50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Hematopoietic Stem and Progenitor Biology II

Monday, December 8, 2008: 3:30 PM-5:30 PM

Gateway Ballroom 103 - South (Moscone Center)

Moderators:

Gay M. Crooks, MD and David Traver, PhD

3:30 PM

MTG16, a Target of the T(16;21) in Acute Myeloid Leukemia, Is Required for Hematopoietic Stem and Progenitor Cell Functions

Melissa Ann Steapleton¹^*, Isabel Moreno, PhD²^*, Brenda Chyla, PhD³^* and Scott Hiebert, PhD⁴^*

¹Vanderbilt University Cancer Center, Nashville, TN
²Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, NC
³Abbott Laboratories, Abbott Park, IL
⁴Vanderbilt Cancer Center, Nashville, TN

3:45 PM

610

C-Myc Is a Major Target of Rbm15 in the Regulation of Hematopoietic Stem Cell and Megakaryocyte Development

Chao Niu, MD, PhD¹, Jiwang Zhang, MD, PhD²^* and Stephan W. Morris, MD¹^*

¹St. Jude Children's Rsch. Hosp., Memphis, TN
²Department of Pathology and Oncology Institute, Loyola University, Stritch School of Medicine, Maywood, IL

4:00 PM

611

Regulation of Stem Cell Aging by Retinoblastoma Like-1 (p107)

Erin J. Oakley¹^*, Hartmut Geiger, PhD²^* and Gary Van Zant, PhD³

¹Physiology, University of Kentucky, Lexngton, KY
²Division of Experimental hematology and cancer biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
³Markey Cancer Center, Lexington, KY

4:15 PM

612

Inactivation of PUMA Protects Hematopoietic Stem Cells and Confers Long Term Survival in Response to High Dose γ-Irradiation

Hui Yu, MD, PhD¹^*, Hongmei Shen, PhD², Feng Xu, MD¹^*, Xiaoxia Hu, MD, PhD¹^*, Yanxin Li, PhD¹^*, Yun Ling, MS¹^*, Jian Yu, PhD³^*, Lin Zhang, PhD³^*, Gerard P. Zambetti, PhD⁴^* and Tao Cheng, MD¹^*

¹Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA
²Thomas E. Starzl Transplantation Institute, Univ. of Pittsburgh, Pittsburgh, PA
³University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA
⁴Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, TN

4:30 PM

613

Hematopoietic Cells from Ube1L-Deficient Mice Exhibit Impaired Short-Term Reconstitution Capacity Under the Stress of Bone Marrow Transplantation

Xiuli Cong, MD, PhD^*, Ming Yan^* and Xiaoyan Yin^*

Moores UCSD Cancer Center and Department of Pathology, University of California San Diego, La Jolla, CA

4:45 PM

614

Absence of the Rho GTPase Activating Protein p190-B Enhances Long Term Hematopoietic Stem Cell Engraftment

Haiming Xu¹^*, Hartmut Geiger¹^*, Kathleen Szczur¹^*, Deidra Deira¹^*, Yi Zheng¹^*, Jeffrey Settleman²^*, Edward Srour³^*, David A Williams⁴^* and Marie-Dominique Filippi¹

¹Experimental Hematology, Cincinnati Children's Research Foundation, Cincinnati, OH
²Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston
³Indiana University School of Medicine, Indianapolis
⁴Division of Hematology/Oncology Department of Pediatrics, Children's Hospital Boston and Harvard Medical School, Boston

5:00 PM

615

Rapid Mobilization of Long Term Repopulating Hematopoietic Stem Cells (HSC) with AMD15057, a Small Molecule Inhibitor of VLA4; Synergism with AMD3100 and G-CSF

Pablo A. Ramirez, MD¹, Michael Rettig, PhD¹^*, Matthew Holt²^*, Julie Ritchey²^* and John F. DiPersio, MD, PhD¹^*

¹Internal Medicine, Washington Univ. in St. Louis, Saint Louis, MO
²Department of Medicine, Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO

5:15 PM

616

GSK-3β Inhibition Activates WNT, Delays Division and Preserves the Function in Hematopoietic Stem Cell

Alla Dolnikov, Kap-hyoun Ko^*, Emma Song^*, Tiffany Holmes^* and Tracey A O'Brien

Sydney Cord & Marrow Research Facility, Centre for Children's Cancer & Blood Disorders, Sydney Children's Hospital, Sydney, Australia

See more of: Oral and Poster Abstracts

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^*signifies non-member of ASH

501.O2.8 Hematopoietic Stem and Progenitor Biology II