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503.O1.8 Transcriptional Control of Hematopoiesis

Monday, December 8, 2008: 7:00 AM-9:00 AM
3006-3008 - West (Moscone Center)
Moderators:
Guy Sauvageau, MD, PhD and H. Phillip Koeffler, MD
7:00 AM
The microRNA144/451 Locus Enhances Nuclear FOXO3a Activity to Protect Erythroid Cells against Oxidant Stress

Camila O. dos Santos, Ph.D.1*, Duonan Yu, PhD1*, Julio Amigo, Ph.D.2*, Eugene Kandros1*, Eric R Valentine1*, Suresh Shelat, MD3*, Louis C Dore4*, Yu Yao1*, Janine D' Souza1*, Saghi Ghaffari, MD, PhD5, Barry H. Paw, M.D., Ph.D.2, Jordan S Orange, MD, PhD6* and Mitchell J. Weiss, M.D., Ph.D.1

1Division of Hematology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA
2Division of Hematology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA
3Abramson Research Center, Children's Hosp. of Philadelphia, Philadelphia, PA
4Integrated Graduate Program, Feinberg School of Medicine,, Northwestern University,, Chicago, IL
5Department of Molecular, Cell & Developmental Biology, Department of Gene and Cell Medicine, New York, NY
6Division of Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA

7:15 AM
Mef2C Is a Lineage-Restricted Target Gene of Scl/Tal1 and Regulates Megakaryopoiesis and B-Cell Homeostasis

Katrin E Rhodes1*, Christos Gekas1*, Laurraine Gereige1*, Hildur Helgadottir2*, Roberto Ferrari1*, Siavash Kurdistani1*, Encarnacion Montecino-Rodriguez1*, Rhonda Basel-Duby3*, Eric Olson3*, Stuart H. Orkin, MD4, Matteo Pellegrini, Ph.D.5* and Hanna Mikkola, MD, PhD6

1UCLA, Los Angeles, CA
2Dana-Farber Cancer Institute, Boston
3University of Texas Southwestern Medical Center, Dallas
4Dana-Farber Cancer Institute, Boston, MA
5Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA
6MCDB/ICSBM/UCLA, Los Angeles, CA

7:30 AM
Differentiation-Dependent Interactions Between Runx-1 and Fli-1 during Megakaryocyte Development

Hui Huang1*, Ming Yu1, Tyler B Moran2*, Nathan Tu3*, Thomas E Akie1* and Alan B Cantor1

1Pediatrics Hematology-Oncology, Children's Hospital Boston, Boston, MA
2Molecular and Integrative Physiology, University of Illinois, Urbana, IL
3Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA

7:45 AM
Impaired Function of Hematopoietic Stem Cells with Abrogated Hypoxia Induced Expression of Vascular Endothelial Growth Factor

Matilda Rehn, MSc1*, Kristian Reckzeh, MSc1*, André Olsson, PhD1*, Håkan Axelson, PhD2* and Jörg Cammenga, MD1

1Molecular Medicine and Gene Therapy, BMC A12, Lund Stem Cell Center, Lund University, Lund, Sweden
2Dept. Laboratory Medicine, University Hospital MAS, Lund University, Malmö, Sweden

8:00 AM
Lyl1 and Scl Dosage Is Critical for Adult Hematopoietic Stem Cell Function and Survival

George Souroullas1*, Jessica Salmon2*, David J. Curtis, MD, PhD2 and Margaret Goodell, PhD3*

1Molecular and Human Genetics, Baylor College of Medicine, Houston, TX
2Rotary Bone Marrow Rsch. Lab., RMH Research Foundation, Parkville, VIC, Australia
3Stem Cells and Regenerative Medicine, Baylor College of Medicine, Houston, TX

8:15 AM
Previously Unknown Interactions Between AML1 and MLL Provide Epigenetic Regulation of Gene Expression in Normal Hematopoiesis and in Leukemia

Gang Huang*, Shannon Elf*, Xiaomei Yan*, Lan Wang*, Yan Liu, Goro Sashida*, Alex Gural*, Silvia Menendez*, Jennifer Lee*, Youyang Yang*, Xinyang Zhao* and Stephen D. Nimer

Memorial Sloan Kettering Cancer Center, New York, NY

8:30 AM
Genome-Wide Analysis of EKLF Occupancy in Erythroid Chromatin Reveals 5', 3' and Intragenic Binding Sites in EKLF Target Genes

Andre M. Pilon, MS1*, Elliott H. Margulies, PhD2*, Hatice Ozel Abaan2*, Amy Werner-Allen2*, Tim M. Townes, PhD3, Abbie M. Frederick1*, Dewang Zhou, PhD3*, Patrick G. Gallagher, MD4 and David M. Bodine, PhD1

1Nhgri, Hematopoiesis Section, GMBB, Bethesda, MD
2Nhgri, Genome Informatics Section, GTB, Rockville, MD
3University of Alabama at Birmingham, Birmingham, AL
4School of Medicine, Yale University, New Haven, CT

8:45 AM
A Novel Transcription Factor, zbtb11 Is Critical for Neutrophil Development in Zebrafish

Duncan Carradice1*, Judith E Layton1*, Joan K Heath2* and Graham J Lieschke1*

1Cancer & Haematology Division, Walter & Eliza Hall Institute of Medical Research, Parkville, Australia
2Colon Molecular & Cell Biology Laboratory, Ludwig Institute for Cancer Research, Parkville, Australia

*signifies non-member of ASH