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401.P1.33 Basic Science and Clinical Practice in Blood Transfusion Poster I

Saturday, December 6, 2008: 5:30 PM-7:30 PM
Hall A (Moscone Center)
p38 MAPK Inhibition Prevents TACE-Mediated Receptor Shedding and Improves the Hemostatic Function of Stored Platelets

Matthias Canault, PhD1*, Daniel Duerschmied, MD1*, Alexander Brill, PhD1*, Ian Sean Patten1*, Wolfgang Bergmeier, PhD2 and Denisa D. Wagner, PhD1

1Harvard Medical School, Immune Disease Institute, Boston, MA
2Thomas Jefferson University, Philadelphia, PA

Rejuvenation of Aged Human Red Cells Improves Their in Vivo Recovery in a Mouse Model

Monique Gelderman-Fuhrmann, PhD1 and Jaroslav G. Vostal, MD, PhD2

1Lab. of Cellular Hematology, Food & Drug Administration, Rockville, MD
2Lab. of Cellular Hem., Bethesda, MD

Carbon Nanotubes Activate Platelets by Facilitating Extracellular Ca2+ Influx

Jana Semberova, M.D.1*, Karel Holada, PhD2, Olga Simakova, Ph.D.3*, Monique P. Gelderman-Fuhrmann, Ph.D.1* and Jan Simak, Ph.D.1

1Lab. of Cellular Hematology, CBER FDA, Rockville, MD
2Inst. of Immunology and Microbiology, Charles University, Prague, Czech Republic
3USUHS, Bethesda, MD

From Venus and Mars: Gender Specific Analysis of Blood Platelets

Peter Schubert, PhD, Danielle Coupland*, Geraldine M. Walsh, PhD*, Cindy Chen* and Dana V. Devine, PhD

Univ. of British Columbia, Canadian Blood Services, Vancouver, BC, Canada

Phase 1 Clinical Trial of Prion-Filtered Red Cell Concentrates (pfRCC) in Patients Requiring Allogeneic Blood Transfusion

Tracy Murphy1*, Mary R Cahill1*, Jim Fagan2*, Croxon Harry2*, Mohammed Khan1*, Oonagh Gilligan1*, Stephen McGrath1* and William G Murphy2*

1Department of Haematology, Cork, Ireland
2National Blood Centre, Dublin 8, Ireland

Efficient Reduction of Prions by the Manufacturing Process of a VWF/FVIII Product

Albrecht Groener1, Martin Groschup2* and Wolfram Schäfer1*

1Virology, CSL Behring, Marburg, Germany
2Institute for Novel and Emerging Infectious Diseases at the Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald - Insel Riems

Platelet Activation Rather Than Apoptosis Contributes Most to the Platelet Storage Lesion during Conventional and Extended Storage of Platelet Concentrates

Valery Leytin1, David J. Allen1*, Asuman Mutlu1*, Sergiy Mykhaylov1*, Elena Lyubimov1*, Armen V. Gyulkhandanyan1* and John Freedman, MD2

1Transfusion and Laboratory Medicine, The Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, ON, Canada
2Departments of Laboratory Medicine and Pathobiology, Medicine, St. Michael's Hospital and University of Toronto, Toronto, ON, Canada

Dynamic Pattern of Adhesion Receptor Expression during the Maturation of Ex-Vivo Generated Human Adult and Neonatal Erythroid Cells

Giovanni Migliaccio, Ph.D.1*, Massimo Sanchez, Ph.D1*, Francesca Masiello, Ph.D.1*, Valentina Tirelli, Ph.D1*, Katija Iliecic, Ph.D.2*, Annalisa Mancini, Ph.D.3*, Paul S. Frenette, MD3 and Anna Rita Migliaccio, Ph.D.3*

1Cell Biology and Neuroscience, Istituto Superiore di Sanita', Rome, Italy
2Hematology/Oncology and Molecular Medicine, Istituto Superiore di Sanita', Rome, Italy
3Medicine, Mount Sinai School of Medicine, New York, NY

Sensitive and Simple Methodologies for Measuring of Red Blood Cell (RBC) Electrical Properties and Cell Aggregation

Heloise Pockel Fernandes, Bsc1*, Adriana Fontes, PhD2*, André A Thomaz, Msc3*, Luiz C Barbosa, PhD3*, Vagner Castro, MD, PhD4, Carlos Lenz Cesar, PhD3* and Maria Lourdes Barjas-Castro, MD, PhD5

1Department of Pharmacology, State University of Campinas - UNICAMP, Campinas - SP, Brazil
2Departamento de Biofísica e Radiobiologia, Universidade Federal de Pernambuco - UFPE, Recife - PE, Brazil
3Departamento de Eletrônica Quântica, Universidade Estadual de Campinas - UNICAMP, Campinas - SP, Brazil
4Dept. of Hematology/Transf Medicine Ctr., State Univ. of Campinas - UNICAMP, Campinas, Brazil
5Trans. Med., Carlos Chagas 480, Hem. Unicamp - State Univ. of Campinas, Campinas, Sao Paulo, Brazil

Effect of Storage on Levels of Nitric Oxide Derivatives in Blood Components

Fabiola G Rizzatti, MD1*, Melissa A Qazi, BS1*, David Stroncek, MD2*, Nathawut Sibmooh, MD1*, Barbora Piknova, PhD1* and Alan N Schechter, MD1

1Molecular Medicine Branch, National Institutes of Health - National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD
2Transfusion Medicine, National Institutes of Health, Bethesda, MD

*signifies non-member of ASH