50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Von Willebrand Disease and Other Coagulation Disorders

Monday, December 8, 2008: 11:00 AM-12:30 PM

3020-3022-3024 - West (Moscone Center)

Moderators:

Nicole Hasbrouck and W. Keith Hoots, MD

11:00 AM

Annexin A2 Deficient Mice Are Resistant to Pathogenic Effects of Antiphospholipid Antibodies in Vivo

Zurina Romay-Penabad, Ph.D.¹^*, Guadalupe Montiel-Manzano, M.S.¹^*, Elizabeth Pappalardo, B.S.¹^*, Katherine A. Hajjar, MD², Tuya Shilagard, Ph.D.³^*, Gracie Vargas, Ph.D.³^* and Silvia S Pierangeli, Ph.D.¹

¹Rheumatology/Internal Medicine, University of Texas Medical Branch, Galveston, TX
²Cell and Developmental Biology, Weill Cornell Medical College, New York, NY
³Center for Biomedical Engineering, University of Texas Medical Branch, Galveston, TX

11:15 AM

422

Hereditary Deficiencies of Protein C or Protein S Confer Increased Risk of Arterial Thromboembolic Events at Young Age. Results from a Large Family Cohort Study

Bakhtawar Khan Mahmoodi^*, Jan-Leendert P. Brouwer^*, Nic J.G.M. Veeger^* and Jan van der Meer^*

Division of Hemostasis, Thrombosis and Rheology, Department of Hematology, University Medical Center Groningen, Groningen, Netherlands

11:30 AM

423

Unique ELISA-Based Assays for VWF-GPIb Interactions and the Impact of Racial Differences on VWF Testing

Veronica H. Flood, MD, Patricia A. Morateck^*, Pamela A. Christopherson^*, Kenneth D. Friedman, MD, Joan Cox Gill, MD^*, Robert R. Montgomery, MD and The Zimmerman Program Investigators^*

TS Zimmerman Program for the Molecular and Clinical Biology of VWD, Blood Research Institute, Medical College of Wisconsin, Milwaukee, WI

11:45 AM

424

Characterisation of W1745C and S1783A, Two Novel Collagen Binding Defects in the A3 Domain of Von Willebrand Factor

Anne Riddell¹^*, Keith Gomez¹^*, Carolyn Millar¹^*, G. Mellars¹^*, Simon A Brown¹^*, Saher Gill²^*, Michael Laffan³ and Thomas A J McKinnon²^*

¹Hemophilia Ctr. & Thrombosis Unit, The Royalfree Hospital, London, United Kingdom
²Haematology, Imperial College London, London, United Kingdom
³Dept. of Hematology, Imperial College School of Med., London

12:00 PM

425

Bleeding Scores in Von Willebrand Disease (VWD) Re-Visited: Analysis of the TS Zimmerman Program for the Molecular and Clinical Biology of VWD

Joan Cox Gill, MD, Pamela A Christopherson^*, Veronica H Flood, MD^*, Kenneth D Friedman, MD, Robert R. Montgomery, MD and The Zimmerman Program Investigators^*

TS Zimmerman Program for the Molecular and Clinical Biology of VWD, Blood Research Institute, Medical College of Wisconsin, Milwaukee, WI

12:15 PM

426

Suman Sood, MD¹^*, Adam Cuker, MD¹^*, Chengbin Wang, Ph.D.²^*, Ara Metjian, MD³, Elaine Y Chiang¹^*, J. Michael Soucie, Ph.D.²^*, Barbara A. Konkle, MD¹ and Htcn Investigators⁴^*

¹Division of Hematology-Oncology, University of Pennsylvania, Philadelphia, PA
²Division of Blood Disorders, Centers for Disease Control and Prevention (CDC), Atlanta, GA
³Division of Hematology, Duke University School of Medicine, Durham, NC
⁴Hemophilia Treatment Center, Multiple Institutions, Multiple Cities

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^*signifies non-member of ASH

322.O2.6 Von Willebrand Disease and Other Coagulation Disorders