50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Coagulation Cofactors and Von Willebrand Factor

Monday, December 8, 2008: 3:30 PM-5:30 PM

3014-3016-3018 - West (Moscone Center)

Moderators:

Judith Lin, MD and Reinhard Schneppenheim, MD

3:30 PM

585

Platelet-Derived Factor Va Expressed on the Surface of the Activated Platelet Is GPI-Anchored

Jeremy P Wood¹^*, Ammon M. Fager¹^*, Jay R. Silveira¹^* and Paula B. Tracy, PhD²

¹Biochemistry, University of Vermont, Burlington, VT
²University of Vermont, Burlington, VT

3:45 PM

586

Evolutionary Adaptation of Factor V from the Venom of the Common Brown Snake into a Potent Procoagulant

Mettine H.A. Bos, Ph.D.¹, Michael Boltz¹^*, Liam St. Pierre, Ph.D.²^*, John de Jersey, Ph.D.³^*, Paul P Masci, Ph.D.³^*, Martin L Lavin, Ph.D.⁴^* and Rodney M. Camire, Ph.D.¹

¹Hematology, Children's Hospital of Philadelphia, Philadelphia, PA
²University of Queensland Centre for Clinical Research, Brisbane, Australia
³Faculty of Health Sciences, University of Queensland, Brisbane, Australia
⁴University of Queensland Centre for Clinical Research/QRxPharma Ltd, Brisbane/Sydney, Australia

4:00 PM

587

Factor VIII C1 Domain Residues 2092-2093 Participate in Membrane Binding

Henriet Meems¹^*, Alexander B Meijer¹^*, Dave Cullinan²^*, Koen Mertens, PhD¹ and Gary E. Gilbert²^*

¹Dept Plasma Proteins, Sanquin Blood Supply Foundation, Amsterdam, Netherlands
²VA Boston Healthcare System, Harvard Medical School, Boston, MA

4:15 PM

588

Intersection of Mechanisms of Type 2A Von Willebrand Disease through Defects in Von Willebrand Factor Multimerization, Secretion, ADAMTS-13 Susceptibility, and Regulated Storage

Paula M. Jacobi¹^*, Joan Cox Gill, MD², Kenneth D. Friedman, MD³, Robert R. Montgomery, MD⁴ and Sandra L. Haberichter, PhD⁵

¹Pediatrics, Medical College of Wisconsin, Milwaukee, WI
²Bleeding Disorders, Comprehensive Center for, Milwaukee, WI
³Blood Research Institute, Medical College of Wisconsin, TS Zimmerman Program for the Molecular and Clinical Biology of VWD, Milwaukee, WI
⁴TS Zimmerman Program for the Molecular and Clinical Biology of VWD, Blood Research Institute, Medical College of Wisconsin, Milwaukee, WI
⁵Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI

4:30 PM

589

Force Dependent Structural Changes of the Von Willebrand Factor A2 Domain Are Required for VWF Cleavage by ADAMTS13

Reinhard Schneppenheim, MD, PhD¹, Carsten Baldauf, PhD²^*, Tobias Obser¹^*, Ulrich Budde, MD³, Antje Pieconka³^*, Sonja Schneppenheim, MD³^* and Frauke Graeter, PhD²^*

¹Pediatric Hem. & Onc., University Med. Ctr., Hamburg-Eppendorf, Hamburg, Germany
²CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Shanghai, China
³Coagulation Laboratory, Aesculabor Hamburg, Hamburg, Germany

4:45 PM

590

Factor VIII and Platelets Cooperatively Accelerate Proteolytic Cleavage of Von Willebrand Factor by ADAMTS13 Under Shear Stress

Christopher G. Skipwith^*, Wenjing Cao^* and X. Long Zheng

Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA

5:00 PM

591

Suppression of the Immune Response to Human FVIII with FVIII Transgene Modified Tolerogenic Dendritic Cells in Hemophilic Mice

Rui-Jun Su, Ph.D^*, Angela Epp^*, Xiaoping Wu, Ph.D^* and Neil Josephson, MD

Research, Puget Sound Blood Center, Seattle, WA

5:15 PM

592

A Novel Role for Factor VIII and Other Coagulation Factors in Organ Size Control

Anna Aronovich¹^*, Dalit Tchorsh¹^*, Elias Shezen¹^*, Chava Rosen¹^*, Yael Klionsky¹^*, Sivan Cohen¹^*, Orna Tal¹^*, Uri Martinovich²^*, Helena Katchman¹^*, Smadar Eventov-Friedman¹^*, Ninette Amariglio, PhD³, Jasmine Jacob-Hirsch⁴^*, Gideon Rechavi, MD, PhD³^* and Yair Reisner¹

¹Immunology, Weizmann Institute of Science, Rehovot, Israel
²Israel National Hemophilia Center, Sheba Medical Center, Tel Hashomer, Israel
³Cancer Research Center, Sheba M.C., Tel-Hashomer, Israel
⁴Cancer Research Center, Sheba M.C., Tel-Hashomer, Israel, Ramat-Gan, Israel

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^*signifies non-member of ASH

321.O3.8 Coagulation Cofactors and Von Willebrand Factor