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321.O2.6 Novel Models of Hemorrhage, Thrombosis and Malignancy

Monday, December 8, 2008: 11:00 AM-12:30 PM
3014-3016-3018 - West (Moscone Center)
Moderators:
Sarah M Nordstrom and Pieter H. Reitsma
11:00 AM
391
Use of Multiphoton Intravital Imaging and a Multiscale Computational Model of Thrombus Development to Study the Role of FVII in Thrombogenesis

Malgorzata Kamocka, PhD1*, Zhiliang Xu, PhD2*, Nan Chen2*, Mark Alber2* and Elliot D. Rosen, PhD1*

1Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN
2Mathematics, Universiy of Notre Dame, Notre Dame, IN
11:15 AM
392
Increased Thrombosis in Vivo and Altered Coagulation in Vitro in STAT5AB-Deficient Mice

Sarah M Nordstrom*, Brandon C Sos*, Katelyn M Dow*, Tina S Fong*, Robert E Levy*, Jonathan Dukes* and Ethan J Weiss

Cardiovascular Research Institute, UCSF, San Francisco, CA
11:30 AM
393
A Novel Tissue Factor Resistance Locus on Mouse Chromosome 11 Confers Protection from Thrombosis through Reduced Activity of Factor XI

Katelyn M Dow1*, Sarah M Nordstrom1*, Brandon C Sos1*, Richard C Davis2*, Aldons J Lusis3* and Ethan J Weiss1

1Cardiovascular Research Institute, UCSF, San Francisco, CA
2Human Genetics, UCLA, Los Angeles, CA
3Medicine and Human Genetics, UCLA, Los Angeles, CA
11:45 AM
394
Loss of Clotting Function in Mice Expressing a Mutant Form of Fibrinogen Lacking the α Chain Thrombin Cleavage Site

Matthew Flick, PhD1, Joni M. Ullman2*, Joseph S. Palumbo, MD3, Eric S. Mullins, MD2, Keith W Kombrink3*, Kathryn E. Talmage2*, Maureen A. Shaw2*, Susan T. Lord, Professor, Ph.D.4*, Jay Degen2 and Oleg V Gorkun4*

1Children's Hospital Research Foundation and University of Cincinnati, Cincinnati, OH
2Pediatric Hem./Onc., Cincinnati Children's Hosp. and Med. Ctr., Cincinnati, OH
3Cincinnati Children's Hospital Medical Center and The University of Cincinnati College of Medicine, Cincinnati, OH
4Department of Pathology and Lab Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC
12:00 PM
395
Genetic Elimination of Prothrombin in Adult Mice Results in Fatal Spontaneous Hemorrhage in the Heart and Central Nervous System

Eric S. Mullins, MD1, Keith W. Kombrinck2*, Kathryn E. Talmage2*, Maureen A. Shaw1*, David P. Witte3*, Joni M. Ullman4*, Sandra J. Degen2*, William Sun2*, Matthew Flick, PhD5 and Jay Degen2

1Pediatric Hem./Onc., Cincinnati Children's Hosp. and Med. Ctr., Cincinnati, OH
2Developmental Biology, Cincinnati Children's Hosp. and Med. Ctr., Cincinnati, OH
3Pathology, Cincinnati Children's Hosp. and Med. Ctr., Cincinnati, OH
4Immunobiology, Cincinnati Children's Hosp. and Med. Ctr., Cincinnati, OH
5Children's Hospital Research Foundation and University of Cincinnati, Cincinnati, OH
12:15 PM
396
Thrombin Enhances Spontaneous Tumor Growth and Cell Cycle Activation by Downregulation of p27Kip1 and Upregulation of Skp2 and MiR-222

Liang Hu1*, Sherif Ibrahim2*, Cynthia Liu, Assistant, Professor, of, Pathol2*, Jeffrey Skaar3*, Michelle Pagano3* and Simon Karpatkin1

1Medicine/Hematology, NYU School of Medicine, New York, NY
2Pathology, New York University School of Medicine, New York, NY
3Pathology, NYU School of Medicine, New York, NY
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