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322.P1.66 Disorders of Coagulation or Fibrinolysis Poster I

Saturday, December 6, 2008: 5:30 PM-7:30 PM
Hall A (Moscone Center)
Recombinant Interleukin-11 (rhIL-11) in Women with Refractory Menorrhagia and Von Willebrand DiseaseClinically Relevant Abstract

Rachel C. Jankowitz, MD1, Margaret V. Ragni, MD, MPH2, Holly L. Chapman, RN3*, Elizabeth P. Merricks, BS4*, Mark T. Kloos, BS4*, Aaron M. Dillow, BS4*, Helen Franck, BS4* and Timothy C. Nichols, MD4

1Department of Medicine, Division Hematology/Oncology, University of Pittsburgh, Pittsburgh, PA
2Department of Medicine, Division Hematology/Oncology, University of Pittsburgh and Hemophilia Center of Western PA, Pittsburgh, PA
3Medicine, University of Pittsburgh and Hemophilia Center of Western PA, Pittsburgh, PA
4Francis Owen Blood Research Lab, University of North Carolina, Chapel Hill, NC

B-Cell Epitope Mapping of Monoclonal Anti-Factor VIII C2 Domain Inhibitors: Identification of Amino Acids That Contribute Significant Antigen-Antibody Binding Affinity

Jasper C. Lin, Ph.D.1*, Jason T. Schuman, Ph.D.2*, Shannon L. Meeks, M.D.3*, John F. Healey3*, Arthur R. Thompson, M.D., Ph.D.1 and Kathleen P. Pratt, Ph.D.1

1Puget Sound Blood Center, Seattle, WA
2GE Healthcare Life Sciences
3Emory University, Atlanta, GA

HLA-DRB1*1101-Restricted T Cells from Two Unrelated Mild Hemophilia a Inhibitor Subjects with Missense Genotype R593C Respond to the Same Minimal Epitope

Eddie A. James, Ph.D.1*, Simon D. van Haren2*, Ruth A. Ettinger, Ph.D.3*, Arthur R. Thompson, M.D., Ph.D.3, William W. Kwok, Ph.D.1*, Jan Voorberg, Ph.D.2* and Kathleen P. Pratt, Ph.D.3

1Benaroya Research Institute, Seattle, WA
2Sanquin Research, 1066 CX Amsterdam, Netherlands
3Puget Sound Blood Center, Seattle, WA

Circulating Microparticles in Snake Bite Patients  with Microangiopathy

Anoop Enjeti, MBBS, MD, FRCPA1, Fiona Scorgie2*, Lisa Lincz3*, Simon Brown4*, Geoff Isbister5* and Michael Seldon6*

1Dept. of Haematology, Hunter Haematology Research Group, Calvary Mater Hospital Newcastle, Waratah, Australia
2Hunter Haematology Research Group, Calvary Mater Hospital, Waratah, Australia
3Hunter Haematology Reserch GroupUnit, Calvary Mater Hospital Newcastle, Waratah, Australia
4Centre for Clinical Research in Emergency Medicine, Institute for Medical Research and the University of Western Australia, Perth, Australia
5Emergency Medicine/ Toxicology, Calvary Mater Hospital Newcastle, Waratah, Australia
6Haematology, Hunter Haematology Unit, Calvary Mater Hospital Newcastle, Waratah, Australia

Biomarkers of Cartilage and Bone Damage as a Measure of Joint Damage in Haemophilia

Nathalie W.D. Jansen, PhD1*, Goris Roosendaal, MD, PhD1*, Bjorn Lundin, MD, PhD2*, Lily Heijnen, MD, PhD1*, Matthias Theobald, MD, PhD1, Johannes W.J. Bijlsma, MD, PhD3* and Floris P.J.G. Lafeber, PhD3*

1Hematology and Van Creveldkliniek, University Medical Center Utrecht, Utrecht, Netherlands
2Diagnostic Radiology, Lund University Hospital, Lund, Sweden
3Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands

Patients with Severe Factor XI Deficiency Who Have An Inhibitor or IgA Deficiency Can Undergo Uneventful Major Surgery by a Single Infusion of Low Dose Recombinant Factor VIIa and Use of Tranexamic Acid

Ophira Salomon1, Ilia Tamarin1*, Tami Livnat1*, Zeev Horovitz2*, Joseph Kuriansky3*, Uriel Martinowitz1*, Yoram Mor4* and Uri Seligsohn1*

1Institute of Thrombosis and Hemostasis, Hematology, Ramat Gan, Israel
2Ear, Nose and Throat Institute, Ramat Gan, Israel
3Surgery Department, Ramat Gan, Israel
4Department of Urology, Ramat Gan, Israel

Atherosclerosis and Predictors of Cardiovascular Mortality in Hemophilia

Carolyn Foley, BS1*, Lawrence A. Nichols, MD2* and Margaret V. Ragni, MD, MPH3

1Medicine, Division Hematology, Oncology, University of Pittsburgh and Hemophilia Center of Western PA, Pittsburgh, PA
2Pathology, University of Pittsburgh, Pittsburgh, PA
3Department of Medicine, Division Hematology/Oncology, University of Pittsburgh and Hemophilia Center of Western PA, Pittsburgh, PA

Pre-Surgical PK Analyses in VWD Patients Undergoing Surgery Do Not Reliably Guide Dosing Due to Intra-Individual Variability in in-Vivo Recovery of VWF:RCo

Jorge DiPaola, MD1*, Marilyn J. Manco-Johnson, MD2, Joan Cox Gill3* and Garrett E. Bergman, MD, MBA4

1Pediatrics, University of Iowa Hospital and Clinics, Iowa City, IA
2Mountain State Regional Hemophilia and Thrombosis Center, University of Colorado, Aurora, CO
3BloodCenter of Wisconsin, Milwaukee, WI
4CSL Behring LLC, King of prussia, PA

Population Pharmacokinetic Modeling of BeneFIX in Pediatric and Adult Patients with Hemophilia B Demonstrates Weight as An Important Factor Contributing to Inter-Patient PK Variability

Chandrasekhar Udata, PhD1*, Sharon Sullivan, PhD2*, Patrick Kelly, MD2, David A. Roth, MD2 and Xu Meng, PhD1*

1Wyeth Research, Collegeville, PA
2Wyeth Research, Cambridge, MA

Prospective Evaluation of Chromosomal Breakages in Hemophiliac Children after Radioisotope Synovectomy with Yttrium90 and Rhenium186

Kaan Kavakli, MD1, Ozgur Cogulu, MD2*, Semih Aydogdu, MD3*, Hayal Ozkilic, MD4*, Burak Durmaz2*, Ozgur Kirbiyik2*, Ferda Ozkinay, MD2*, Can Balkan, MD1*, Deniz Yilmaz Karapinar, MD1*, Yilmaz Ay, MD1* and Mehmet Akin, MD1*

1Dept. Hematology, Bornova, Izmir, Turkey
2Dept. Medical Genetics, Ege University, Izmir, Turkey
3Dept. Orthopedics, Ege University Hospital, Izmir, Turkey
4Dept. Nuclear Medicine, Ege University Hospital, Izmir, Turkey

Unraveling the Danger Signal Necessary for the Immune Response to Therapeutic Factor VIII

Jonathan Skupsky, BS1*, Ai-Hong Zhang, MS, PhD2* and David W. Scott, PhD3

1Program in Molecular Medicine, MD/PhD Program, University of Maryland School of Medicine, Baltimore, MD
2Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimre, MD
3Depts. of Surgery & Microbiology-Immunology, University of Maryland School of Medicine, Baltimore, MD

Investigator-Prescribed Prophylaxis of rFIX (BeneFIX®) in Children <6 Years of Age: Efficacy and Safety Outcomes

Paul E. Monahan, MD1, Raina Liesner, MD2*, Sharon Sullivan, PhD3*, Brooke Hayward, SM3*, Maria E. Ramirez, PhD, MPH3*, Patrick Kelly, MD3 and David A. Roth, MD3

1Gene Therapy Center, University of North Carolina, Chapel Hill, NC
2Great Ormond Street Hospital for Children, London, United Kingdom
3Wyeth Research, Cambridge, MA

Effect of Normal Variation in Factor VIII Pharmacokinetics on Prophylactic Dosing Requirements in Severe Classical Hemophilia

Peter Collins1*, Kathelijn Fischer, MD, PhD, MSC2*, Victor S. Blanchette, FRCP3, Sven Björkman4*, Myungshin Oh5*, Phillip Schroth5*, Kathleen M. Casey, PhD5, Gerald Spotts, PhD5, Sandor Fritsch5* and Bruce M. Ewenstein, MD, PhD5

1Haematology, University Hospital of Wales, Cardiff, United Kingdom
2Van Creveldkliniek, UMCU, Utrecht, Netherlands
3Hospital for Sick Children, Toronto, ON, Canada
4Dept of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
5Baxter BioScience, Westlake Village, CA

AV513 Promotes Tissue Factor-Mediated Coagulation in Fresh Human Whole Blood from Severe and Moderate Hemophilia a Subjects

Jerry Sherman Powell, MD1, Sabine Knappe, PhD2*, Janet A Harrison, BS1*, Susannah Patarroyo-White, BS2*, Kirk Johnson, PhD2 and Srinivasa Prasad, PhD2

1University of California at Davis, Sacramento, CA
2R&D, Avigen Inc, Alameda, CA

Peptide Multimers for Binding of Factor VIII Inhibitors

Christoph Kessel1*, Wolfhart Kreuz2*, Katharina Klich1*, Frank Vorpahl1*, Karin Becker-Peters1*, Ursula Dietrich3*, Thomas Klingebiel4 and Christoph Königs1*

1Molecular Hemostasis, Comprehensive Care Center for Thrombosis and Hemostasis, Center of Pediatrics III, Johann Wolfgang Goethe-University Hospital, Frankfurt am Main, Germany
2Comprehensive Care Center for Thrombosis and Hemostasis, Center of Pediatrics III, Johann Wolfgang Goethe-University Hospital, Frankfurt am Main, Germany
3Georg-Speyer-Haus, Institute for Biomedical Research, Frankfurt am Main, Germany
4Center for Pediatrics III, Johann Wolfgang Goethe-University Hospital, Frankfurt am Main, Germany

Effects of Angiotensin-Converting Enzyme Inhibition on Thromboelastogaphy for Infants and Children Presenting for Elective Cardiac Surgery

Michael L Schmitz, MD1*, Edgar D St. Amour, M.Sc.2*, Kimo Stine, MD3, Mark A Austen, MS4*, Chanhee Jo, PhD4*, Pamela Killebrew, RNP1* and Robert J Jaquiss, MD5*

1Anesthesiology, Arkansas Children's Hospital, Little Rock, AR
2Anesthesiology, Arkansas Childrens Hospital
3Pediatric Hematology-Oncology, Arkansas Children's Hospital, Little Rock, AR
4Biostatistics, Arkansas Children's Hospital, Little Rock, AR
5Surgery, Arkansas Children's Hospital, Little Rock, AR

Detection of F8 Mutations by High Resolution Melting (HRM) Analysis

Patricia A Bignell, Clinical, Scientist1*, David M. Keeling, MD2 and Paul Giangrande, MD3*

1Haemophilia Genetics, Oxford Thrombosis and Haemophilia Centre, Oxford, United Kingdom
2Oxford Haemophilia and Thrombosis Centre, Oxford, ARRAY(0xa0899f8)
3Oxford Haemophilia and Thrombosis Centre, Oxford

Fibrinogen Concentrate Corrects Dilutional Coagulopathy: A Prospective, Randomized Placebo Controlled Clinical Trial

Christian Fenger-Eriksen, MD1*, Tommy Midtgaard Jensen2*, Bo Kristensen2*, Klaus Møller Jensen3*, Else Tønnesen2*, Jørgen Ingerslev, MD4 and Benny Sorensen, M.D., Ph.D.5*

1Center for Haemophilia and Thrombosis, Aarhus University Hospital, Aarhus N, Denmark
2Department of Anaesthesiology, Aarhus University Hospital, Aarhus, Denmark
3Department of Urology, Aarhus University Hospital, Aarhus, Denmark
4University Hospital Skejby, Aarhus, Denmark
5Center for Haemophilia and Thrombosis, Skejby Hospital and Aarhus University, Aarhus, Denmark

Celecoxib Does Not Delay Cutaneous Wound Healing in Hemophilia B Mice

Shan Pradhan, MD1*, Maureane Hoffman, MD, PhD2 and Dougald M. Monroe III, PhD1

1Medicine, University of North Carolina, Chapel Hill, NC
2Pathology & Lab Medicine, Durham VA Medical Center, Durham, NC

BDDrFVIII [moroctocog alfa (AF-CC), Xyntha] for Surgical Hemostasis in Patients with Hemophilia A: Results from a Pivotal Study

Jerzy Windyga, MD, PhD1*, Luminita Rusen, MD, PhD2*, Amanda C. O'Brien3*, Brooke Hayward, SM3*, Steven Arkin, MD3 and David A. Roth, MD3

1Center for Hemophilia Treatment, Institute of Hematology and Blood Transfusion, Warsaw, Poland
2National Institute for Transfusional Hematology, Bucharest, Romania
3CR&D, Wyeth Research, Cambridge, MA

*signifies non-member of ASH