50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Hematopoiesis - Regulation of Gene Transcription Poster I

Saturday, December 6, 2008: 5:30 PM-7:30 PM

Hall A (Moscone Center)

Down-Regulation of CEBPA Expression Has a Stronger Impact on Myeloid Differentiation in Human Versus Mouse Cells: Mechanistic Implications for CEBPA Mutations in AML

Gabriela Bernadeta Iwanski, MD¹^*, Birte Niebuhr²^*, Maike Täger, PhD²^*, Susanne Roscher²^*, Carol Stocking, PhD²^* and Jorg Cammenga, MD³

¹Department of Hematology - Oncology, University Hospital Hamburg Eppendorf, 20 246 Hamburg, Germany
²Heinrich-Pette-Institut für experimentelle Virologie und Immunologie, 20 251 Hamburg, Germany
³Dept. of Gene Therapy, Lund Strategic Research Center, Lund, Sweden

1373

The GATA-1 Cofactor FOG-1 Recruits NuRD to Promote Normal Erythroid and Megakaryocyte Development and Maintain Lineage Fidelity by Restricting Mast Cell Gene Expression

Gregory D Gregory¹^*, Yuhuan Wang¹^*, Wei Hong²^*, Annarita Miccio¹^*, Alexey Bersenev¹^*, Xiang Yu¹^*, Hongxin Wang¹^*, John Choi¹^*, Suresh Shelat¹^*, Wei Tong¹^*, Mortimer Poncz¹^* and Gerd Blobel¹

¹Abramson Research Center, Children's Hosp. of Philadelphia, Philadelphia, PA
²Current address: Thomas Jefferson University, Philadelphia, PA

1374

The Cbl E3 Ubiquitin Ligase Negatively Regulates Erythropoiesis through Expression of the Foxo3a Transcription Factor

Terri D Richmond¹^*, Monica L Bailey¹^*, Wallace Y Langdon²^* and Dwayne Barber¹

¹Stem Cells & Developmental Biology, Ontario Cancer Institute, Toronto, ON, Canada
²University of Western Australia, Crawley, Australia

1375

Histone Deacetylases Are Essential for Chromatin Condensation and Enucleation in Mammalian Erythroblasts

Peng Ji, MD, PhD^*, Francisco J Sánchez-Rivera^* and Harvey F. Lodish, PhD

Whitehead Institute for Biomedical Research, Cambridge, MA

1376

Novel Role of the TAL1/SCL Transcription Factor in Murine Monocytopoiesis

Soumyadeep Dey, M.S.¹^*, David J. Curtis, MD, PhD², Stephen Jane, MD, PhD³ and Stephen J. Brandt, MD⁴

¹Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN
²Rotary Bone Marrow Rsch. Lab., RMH Research Foundation, Parkville, VIC, Australia
³Royal Melbourne Hospital, Parkville, VIC, Australia
⁴Vanderbilt Univ. Medical Ctr., Nashville, TN

1377

Distinct Epigenetic Modifications of Hematopoietic Cells Define Undifferentiated Status and Susceptibility to Epigenetic Reprogramming

Il-Hoan Oh, MD, PhD, Yun-Shin Chung^*, Tae-Min Kim^* and Kyong-Rim Kwon^*

Cell Therapy Center, Rsch. Inst. of Med. Science, Seoul, South Korea

1378

HoxB4 Effects on Hematopoietic Stem Cells Are Dependent on STAT3 Activity; A Potential Convergence of Self-Renewing Signals

Seung-Jip Yang¹^*, Seong-Hyun Hong¹^*, Ga-Young Lee¹^*, Ju-Young Jung¹^* and Il-Hoan Oh, MD, PhD²

¹Catholic Cell Therapy Center, The Catholic University of Korea, Seoul, South Korea
²Cell Therapy Center, Rsch. Inst. of Med. Science, Seoul, South Korea

1379

SCL and Associated Proteins Distinguish Active from Repressive GATA Transcription Factor Complexes

Wulan Deng¹^*, Tamara Tripic, PhD¹^*, Yong Cheng²^*, Ying Zhang²^*, Christopher Vakoc, PhD¹^*, Ross Hardison, PhD²^* and Gerd Blobel, MD, PhD¹

¹Abramson Research Center, Children's Hosp. of Philadelphia, Philadelphia, PA
²Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA

1380

GATA-2 Controls Proliferation of Megakaryocyte Progenitors and Its Expression Contributes to Human DS-AMKL

Zan Huang, PhD¹^* and John Crispino, PhD²

¹Dept Med/Div Hematol&Oncol, Northwestern University, Chicago, IL
²Medicine, Hematology/Oncology, Northwestern University, Chicago, IL

1381

Phosphorylation of Runx1 by Cyclin-Dependent Kinases Regulates Its Interaction with HDAC1 and HDAC3

Hong Guo, M.D., Ph.D.^* and Alan D. Friedman, M.D.

Pediatric Oncology, Johns Hopkins University, Baltimore, MD

1382

Bidirectional Control of Transcription Factor GATA2 and Cyclin/Cdks in Hematopoietic Cells

Naoko Minegishi, MD, PhD¹, Hideo Harigae, M.D² and Masayuki Yamamoto, MD, PhD³^*

¹Health & Welfare Science, Sendai University, Miyagi Prefecture, Japan
²Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan
³Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan

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^*signifies non-member of ASH

503.P1.33 Hematopoiesis - Regulation of Gene Transcription Poster I