50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Disorders of Platelet Number or Function Poster I

Saturday, December 6, 2008: 5:30 PM-7:30 PM

Hall A (Moscone Center)

Antiplatelet Antibodies in WASP(-) Mice Correlate with Accelerated in Vivo Platelet Consumption Rates

Bindumadhav M Marathe¹^*, Amanda Prislovsky²^*, Amira Hosni²^* and Ted S Strom, MD, PhD²

¹Pathology and Laboratory Medicine, University of Tennessee Health Sciences Center, Memphis, TN
²Pathology and Laboratory Medicine, Memphis VA Medical Center, Memphis, TN

1231

Mice Lacking Wasp-Interacting Protein Evolve Anti-Platelet IgAs That Impair Platelet Responses Mediated by the Collagen Receptor GPVI

Hervé Falet, PhD¹, Michael P. Marchetti¹^*, Delphine Simon¹^*, Raif S. Geha, MD²^* and John H. Hartwig, PhD¹^*

¹Division of Translational Medicine, Brigham and Women's Hospital, Boston, MA
²Division of Immunology, Children's Hospital Boston, Boston, MA

1232

Recombinant PDGF-BB Enhances Platelet Recovery in Mice with Radiation Induced Thromobocytopenia

Jie Yu Ye¹^*, Godfrey ChiFung Chan, MD², Shing Chan¹^*, Jue Cong Luo¹^* and Mo Yang¹^*

¹Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China
²Queen Mary Hospital, Hong Kong, Hong Kong

1233

Heterozygous Ala156Val Mutation in the GPIb Alpha (Heterozygous Bernard-Soulier Syndrome Type Bolzano) Induces Macrothrombocytopenia by Hampering Proplatelet Formation

Alessandra Balduini¹, Alessandro Malara¹^*, Stefania Badalucco¹^*, Valeria Bozzi²^*, Isabella Pallotta¹^*, Patrizia Noris²^*, Mauro Torti¹, Carlo L Balduini²^* and Alessandro Pecci²^*

¹Department of Biochemistry, University of Pavia, Pavia, Italy
²Department of Internal Medicine, University of Pavia, IRCCS San Matteo Foundation, Pavia, Italy

1234

Platelets Having a W127X Mutation in GPIX Express Sufficient Residual Amounts of the GPIbα Chain to Support Ristocetin-Mediated Agglutination and Adhesion to VWF and Collagen Under Conditions of Flow

Taisuke Kanaji¹^*, Yuka Takata¹^*, Masaaki Moroi²^*, Ritsuko Seki¹^*, Eijiro Oku¹^*, Masayuki Sano³^*, Sachie Nakazato⁴^*, Kenji Izuhara⁵^*, Eizaburo Sueoka⁶^*, Yutaka Imamura⁷^* and Takashi Okamura, MD, PhD¹

¹Division of Hematology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan
²Department of protein Biochemistry, Institute of Life Science, Kurume University, Kurume, Japan
³Department of Internal Medicine, Maeda Hospital, Saga, Japan
⁴Department of Laboratory Investigation, Faculty of Medicine, Saga University, Saga, Japan
⁵Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga, Japan
⁶Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan
⁷Division of Haematology, Department of Internal Medicine, St Maria Hospital, Kurume, Japan

1235

Apoptotic-Like Events in Bernard-Soulier Syndrome (BSS) Platelets

Margaret L. Rand¹, Hong Wang¹^*, K.W. Annie Bang²^*, Jerome M. Teitel³, Victor S. Blanchette¹, Alan T. Nurden⁴ and John Freedman²

¹Haematology, The Hospital for Sick Children, Toronto, ON, Canada
²Transfusion Medicine, St. Michael's Hospital, Toronto, ON, Canada
³Hematology, St. Michael's Hospital, Toronto, ON, Canada
⁴CRPP/PTIB, Hôpital Xavier Arnozan, Pessac, France

1236

Glanzmann’s Thrombasthenia Patients with No Mutations in Both the ITGA2B and ITGB3 Genes as Identified by Conformation Sensitive Gel Electrophoresis (CSGE)

Meganathan Kannan, PhD¹^*, Firdos Ahmad, M, Sc¹^*, Birendra K Yadav, M, Sc¹^*, Rajive Kumar, MD²^*, Jawed Fareed, Ph.D.³ and Renu Saxena, MD¹^*

¹Department of Hematology, All India Institute of Medical Sciences, New Delhi, India
²Medical Oncology, IRCH, All India Institute of Medical Sciences, New Delhi, India
³Pathology and Pharmacology, Loyola University Medical Center, Maywood, IL

1237

Screening Tool for Bleeding Disorders in Women with Menorrhagia: Evaluation in a Prospective US Multi-Site Cohort

Claire S. Philipp¹, Ambarina Faiz¹^*, Vanessa Byams²^*, Connie H. Miller²^*, John A. Heit³, Peter A. Kouides⁴, Roshni Kulkarni⁵, Andrea Lukes⁶^* and Sidney F. Stein⁷

¹UMDNJ - Robert Wood Johnson Medical School, New Brunswick, NJ
²Centers for Disease Control and Prevention, Atlanta, GA
³Mayo Clinic, Rochester, MN
⁴Rochester General Hosp, Rochester, NY
⁵Michigan State University, East Lansing, MI
⁶Duke University, Durham, NC
⁷Emory School of Medicine, Atlanta, GA

1238

Morphological Changes of Platelets from Patients with Von Willebrand Disease Types 2B and 3 Suggest That Von Willebrand Factor Intervenes in Platelet Formation from Megakaryocytes

Paquita Nurden¹, Alan T Nurden¹^*, Jean-Max Pasquet²^*, Jocelyne Enouf³^*, Cécile Faurie-Bonnafous¹^*, Sylvia La Marca⁴^*, Margherita Punzo⁴^*, Luciano Baronciani⁴^* and Augusto B. Federici⁴

¹Centre de Référence des Pathologies Plaquettaires, Pessac, France
²Université de Bordeaux2, INSERM U878, Bordeaux, France
³Hôpital Lariboisière, INSERM U689, Paris, France
⁴Dept. of Internal Medicine, University of Milan, Milano, Italy

1239

The Association Between SHP-2 Mutations and Platelet Function in Noonan Syndrome

Jayson M. Stoffman, MD, FRCP(C)¹, Archibald McNicol, PhD²^*, Teresa Zelinski, PhD³^*, Bernard N. Chodirker Sr., MD, FRCP(C), FCCMG¹^* and Sara J. Israels, MD⁴

¹Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada
²Oral Biology, University of Manitoba
³Pediatrics and Child Health, University of Manitoba
⁴Pediatrics and Child Health and the Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, MB, Canada

1240

Angelica Polysaccharides Promotes Thrombopoiesis through the Phosphatidylinositol 3-Kinase/Akt Pathway

Mo Yang¹^*, Godfrey ChiFung Chan, MD², Jie Yu Ye¹^* and Chang Liu³^*

¹Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China
²Queen Mary Hospital, Hong Kong, Hong Kong
³Molecular Chinese Medicine Laboratory, The University of Hong Kong, Hong Kong, China

1241

The Effect and Underlying Mechanism of Melatonin on Platelet Formation and Survival in a Thrombocytopenic Model

Mo Yang¹^*, Min Zhou²^*, Jie Yu Ye¹^*, Yiu Fai Cheung¹^*, Shing Chan¹^*, Shau Yin Ha¹ and Godfrey ChiFung Chan, MD³

¹Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China
²Department of Hematology, Chengdu Childre's Hospital, Chengdu, China
³Queen Mary Hospital, Hong Kong, Hong Kong

1242

Neurocardiogenic Syncope Patients Often Have Platelet Delta Granule Storage Pool Deficiency and Decreased Platelet Serotonin Levels

Karin Chang, BA¹^*, Cole A Bennett, BS²^*, Kathryn Boehm, MD³^* and William T. Gunning, PhD⁴

¹Department of Pathology, University of Toledo College of Medicine, Toledo, OH
²University of Toledo College of Medicine, Toledo, OH
³Adolesent and Young Adult Health Services, Toledo, OH
⁴Department of Pathology, College of Medicine, Toledo, OH

1243

A Myelodysplastic Syndrome Associated with a Clonal GATA1 Mutation

Kathleen Freson¹^*, Liesbeth De Waele¹^*, Chantal Thys²^*, Christine Wittevrongel³^*, Peter Vandenberghe⁴^*, Rita De Vos⁵^*, Paresh Vyas⁶^* and Christel Van Geet⁷

¹Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium
²center for Molecular and Vascular Biology, university of Leuven, Leuven, Belgium
³Center for Molecular and Vascular Biology, university of Leuven, Leuven, Belgium
⁴Center for Human Genetics, University of Leuven, Leuven, Belgium
⁵department of Pathology, university of Leuven, Leuven, Belgium
⁶Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
⁷Center for Molecular and Vascular Biology & Department of Pediatrics, University of Leuven, Leuven, Belgium

1244

The Use of the Pre-Test Clinical Score (4T's) Alone Does Not Detect All Diagnoses of Heparin-Induced Thrombocytopenia in the Critically Ill

Kirsty M Cuthill, MBBS, MRCP¹^*, Andrew Retter, MBBS, MRCP¹, David A Gurney¹^* and Gary W Moore²^*

¹Haematology, Guy's and St. Thomas' NHS Trust, London, United Kingdom
²Centre for Haemostasis & Thrombosis, Guy's and St. Thomas' NHS FoundationTrust, London, United Kingdom

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^*signifies non-member of ASH

311.P1.66 Disorders of Platelet Number or Function Poster I