50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Hematopoiesis - Apoptosis and Cell Cycle Regulation Poster

Saturday, December 6, 2008: 5:30 PM-7:30 PM

Hall A (Moscone Center)

Cdk1-Dependent Phosphorylation ofNPM Overrides G₂/M Checkpoint and Increases Leukemic Blasts in Mice

Wei Du, M.D., PhD.¹, Yun Zhou, PhD²^*, Suzette Pike, MS¹^* and Qishen Pang, PhD¹

¹Experimental Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²Veterinary Integrative Biosciences, Huston, TX

1323

Identification and Characterization of Sur3γ and Sur3γV, Two Novel Splice Variants of Survivin in HSPC

Janardhan Sampath, Ph.D.¹^*, Lissa Smith, BSc²^* and Louis M. Pelus, PhD²

¹Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN
²Microbiology and Immunology and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN

1324

Genetic and Proteomic Analysis of Functionally Distinct Human Hematopoietic Stem Cells from Bone Marrow, Mobilized Peripheral Blood, and Cord Blood

Brahmananda Reddy Chitteti, Ph.D.¹^*, Bradley Poteat¹^*, Mu Wang, Ph.D.²^*, Yunlong Liu, Ph.D.³^* and Edward F. Srour, PhD⁴

¹Medicine, Indiana University, Indianapolis, IN
²Biochemistry and Molecular Biology, Indiana University, Indianapolis, IN
³Biostatistics, Indiana University, Indianapolis, IN
⁴IN Cancer Rsch. Inst., IN Univ. School of Med., Indianapolis, IN

1325

Polycomb Group Ring Finger 5 (PCGF5) Is a Notch Transcriptional Target and Regulates Cell Size and Cell Cycle in Hematopoietic Progenitors

Chris L Cochrane¹^*, Hind Medyouf, PhD¹ and Andrew P. Weng, MD, PhD²

¹Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada
²Terry Fox Laboratory/Dept of Pathology, BC Cancer Agency, Vancouver, BC, Canada

1326

Enforced Nr4a2 expression Drives HSCs into Quiescence

Olga Sirin, BS/MS¹^*, Orla M Conneely, PhD²^* and Margaret A. Goodell, PhD³

¹Molecular and Human Genetics, Baylor College of Medicine, Houston, TX
²Cell Biology, Baylor College of Medicine
³Stem Cells and Regenerative Medicine, Baylor College of Medicine, Houston, TX

1327

Differential Maintenance of Cell Cycle Status of Human Bone Marrow- and Umbilical Cord Blood-Derived CD34+ Cells after Homing to the Bone Marrow Microenvironment

Bradley A. Poteat¹^*, Brahmananda Reddy Chitteti¹^*, Karen E. Pollok¹^*, Attaya Suvannasankha¹^* and Edward F. Srour, PhD²

¹Medicine, Indiana University, Indianapolis, IN
²IN Cancer Rsch. Inst., IN Univ. School of Med., Indianapolis, IN

1328

Survivin Is Required for Proliferation, but Not Polyploidization of Megakaryocytes

Jeremy Q Wen, PhD, MD¹^*, Cindy Leung, PhD²^*, Zan Huang, PhD³^*, Sara Small⁴^* and John Crispino, PhD⁵

¹Hematology and Oncology, Northwestern University, Chicago, IL
²Northwestern University, Chicago, IL
³Dept Med/Div Hematol&Oncol, Northwestern University, Chicago, IL
⁴Medicine, Northwestern University, Chicago, IL
⁵Medicine, Hematology/Oncology, Northwestern University, Chicago, IL

1329

Role of Lipocalin 24p3 in Apoptosis and Leukemia

L.R. Devireddy, DVM, PhD

Dept. of Pathology, Case Western Reserve Univ., Cleveland, OH

1330

Erucylphosphohomocholine, the First Intravenously Applicable Alkylphosphocholine, Induces Cell Cycle Arrest, Apoptosis, and Synergizes with Chemotherapeutic Drugs in Acute Myelogenous Leukemia Cells-a Novel Therapeutic Approach for Leukemia

Veronica Papa, BS¹^*, PierLuigi Tazzari, MD²^*, Francesca Chiarini, BS¹^*, Francesca Ricci, BS²^*, Giovanni Martinelli, MD³, Andrea Bontadini, MD²^*, James McCubrey, PhD⁴, Lars H Lindner, MD⁵^*, Hansjoerg Eibl, PhD⁶^* and Alberto M. Martelli, MD¹

¹Dept. of Human Anatomical Sci., Univ. of Bologna, Bologna, Italy
²Transfusion Center, Policlinico S.Orsola-Malpighi, Bologna, Italy
³Hematology and Oncology, University of Bologna, Italy
⁴School of Medicine, East Carolina University, Greenville, NC
⁵Department of Internal Medicine III, University of Munich-Grosshadern Campus, Munich, Germany
⁶Max Planck Institute for Biophysical Chemistry, Goettingen, Germany

1331

Embryonic Stem Cells Bypass Numerous Cell Cycle Checkpoints; Not Just G1

Charlie Mantel¹ and Hal E. Broxmeyer, PhD²

¹IN Univ. School of Med., Indianapolis, IN
²Indiana University School of Medicine, Walther Oncology Center, Indianapolis, IN

1332

C/Ebpβ Inhibits Apoptosis in Hematopoietic Cells Via Interaction with NF-κb p50

Rebecca McFall, MD¹, Ido Paz-Priel, MD² and Alan D. Friedman, MD¹

¹Pediatric Oncology, Johns Hopkins University, Baltimore, MD
²Johns Hopkins University, Baltimore, MD

1333

PKR Promotes BCL2 Phosphatase Function in ALL Cells by Dual Mechanisms: As a B56α Kinase and by Supporting B56α Expression Via eIF2α And the PI3K/AKT Cascade

Peter P. Ruvolo, PhD and Vivian R Ruvolo^*

Signal Transd. & Apoptosis, Univ. of Minnesota, Austin, MN

1334

Overlapping but Distinct Role of p21^WAF1/CDKN1 and Survivin in Hematopoietic Progenitor Cell Proliferation

Seiji Fukuda, MD, PhD¹, Mariko Abe, MD¹^*, Seiji Yamaguchi, MD¹^* and Louis M. Pelus, PhD²

¹Dept. of Pediatrics, Shimane Univ., Izumo, Japan
²Microbiology and Immunology and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN

1335

Amelie Pia Houben^*, Anja Buchheiser^*, Murat Aktas^*, Johannes Fischer^*, Peter Wernet^* and Gesine Koegler^*

Institut für Transplantationsdiagnostik und Zelltherapeutika, Duesseldorf, Germany

1336

In Vivo Injection of Synthetic Small Interfering RNA to Lethally Irradiated Mouse as a New Model to Study Apoptotic Pathways

Michel Drouet^*, Philippe Garrigou^*, Jean-François Mayol^*, Christophe Delaunay^*, Andre Peinnequin^* and Francis Hérodin

Radiobiology, Centre de Recherches du Service de Sante des Armees, La Tronche, France

1337

Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member B (ANP32B), a Novel Caspase-3 Substrate, Exerts Anti-Apoptotic Effects on Acute Myeloid Leukemic Cells

Yun Yu¹^*, Shao-Ming Shen²^*, Li-Shun Wang¹^*, Qian Zhao¹^* and Guo-Qiang Chen¹

¹Department of Pathophysiology, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
²Shanghai Institute of health Sciences, Shanghai Institutes for Biological Sciences-Shanghai Jiao Tong University School of Medicine, Shanghai, China

1338

Influence of Prion Gene Downregulation by RNAi on Erythroid Differentiation in Vitro. First Insight

Martin Panigaj, MS^*, Hana Glierova^* and Karel Holada^*

Department of Immunology and Microbiology, Charles University of Prague, 1st Medical Faculty, Prague 2, Czech Republic

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^*signifies non-member of ASH

505.P1.17 Hematopoiesis - Apoptosis and Cell Cycle Regulation Poster