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401.O1.8 Transfusion Medicine: Basic Science and Clinical Practice

Monday, December 8, 2008: 7:00 AM-9:00 AM
3014-3016-3018 - West (Moscone Center)
Moderators:
Christine Cserti, MD, HBSc and Janice McFarland, MD
7:00 AM
285
Effects of Prophylactic Platelet (Plt) Dose on Transfusion (Tx) Outcomes (PLADO Trial)

Sherrill J. Slichter, MD1, Richard M. Kaufman, MD2, Susan F. Assmann, PhD3, Mark E. Brecher, MD, BC4, Terry Gernsheimer, MD1, Christopher D. Hillyer, MD5, Jeffrey McCullough, MD6, Ronald G. Strauss, MD7 and Darrell Triulzi, MD8*

1Puget Sound Blood Center, Seattle, WA
2Brigham and Women's Hosp., Boston, MA
3Ctr. for Statistics & Applied Research, New England Rsch. Insts., Watertown, MA
4UNC Hospitals, Chapel Hill, NC
5Emory University Hospital, Atlanta, GA
6University of Minnesota, Minneapolis, MN
7University of Iowa Hosp., Iowa City, IA
8Institute for Transfusion Medicine, Pittsburgh, PA
7:15 AM
286
A Therapeutic Platelet Transfusion Strategy without Routine Prophylactic Transfusion Is Feasible and Safe and Reduces Platelet Transfusion Numbers Significantly: Preliminary Analysis of a Randomized Study in Patients after High Dose Chemotherapy and Autologous Peripheral Blood Stem Cell Transplantation

Hannes Wandt, MD1*, Knut Wendelin, MD1*, Kerstin Schaefer-Eckart, MD1, Markus Thalheimer, MD2*, Mario Stephan Schubert, MD2*, Roland Conradi, MD3*, Rainer Schwerdtfeger, MD3, Lothar Leimer, MD4*, Martin Kaufmann, MD4*, Gottfried Dölken, MD5*, Anne Friederike Klenner, MD5*, Markus Schaich, MD6 and Gerhard Ehninger, MD6

1Medical Department 5, Klinikum Nuernberg Nord, Nuernberg, Germany
2Medical Department 5, University Heidelberg, Germany
3DKD Wiesbaden, Germany
4Robert Bosch Krankenhaus, Stuttgart, Germany
5Hematology/Oncology, University Greifswald, Germany
6Medical Clinic 1, Technic University Dresden, Germany
7:30 AM
287
Post-Transfusion Viability of 7-Day Stored Platelet (Plt) Concentrates Prepared after An Overnight Hold of Whole Blood (WB) at 22°CClinically Relevant Abstract

Sherrill J. Slichter, MD, Jill Corson, RN*, Mary Kay Jones, MT(ASCP)*, Esther Pellham, BS*, Todd Christoffel, MT(ASCP)*, Shawn Bailey, BS* and Doug Bolgiano, MS*

Puget Sound Blood Center, Seattle, WA
7:45 AM
288
Transfusion-Related Acute Lung Injury (TRALI) Requires Heterotypic Interactions of Platelets with Specific Neutrophil Microdomains

Andres Hidalgo, PhD and Paul S. Frenette, MD, FRCPC

Mount Sinai School of Medicine, New York, NY
8:00 AM
289
RASSF1a Is Applicable as Universal Fetal Identifier in RQ-PCR-Based Non-Invasive Prenatal Genotyping Assays

Aicha Ait Soussan1*, Bernadette Bossers1*, Ahmed Tissoudali1*, Godelieve C Page-Christiaens2*, Masja de Haas1* and C. Ellen Van der Schoot1*

1Experimental Immunohematology, Sanquin Research, Amsterdam, Netherlands
2Division of Perinatology and Gynecology, University Medical Centre Utrecht, Utrecht, Netherlands
8:15 AM
290
Analysis of Naturally Processed HPA-1a Peptides Bound to Human MHC Class II Molecules

Gholamreza Anani Sarab*, Robert N Barker, BSc, PhD*, Michael Moss, BSc, PhD* and Stanislaw Urbaniak, MBChB, PhD, FRCP, FRCPath

Department of Medicine & Therapeutics, University of Aberdeen, Aberdeen, United Kingdom
8:30 AM
291
Synthetic Peptide Mimotopes of blood Group Antigens for Red Cell Antibody ScreeningClinically Relevant Abstract

Evelyn J A Tait, BSc, PhD1*, Robin Fraser, BSc, PhD2*, Michael Moss, BSc, PhD1* and Stanislaw J Urbaniak, MBChB, PhD, FRCP, FRCPath1

1Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, United Kingdom
2Research & Development, Scottish National Blood Transfusion Service, Glasgow, United Kingdom
8:45 AM
292
Berkeley Mice with Sickle Cell Disease Are Not More Immunizable to Transfused HOD Red Blood Cells Than Sickle Trait Control Mice

Jeanne Hendrickson, MD1, David R. Archer, PhD2, Jennifer R. Perry3*, Christopher D. Hillyer, MD4 and James C. Zimring, MD, PhD5

1Emory, Atlanta, GA
2Emory University, Atlanta, GA
3Pediatrics, Emory University School of Medicine, Atlanta, GA
4Emory University Hospital, Atlanta, GA
5Emory University Sch. of Med., Atlanta, GA
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*signifies non-member of ASH