50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Blood Coagulation and Fibrinolytic Factors Poster I

Saturday, December 6, 2008: 5:30 PM-7:30 PM

Hall A (Moscone Center)

Endothelial Cell Protein C Receptor Cellular Localization and Trafficking

Ramesh Nayak, PhD¹^*, Prosenjit Sen, PhD¹^*, Charles Esmon, PhD², Usha Pendurthi, PhD¹ and L. Vijaya Mohan Rao, PhD¹

¹Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, TX
²Howard Hughes Med. Inst., Oklahoma City, OK

1016

Enhancement of Factor VIII Stability by Replacing Multiple Charged Residues at the A2 Domain Interface

Hironao Wakabayashi, MD, PhD, Amy E Griffiths, MS^* and Philip Fay, PhD

Biochemistry & Biophysics, University of Rochester, Rochester, NY

1017

Factor VIII and Factor IX Mutation Analysis in 600 U.S. Hemophilia Patients: Correlation of Mutation Type with History of Inhibitor

Connie H. Miller, PhD¹^*, Craig Hooper, PhD¹^*, Thomas C. Abshire, MD², Paula L. Bockenstedt, MD³, Doreen B. Brettler, MD⁴, Jorge Di Paola, MD⁵, Gita Massey, MD⁶, Anne T. Neff, MD⁷, Amy D. Shapiro, MD⁸, Michael Tarantino, MD⁹, Brian M. Wicklund, MD, MPH¹⁰, Marilyn J. Manco-Johnson, MD¹¹, Amy L. Dunn, MD²^*, Christine Knoll, MD¹²^*, Melissa Creary, MPH¹^*, Jane Benson¹^*, Dorothy Ellingsen¹^*, Jennifer Driggers¹^* and J. Michael Soucie, PhD¹^*

¹Division of Blood Disorders, NCBDDD, Centers for Disease Control & Prevention, Atlanta, GA
²Emory University School of Medicine, Atlanta, GA
³University of Michigan Medical Center, Ann Arbor, MI
⁴Memorial Healthcare, Worcester, MA
⁵Univ. of Iowa Hosp. & Clinics, Iowa City, IA
⁶VCU, Med. College of VA, Richmond, VA
⁷Vanderbilt Univ. Med. Ctr., Nashville, TN
⁸Indiana Hemophilia & Thrombosis Ctr., Indianapolis, IN
⁹Comprehensive Bleeding Disorders Center, Peoria, IL
¹⁰Children's Mercy Hospital, Kansas City, MO
¹¹Mountain State Regional Hemophilia and Thrombosis Center, University of Colorado Denver, Aurora, CO
¹²Phoenix Children's Hospital, Phoenix, AZ

1018

Characterization of Heparin Binding Site Residues on the Catalytic Domain of Factor XIa

Likui Yang, Ph.D.¹^*, Mao-fu Sun²^*, Chandrashekhara Manithody, Ph.D.¹^*, David Gailani, MD² and Alireza R. Rezaie, PhD¹

¹Biochemistry and Molecular Biology, St. Louis University School of Medicine, St. Louis, MO
²Pathology and Medicine, Vanderbilt University, Nashville, TN

1019

Enhanced Fibrinolysis of Coarse Fibrin Networks Reflects Cleavage of a B Knob Containing Fragment(s)

Dennis K. Galanakis, MD¹, Marguerite Neerman-Arbez, Ph, D²^*, Agnes Henschen³^* and Bodan Kudryk, Ph, D⁴^*

¹Blood Bank, SUNY at Stony Brook, Stony Brook, NY
²Medicine, University Medical Centre, Geneva,, Switzerland
³Molec. Biology and Biochemistry, Univ. of California at Irvine, Irvine, CA
⁴Medicine, New York Blood Center, New York, NY

1020

The Effect of Factor Va on Prothrombinase Function

Michael Kalafatis, PhD, Jamila Hirbawi, BS^*, Melissa A. Barhoover, PhD^* and Michael A. Bukys, PhD^*

Cleveland State University, Cleveland, OH

1021

Thrombin Cleavage at Arg1689 Influences Subsequent Cleavage at Arg372 during Activation of Factor VIII

Jennifer L. Newell, MS^* and Philip Fay, PhD

Biochemistry and Biophysics, University of Rochester, Rochester, NY

1022

The Nature of LPS-Stimulated Monocyte Tissue Factor Activity

Saulius Butenas, PhD^*, Behnaz Parhami-Seren, PhD^*, Matthew T. Gissel^*, Jolanta Amblo^*, Kathleen E. Brummel-Ziedins, PhD^* and Kenneth G. Mann, PhD

Biochemistry, University of Vermont, Colchester, VT

1023

Plasminogen Activator Inhibitor-1 Inhibits Factor VIIa Bound to Tissue Factor

Prosenjit Sen, Ph.D.^*, Andrey Komissarov, Ph.D.^*, Usha R. Pendurthi, Ph.D., Steven Idell, M.D., Ph.D.^* and L. Vijaya Mohan Rao, Ph.D.

Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, TX

1024

Plasma Procofactor Activation by Factor Xla

Matthew F Whelihan¹^* and Kenneth G. Mann, PhD²

¹Biochemistry Department, University of Vermont, Colchester, VT
²University of Vermont, Colchester, VT

1025

Quantitation of Non-Inhibitory Anti-Factor VIII Antibodies in human Plasma

Jolanta Krudysz-Amblo¹^*, Behnaz Parhami-Seren, Ph.D.¹^*, Saulius Butenas, Ph.D.¹^*, Kathleen E. Brummel-Ziedins, PhD²^*, Edward D. Gomperts, MBBCH, MD³, Georges E. Rivard, MD⁴ and Kenneth G. Mann, PhD⁵

¹Biochemistry Department, University of Vermont, Colchester, VT
²Dept. of Biochemistry, University of Vermont, Colchester, VT
³Children's Hospital LA, Los Angeles, CA
⁴Centre Hospitalier Universitaire Sainte Justine, Montreal, QC, Canada
⁵University of Vermont, Colchester, VT

1026

Tissue Specific Expression of Alternatively Spliced Forms of Tissue Factor Pathway Inhibitor (TFPI) in Mice

Susan A. Maroney¹, Josephine P. Ferrel¹^*, Shuchong Pan²^*, Thomas A. White²^*, Robert D. Simari²^*, John H McVey³^* and Alan E Mast¹

¹Blood Center of Wisconsin, Milwaukee, WI
²Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN
³Experimental and Translational Research, Thrombosis Research Institute, London SW3 6LR, England

1027

Role of Adaptive Regulatory T Cells in the Induction of Tolerance to FVIII

Jonathan Skupsky, BS¹^*, Elika Farrokhi, BS²^* and David W. Scott, PhD²

¹Program in Molecular Medicine, University of Maryland School of Medicine, Baltimore, MD
²Department of Surgery and of Microbiology/Immunology, University of Maryland School of Medicine, Baltimore, MD

1028

Mechanisms of Factor VIII Activation by Recombinant Factor VIIa Analog through Tissue Factor-Independent Manner

Kenichi Ogiwara^*, Keiji Nogami^*, Tetsuhiro Soeda^*, Tomoko Matsumoto^*, Katsumi Nishiya^* and Midori Shima

Department of Pediatrics, Nara Medical University, Kashihara, Nara, Japan

1029

Effect of glycoPEGylation on Factor VIIa Binding and Internalization

Prosenjit Sen, Ph.D.¹^*, Samit Ghosh, Ph.D.¹^*, Pernille K Holm, Ph.D.²^*, Mirella Ezban, Ph.D.²^*, Usha Pendurthi, Ph.D.¹ and L. Vijaya Mohan Rao, Ph.D.¹

¹Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, TX
²Novo Nordisk, Maaloev, Denmark

1030

De-Immunization of Human Factor VIII: Identification of Epitopes in the C2 Domain

Leonard Moise, Ph.D¹^*, Jonathan Skupsky, BS²^*, Ryan Tassone¹^*, Julie A McMurry¹^*, William D Martin³^*, Anne S. De Groot, M.D.³^* and David W. Scott, PhD²

¹Research and Development, EpiVax, Inc., Providence, RI
²School of Medicine, University of Maryland, Baltimore, MD
³Research and Development, EpiVax, Inc., Providence

1031

Post-Transcriptional Regulation of Tissue Factor Expression in Human Monocytic Cells: Identification of Novel Exonic Splicing Enhancers for the Spliceosomal Protein SRp40 and Intronic Elements Critical for Exon 5 Definition

Sajiv Chandradas, BA¹^*, Jonathan G Tardos, MD¹^*, Ke Jiang, MSc²^* and Vladimir Bogdanov, PhD¹

¹Mount Sinai School of Medicine, New York, NY
²Neurology, Mount Sinai School of Medicine, New York, NY

1032

Alterations of P53 and PTEN Genes Are Associated with Increased TF Expression and Reduced Survival in Non Small Cell Lung Cancer

Sandra Regina, MD¹^*, Jean-Baptiste Valentin¹^*, S�bastien Lachot¹^*, Bruno Giraudeau, MD²^*, Jerome Rollin, PhD¹^* and Yves Gruel, MD¹

¹Dept. Hematology-Hemostasis, University Hospital of Tours, Tours, France
²Centre d'Investigation Clinique, University Hospital of Tours, Tours, France

1033

Moderate Pharmacological Platelet Count Reduction Limits Thrombus Formation without Hemostatic Impairment in Primates

Erik I Tucker¹^*, Ulla M Marzec²^*, Sawan Hurst¹^*, Andr�s Gruber, MD³ and Stephen R Hanson, PhD¹

¹Division of Biomedical Engineering, Oregon Health & Science University School of Medicine, Portland, OR
²Division of Biomedical Engineering, OHSU West Campus, Oregon National Primate Research Center, Beaverton, OR
³Division of Biomedical Engineering and Department of Medicine, Oregon Health and Science University School of Medicine

1034

Dual Effect of Platelet Factor Four on the Activities of Factor Xa

Martine Marie Fiore, PhD^* and Ian J Mackie, Reader, in, Haemostasis, and, Th^*

Haematology, University College London, London, United Kingdom

1035

Identification of a Factor IXa-Interactive Site within the C2 Domain of Factor VIIIa and a Crucial Role of These Associations for the Process of Clot Formation

Tetsuhiro Soeda^*, Keiji Nogami^*, Kenichi Ogiwara^*, Masahiro Takeyama^*, Katsumi Nishiya^* and Midori Shima

Department of Pediatrics, Nara Medical University, Kashihara, Nara, Japan

1036

Tissue Factor-Dependent Activation of Factor VIII by Factor VIIa in the Early Phase of Blood Coagulation

Tetsuhiro Soeda^*, Keiji Nogami^*, Tomoko Matsumoto^*, Kenichi Ogiwara^*, Katsumi Nishiya^* and Midori Shima

Department of Pediatrics, Nara Medical University, Kashihara, Nara, Japan

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^*signifies non-member of ASH

321.P1.67 Blood Coagulation and Fibrinolytic Factors Poster I