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507.O1.6 Hematopoiesis - Malignant Stem and Progenitor Cells

Monday, December 8, 2008: 1:30 PM-3:00 PM
2001-2003-2014-2016 - West (Moscone Center)
Moderators:
Allison Blair, PhD, BSc and Tessa Holyoake
1:30 PM
Common Self-Renewal Pathways Contribute to the Induction of Acute Myeloid Leukemias Associated with Different OncogenesClinically Relevant Abstract

Brynn T Kvinlaug, BSc, MSc1*, Wai-In Chan, PhD1*, Lars Bullinger, MD2*, Christopher Sears3*, Donna Paul1*, Rachel Okabe, BSc4*, Benjamin H Lee, MD, PhD4*, Inusha De Silva, PhD1*, Scott Armstrong, MD, PhD3*, Hartmut Dohner, MD2*, D. Gary Gilliland5 and Brian JP Huntly, MD, PhD1*

1Hematology, University of Cambridge, Cambridge, United Kingdom
2Department of Internal Medicine III, University of Ulm, Ulm, Germany
3Hematology, Childrens Hospital, Boston, MA
4Harvard Medical School, Brigham & Women's Hospital, Boston, MA
5Brigham and Women's Hospital, Boston, MA

1:45 PM
Bi-Phenotypic Leukemic Cells as Transient Intermediates Between Leukemic Stem Cells with Lymphoid Characteristics and the Leukemic Myeloid Bulk: Insights from a Murine Model of CALM/AF10 Positive Acute Myeloid LeukemiaClinically Relevant Abstract

Aniruddha Deshpande1*, Hendrik Reuter2*, Medhanie Mulaw1*, Monica Cusan1*, Wolfgang Hiddemann1, Stefan Bohlander1*, Michaela Feuring-Buske1* and Christian Buske1

1Helmholtz Centre, Munich, Munich, Germany
2Division of Molecular Genetics, German Cancer Research Center, Heidelberg, Germany

2:00 PM
The Deletion of the Proline-Rich Region of HOXB4 Is Associated with Myeloid Leukemia in a Mouse Model

Monica Cusan1*, Aniruddha Deshpande1*, Vijay Rawat1*, Wolfgang Hiddemann1*, Leticia Quintanilla-Martinez, MD2*, R. Keith Humphries, MD, PhD3, Christian Buske, MD1 and Michaela Feuring-Buske1*

1Helmholtz Centre, Munich, Munich, Germany
2Pathology, University Hospital Tuebingen, Eberhard-Karls-University, Tuebingen, Germany
3Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada

2:15 PM
OTT-MAL Activates the Notch Signaling Transcription Factor RBPJ and Cooperates with Mutant MPL to Induce Acute Megakaryoblastic Leukemia

Thomas Mercher, Ph.D1*, Glen D. Raffel, MD, PhD2, Sandra A Moore3*, Melanie G Cornejo4*, Dominique Baudry-Bluteau, Ph.D5*, Nicolas Cagnard6*, Jonathan Jesneck7*, Yana Pikman3*, Dana E. Cullen8*, Ifor Williams9*, Koichi Akashi, MD, PhD10, Hirokazu Shigematsu10*, Jean-Pierre Bourquin, MD, PhD11*, Marco Giovannini, MD, PhD12*, William Vainchenker5, Ross L Levine, MD13, Benjamin H. Lee, MD, PhD14*, Olivier Bernard15* and D. Gary Gilliland14

1Brigham and Women's Hospital, 1 Blackfan circle 02115 Boston USA and INSERM EMI0210, Universite Paris V-Descartes, Paris, France
2Beth Israel Deaconess Med. Ctr., Boston, MA
3Department of Medicine, Brigham and Women's Hospital, Boston, MA
4Harvard Medical School, Boston, MA
5INSERM U790, Villejuif, France
6INSERM EMI0210, Paris, France
7Dana Farber Cancer Institute, Boston, MA
8Department of Medicine, Division of Hematology, Brigham and Women's Hospital; Dana-Farber Cancer Institute; Harvard Medical School, Boston, MA
9Hematology & Oncology, Emory University, Atlanta, GA
10Dana-Farber Cancer Inst., Boston, MA
11Paediatric Haematology/Oncology, University of Zurich, Zurich, Switzerland
12INSERM U434, Paris, France
13Memorial Sloan-Kettering Cancer Center, New York, NY
14Brigham and Women's Hospital, Boston, MA
15Hôpital Necker-Enfants Malades, Laboratoire d'Hématologie, Paris, France

2:30 PM
Oxidative Stress-Mediated Activation of AKT/mTOR Signaling Pathway Leads to Myeloproliferative Syndrome in FoxO3 Null Mice: A Role for Lnk Adaptor Protein

Safak Yalcin1*, Sathish Kumar Mungamuri1*, Dragan Marinkovic1*, Xin Zhang1*, Wei Tong, PhD2, Dana Cullen1* and Saghi Ghaffari, MD, PhD3

1Mount Sinai School of Medicine, New York, NY
2CHOP, Philadelphia, PA
3Department of Molecular, Cell & Developmental Biology, Department of Gene and Cell Medicine, New York, NY

2:45 PM
High Levels of MicroRNA-126 Bioactivity Specify the LSC Compartment in AML

Eric R Lechman, MS, PhD1*, Hidefumi Hiramatsu, MD, PhD2, Bernhard Gentner, MD3*, Kristin Hope, PhD1*, Katsuto Takenaka, MD4, Kolja Eppert, PhD1*, Mark D. Minden, MD, PhD5, Luigi Naldini6* and John E. Dick, PhD7

1Cell and Molecular Biology, University Health Network, Toronto, ON, Canada
2Toronto Med. Discovery Tower 8-301, Toronto, ON, Canada
3HSR-TIGET, Milan, Italy
4Dept. of Internal Medicine I, Kyushu Univ. Med. School, Fukuoka, Japan
5Princess Margaret Hospital, Toronto, ON, Canada
6Telethon Institute for Gene Therapy, San Raffaele Scientific Institute, Milan, Italy
7University Health Network, Toronto, ON, Canada

*signifies non-member of ASH