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508.O2.6 Bone Marrow Failure

Monday, December 8, 2008: 1:30 PM-3:00 PM
120-121-122-123-124-125 - North (Moscone Center)
Moderators:
Robert Brodsky and Pierre Villeneuve
1:30 PM
Iron Chelation in Regularly Transfused Patients with Aplastic Anemia: Efficacy and Safety Results from the Large Deferasirox EPIC TrialClinically Relevant Abstract

Jong Wook Lee1*, Sung-Soo Yoon2*, Zhi Xiang Shen3*, Hui-Chi Hsu4*, Arnold Ganser5, Dany Habr6*, Gabor Domokos7*, Abdel Hmissi7* and John B Porter8*

1The Catholic University of Korea, Seoul, South Korea
2Seoul National University College of Medicine, Seoul, South Korea
3Ruijin Hospital, Shanghai Second Medical University, Shanghai, China
4Taipei City Hospital, Taipei, Taiwan
5Medizinische Hochschule Hannover, Hannover, Germany
6Novartis, East Hanover, NJ
7Novartis, Basel, Switzerland
8University College London, London, United Kingdom

1:45 PM
Hematopoietic Stem Cell Defects in Novel Fanconi Anemia Mouse Models

Kalindi Parmar, PhD1, Jung Min Kim, PhD1*, Akiko Shimamura, MD, PhD2, Anna Stuckert1*, Mary K DeLoach1*, Kaya Zhu1*, Peter M. Mauch, MD1, Jeffery Kutok, MD, PhD3, Jon Aster, MD, PhD3, Koichi Akashi, MD, PhD4, D. Gary Gilliland, MD, PhD5 and Alan D. D'Andrea, MD1*

1Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
2Pediatric Hematology/Oncology, University of Washington, Seattle, WA
3Pathology, Brigham & Women's Hospital, Boston, MA
4Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
5Medicine, Howard Hughes Medical Institute, Brigham & Women's Hospital,Harvard Medical School, Boston, MA

2:00 PM
Fanconi Anemia and the Response of Human Hematopoietic Cells to DNA Damage

Magan Trottier* and Stephen Meyn*

Genetics and Genome Biology, Hospital for Sick Children, Toronto, ON, Canada

2:15 PM
Telomere Length of Peripheral Blood Leukocytes Predicts Relapse and Clonal Evolution after Immunosuppressive Therapy in Severe Aplastic AnemiaClinically Relevant Abstract

James N Cooper, B.A.1*, Rodrigo Calado, MD, PhD2, Colin Wu, PhD2*, Phillip Scheinberg, MD2 and Neal Young, MD2

1Clinical Research Training Program, National Institutes of Health, Bethesda, MD
2National Institutes of Health, National Heart, Lung, and Blood Institute, Bethesda, MD

2:30 PM
SNP Karyotyping Can Detect Clonality of Stem Cell Compartment and Early Malignant Evolution in Aplastic Anemia

Marcin Wlodarski*, Sanjay Mohan*, Lukasz Gondek*, Jungwon Huh*, Michael Clemente*, Ramon Tiu* and Jaroslaw Maciejewski

Experimental Hematology and Hematopoiesis Section, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH

2:45 PM
FANCD2 Participates in JAK2-Dependent Activation of STAT5a

Grover C. Bagby Jr., MD and Laura E Hays, PhD*

Oregon Health and Science University Cancer Institute, Portland, OR

*signifies non-member of ASH