50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Hematopoiesis

Monday, December 8, 2008: 1:30 PM-3:00 PM

Gateway Ballroom 104 - South (Moscone Center)

Moderators:

Dale Bixby and Sandra Zinkel

1:30 PM

Disruption of GAS6-MER Pathway Leads to Defects in Physiological Clearance of Expelled Nuclei from Erythroblasts by Bone Marrow Macrophages

Linda Kadi¹^*, Laurent Burnier¹^*, Rocco Sugamele¹^*, Peter Carmeliet²^*, Greg Lemke³^*, H. Shelton Earp III⁴, Glenn K. Matsushima⁵^*, Marc Schapira¹ and Anne Angelillo-Scherrer¹^*

¹Service of and Central Laboratory of Hematology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
²VIB, K.U.Leuven, Vesalius Research Center, Leuven, Belgium
³Salk Institute for Biological Studies, La Jolla, CA
⁴University of NC at Chapel Hill, Lineberger Comprehensive Cancer Ctr., Chapel Hill, NC
⁵UNC Neuroscience Center, University of NC at Chapel Hill, NC

1:45 PM

500

The Role of RNA Helicase Dead Box 18 in Zebrafish Hematopoiesis and Human MDS

Elspeth Payne, MB, ChB¹^*, Niccolo Bolli, MD²^*, Clemens Grabher³^*, Jennifer Rhodes, PhD⁴^*, John Kanki⁵^*, Ilene Galinsky, ANP⁶, Richard Stone, MD⁷^*, Finbar E Cotter, FRCP, FRCPath, PhD⁸^* and A. Thomas Look, MD⁵

¹Pediatric Oncology Department, Dana Farber Cancer Institute, Boston, MA
²Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA
³Pediatric Oncology, Dana-Farber Cancer Inst., Boston, MA
⁴Dana-Farber Cancer Inst., Boston, MA
⁵Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA
⁶Dana Farber Cancer Inst., Boston, MA
⁷Dana Farber Cancer Institute, Boston, MA
⁸Centre for Haematology, Barts and The London School of Medicine, London, United Kingdom

2:00 PM

501

A Positive Feedback Loop Between C/EBPα and NF-κB p50 Inhibits Both the Intrinsic and Extrinsic Apoptosis Pathways

Ido Paz-Priel, MD, Dehua Wang, MD, Alokesh Ghosal, Ph.D.^* and Alan D. Friedman, M.D.

Pediatric Oncology, Johns Hopkins University, Baltimore, MD

2:15 PM

502

Murine Hematopoietic Stem Cells Require Akt1 and Akt2 for Long-Term Self-Renewal

Marisa M. Juntilla^*, Vineet Patil^*, Rohan Joshi^* and Gary A. Koretzky^*

Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA

2:30 PM

503

Roles of Raf/MEK/ERK and PI3K/Akt/mTOR Signaling and p53 Pathways on Apoptosis, Drug Resistance and Therapeutic Sensitivity of Early Hematopoietic Precursor Cells

Stephen Lee Abrams¹^*, Linda S Steelman, BS., MS¹^*, Melissa L Skolosky, BS¹^*, Giovanni Ligresti, PhD²^*, Massimo Libra, MD., PhD²^* and James A McCubrey, PhD³

¹Micro & Immun, East Carolina University, Greenville, NC
²Department of Biomedical Sciences, University of Catania, Catania, Italy
³School of Medicine, East Carolina University, Greenville, NC

2:45 PM

504

Druggable Genome siRNA-Screening Identifies Glybenclamide as a Radioprotector against Total Body Irradiation

Peter R McDonald, BA, AS, AB¹^*, Jian Fei Jiang, PhD²^*, Tracy Dixon³^*, Darcy Franicola³^*, Xichen Zhang³^*, Suhua Nie³^*, Laura Epperly³^*, Valerian Kagan, PhD²^*, John Lazo, PhD¹^*, Michael W Epperly, PhD³^* and Joel S Greenberger, MD³

¹Molecular Pharmacology, University of Pittsburgh, Pittsburgh, PA
²Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA
³Radiation Oncology, University of Pittsburgh, Pittsburgh, PA

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^*signifies non-member of ASH

505.O1.6 Hematopoiesis - Apoptosis and Cell Cycle Regulation