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501.O1.6 Hematopoietic Stem and Progenitor Biology I

Sunday, December 7, 2008: 4:30 PM-6:00 PM
Gateway Ballroom 103 - South (Moscone Center)
Moderators:
Amy Wagers and Carol Stocking
4:30 PM
Prostaglandin E2 (PGE2) Treatment Rapidly Increases the Fraction of Non-Dividing Hematopoietic Stem Cells (HSCs)Clinically Relevant Abstract

Rebecca L Porter1*, Benjamin J Frisch1*, Regis J O'Keefe, MD, PhD2* and Laura M Calvi, MD3

1Department of Pathology, University of Rochester, Rochester, NY
2Center for Musculoskeletal Research, University of Rochester, Rochester, NY
3Univ. of Rochester, Sch. of Med., Rochester, NY

4:45 PM
Prostaglandin E2 Enhances Survival, Proliferation, Homing and Engraftment of Mouse Hematopoietic Stem CellsClinically Relevant Abstract

Jonathan Hoggatt, MS*, Pratibha Singh, PhD*, Janardhan Sampath, PhD* and Louis M. Pelus, PhD

Microbiology and Immunology and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN

5:00 PM
LRF Regulates Self-Renewal of Hematopoietic Stem Cells by Blocking Notch1-Mediated T Cell Differentiation

Sung-UK Lee, PhD1*, Manami Maeda, MD, PhD1*, Nagisa Sakurai, PhD1*, Julie Teruya-Feldstein, MD2*, Freddy Radtke, PhD3* and Takahiro Maeda, MD, PhD1

1HSC and Leukemia Research, City of Hope National Medical Center, Duarte, CA
2Dept. of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY
3Swiss Institute for Experimental Cancer Research, Epalinges, Switzerland

5:15 PM
CD81 Is Essential for HSC Self-Renewal through Suppressing Proliferation

Kuanyin Karen Lin1*, Lara Rossi1* and Margaret A. Goodell, PhD2

1Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX
2Center for Cell and Gene Therapy, Houston, TX

5:30 PM
Slit2 Increases Hematopoietic Stem Cell Numbers in Mice

Amanda J Waterstrat1*, Ying Liang2*, Hartmut Geiger, PhD3* and Gary Van Zant, PhD2

1Physiology, University of Kentucky, Lexington, KY
2Markey Cancer Center, Lexington, KY
3Division of Experimental hematology and cancer biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

5:45 PM
Pleiotrophin Is a Growth Factor for Hematopoietic Stem Cells and Induces Stem Cell Self-RenewalClinically Relevant Abstract

Heather A Himburg, PhD1*, Garrett Muramoto, BS2*, Sarah Kristen Meadows, BS3*, Alice Bryn Salter2*, Nelson J Chao, MD, MBA4* and John Chute, MD5

1Medicine, Division of Cellular Therapy, Duke University, Durham, NC
2Duke University, Durham, NC
3Medicine, Duke University Medical Center, Durham, NC
4Division of Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC
5Cellular Therapy, Duke University Medical Center, Durham, NC

*signifies non-member of ASH