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601.O1.8 Chromosomal Rearrangements and Cooperating Lesions in Lymphoid and Myeloid Malignancies

Tuesday, December 9, 2008: 7:00 AM-9:00 AM
2006-2008 - West (Moscone Center)
Moderators:
Matthew P. Strout, MD, PhD and Carolyn A. Felix, MD
7:00 AM
A Role for Small RNA Molecules during the DNA Repair Phase of Somatic Hypermutation

Matthew P. Strout, M.D., Ph.D.1 and David G. Schatz, Ph.D.2*

1Internal Medicine/Hematology and Immunobiology, Yale University School of Medicine, New Haven, CT
2Immunobiology, Yale University School of Medicine, New Haven, CT

7:15 AM
Micro-RNA Gene Deregulation by Chromosome Translocations with Fragile Genomic Regions in B-Cell Lymphoma Cells

Bjoern Schneider, PhD*, Stefan Nagel, PhD*, Maren Kaufmann*, Hans G. Drexler, MD and Roderick A.F. MacLeod, PhD*

Human and Animal Cell Lines, DSMZ, Braunschweig, Germany

7:30 AM
IGH@ Translocations Involving the Pseudoautosomal Region 1 (PAR1) of Both Sex Chromosomes Deregulate the Cytokine Receptor-Like Factor 2 (CRLF2) Gene in B Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL)

Lisa J Russell1*, Melania Capasso2*, Inga Vater3*, Anthony V Moorman1, Takashi Akasaka2*, Lana Harder3*, Olaf Heidenreich1*, Lee Machado2*, Stephan Gest3*, Jonathan C Strefford4*, Thiruppavai Chandrasekaran2*, Holger Tönnies3*, Aneela Majid2*, Olivier Bernard5*, Martin JS Dyer2*, Reiner Siebert3* and Christine J Harrison1*

1Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom
2MRC Toxicology Unit, University of Leicester, Leicester, United Kingdom
3University Hospital Schleswig-Holstein, Institute of Human Genetics, Kiel, Germany
4Cancer Sciences Division, University of Southampton, Southampton, United Kingdom
5Hôpital Necker-Enfants Malades, Laboratoire d'Hématologie, Paris, France

7:45 AM
Genetic Abnormalities Underlying B-Cell Development Are Characteristic for a New Subgroup of Childhood Precursor B-ALL with a Very Poor Prognosis

Marjon van Slegtenhorst, PhD1*, Renee X de Menezes, PhD2*, Rob Pieters, MD, PhD3 and M. L Den Boer, MSc, PhD4

1Pediatric Oncology, Rotterdam, Netherlands
2ErasmusMC and LUMC, Rotterdam, Netherlands
3Dept. of Pediatric Hem./Onc., Erasmus MC, Rotterdam, Netherlands
4Dept. of Pediatric Onc./Hem., Erasmus Medical Center, Rotterdam, Netherlands

8:00 AM
Focal Deletion of Genes Involved in the Control of Cell Cycle Progression Contributes to Growth Factor Independence in Acute Lymphoblastic Leukemia Cells

Bart Nijmeijer, PhD1, Karoly Szuhai, MD, PhD2*, Henriette M Goselink1*, Marianke LJ Van Schie1*, Danielle De Jong2*, Roelof Willemze, MD, PhD1 and J.H. Frederik Falkenburg, MD, PhD1

1Hematology, Leiden University Medical Center, Leiden, Netherlands
2Molecular Cell Biology, Leiden University Medical Center, Leiden, Netherlands

8:15 AM
Variable Breakpoints Target PAX5 in Patients with Dicentric Chromosomes: A Model for the Basis of Unbalanced Translocations in Cancer

Jonathan C Strefford, PhD1*, Qian An, PhD1*, Sarah L Wright, BSc1*, Zoe J Konn, BSc1*, Elizabeth Matherson, PhD2*, Lynne Minto, PhD2*, Anthony V Moorman, PhD2, Helen Parker, PhD1*, Andrew Hall, PhD2, Julie Irving, PhD2 and Christine J Harrison, PhD2*

1Cancer Sciences Division, University of Southampton, Southampton, United Kingdom
2Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, United Kingdom

8:30 AM
Molecular Characterization of the t(15;17)(q22;21) in Epirubicin-Related Acute Promyelocytic Leukaemia

Ashley Nicole Mays1*, Neil Osheroff2*, Carolyn Felix3*, Jo Ann Byl2*, Kandeepan Saravanamuttu4*, Andrew Peniket5*, Robert Corser6*, Cherry Chang7*, Christine Hoyle8, Anne N Parker9*, Syed K Hasan10*, Francesco Lo-Coco10*, Ellen Solomon1* and David Grimwade1

1Dept of Medical & Molecular Genetics, King's College London School of Medicine, London, United Kingdom
2Vanderbilt University, Nashville, TN
3Children's Hospital of Philadelphia & University of Pennsylvania, Philadelphia, PA
4Lincoln County Hospital, Lincoln, United Kingdom
5John Radcliffe Hospital, Oxford, United Kingdom
6Queen Alexandra Hospital, Portsmouth, United Kingdom
7Derby Royal Infirmary, Derby, United Kingdom
8Glan Clwyd Hospital, Rhyl, United Kingdom
9Beatson, West of Scotland Cancer Centre, Glasgow, United Kingdom
10University of Tor Vergata, Rome, Italy

8:45 AM
Myc Drives Chromosomal Gain in Acute Myeloid Leukemia

Letetia Jones1*, Sabina Sevcikova1*, Vernon Phan1*, Sachi Jain1*, Angell Shieh2*, Joshua Dubansky1*, Min Li1*, Mei Lin Maunakea1*, George Zhu1*, Thelma R Tennant3*, Scott Lowe4*, Michelle M. Le Beau3 and Scott C. Kogan1

1Department of Laboratory Medicine, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA
2Department of Pediatrics, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA
3Section of Hematology/Oncology, Cancer Research Center, Chicago, IL
4Howard Hughes Medical Institute, Cold Spring Harbor, NY

*signifies non-member of ASH