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321.O1.6 Advances in the Study of APC and TFPI

Sunday, December 7, 2008: 4:30 PM-6:00 PM
3014-3016-3018 - West (Moscone Center)
Moderators:
David Green, MD, PhD and Susan A. Maroney
4:30 PM
Structural and Functional Studies to Define the Molecular Basis by Which Platelet Factor 4 (PF4) Increases Survival of Mice in Lipopolysaccharide (LPS)-Induced Endotoxicity

M. Anna Kowalska, PhD1, Karine Amirikian1*, Laurent O. Mosnier, PhD2, Hartmut Weiler, PhD3, Sriram Krishnaswamy, PhD1 and Mortimer Poncz, MD1

1The Children's Hospital of Philadelphia, Philadelphia, PA
2Molecular & Experimental Medicine, The Scripps Research Institute, La Jolla, CA
3Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI

4:45 PM
Platelet Factor 4 Mediates Activated Protein C Resistance by Impairment of Protein S Cofactor Enhancement

Roger JS Preston, PhD1*, Jennifer A Johnson, BSc1*, Fionnuala Ni Ainle, MD1*, Shona Harmon, PhD1*, Owen P. Smith, MD2*, Barry White, MD3* and James S O'Donnell, MD, PhD3

1Haemostasis Research Group, Trinity College Dublin, Dublin, Ireland
2Our Lady's Children's Hospital, Crumlin, Dublin, Ireland
3National Centre for Coagulation Disorders, Dublin, Ireland

5:00 PM
Dissociation of Activated Protein C Functions by Elimination of Protein S Cofactor Enhancement

Roger JS Preston, PhD1*, Shona Harmon, PhD1*, Fionnuala B Ni Ainle, MD1*, Jennifer A Johnson, BSc1*, Moya Cunningham, MD1*, O. Smith2*, Barry White, MD3* and James S O'Donnell, MD, PhD3

1Haemostasis Research Group, Trinity College Dublin, Dublin, Ireland
2Our Lady's Children's Hospital, Crumlin, Dublin, Ireland
3National Centre for Coagulation Disorders, Dublin, Ireland

5:15 PM
Enhancement of the Anticoagulant Properties of Protamine Sulphate by Activated Protein C

Fionnuala Ni Ainle, MD1*, Roger JS Preston, PhD1*, Vince P Jenkins, PhD1*, Jennifer A Johnson, BSc1*, Shona Harmon, PhD1*, O. Smith2*, Barry White, MD3* and James S O'Donnell, MD, PhD3

1Haemostasis Research Group, Trinity College Dublin, Dublin, Ireland
2Our Lady's Children's Hospital, Crumlin, Dublin, Ireland
3National Centre for Coagulation Disorders, Dublin, Ireland

5:30 PM
Expression of Tissue Factor Pathway Inhibitor (TFPI) by Brain Endothelium

Susan A. Maroney, Josephine P. Ferrel* and Alan E. Mast

Blood Center of Wisconsin, Milwaukee, WI

5:45 PM
Engineering Kunitz Domain of Human Tissue Factor Pathway Inhibitor-2 to Selectively Inhibit Fibrinolysis: An Antifibrinolytic Agent with Potential to Replace Aprotinin

Madhu S Bajaj1*, Godwin I Ogueli2*, Amy E Schmidt2*, Sreejesh Shanker2* and S. Paul Bajaj3

1Pulmonology & Critical Care, UCLA, Los Angeles, CA
2Orthopaedic Surgery, UCLA/Orthopaedic Hospital, Los Angeles, CA
3UCLA/Orthopedic Hospital, Los Angeles, CA

*signifies non-member of ASH