PhD5*, Nicholas Chiorazzi, MD6*, Michael H Wigler, PhD1* and Diane Esposito, PhD1

1Cold Spring Harbor Lab., Cold Spring Harbor, NY
2Medicine, North Shore University Hospital - LIJ, Lake Success, NY
3North Shore Long Island Jewish Health Systems, New Hyde Park, NY
4North Shore - LIJ Research Inst., Manhasset, NY
5The Feinstein Institute for Medical Research, North Shore - LIJ Health System, Manhasset, NY
6Feinstein Institute for Medical Research, North Shore–LIJ Health System, New York, NY

*signifies non-member of ASH