50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Inherited and Acquired Platelet Disorders

Sunday, December 7, 2008: 4:30 PM-6:00 PM

120-121-122-123-124-125 - North (Moscone Center)

Moderators:

A. Koneti Rao, MD and Catherine PM Hayward, MD, PhD

4:30 PM

Recombinant Human HPA-1A Antibodies for Treatment of Fetomaternal Alloimmune Thrombocytopenia (FMAIT) : Proof of Principle in An in Vivo Murine Model and Human Volunteer Studies

Cedric Ghevaert¹^*, David A. Wilcox, PhD², Juan Fang²^*, Kathryn Armour³^*, Mike R Clark³^*, Willem H. Ouwehand¹^* and Lorna M Williamson¹^*

¹NHS Blood and Transplant, Cambridge, United Kingdom
²Medical College of Wisconsin, Milwaukee, WI
³Pathology Department, University of Cambridge, Cambridge, United Kingdom

4:45 PM

A Common Single Nucleotide Polymorphism in the Chromosome 7q22.3 Region, Which Is Frequently Deleted in Myeloid Malignancies, Is Associated with Mean Platelet Volume and Platelet Function in Healthy Individuals

Nicole Soranzo¹^*, Marloes R. Tijssen²^*, Augusto Rendon²^*, Christine Meisinger³^*, Chris I. Jones⁴^*, Christian Gieger³^*, Nicholas A. Watkins²^*, Stephan Menzel⁵^*, Holger Prokisch³^*, Jonathan Stephens²^*, Angela Doering³^*, Wendy N. Erber², Simon C. Potter¹^*, Philippa Burns²^*, Jennifer Jolley²^*, Mario Falchi⁶^*, Stephen F. Garner²^*, Angela Rankin²^*, Swee Lay Thein⁵, H-Erich Wichmann⁷^*, Alison H. Goodall⁸^*, Thomas Illig³^*, Tim D. Spector⁵^*, Panos Deloukas¹^* and Willem H. Ouwehand²^*

¹Wellcome Trust Sanger Institute, Hinxton, United Kingdom
²Haematology, University of Cambridge & NHS Blood and Transplant, Cambridge, United Kingdom
³German Research Center for Environmental Health, Neuherberg, Germany
⁴University of Reading, Reading, United Kingdom
⁵Kings College London, London, United Kingdom
⁶Genomic Medicine, Imperial College, London, United Kingdom
⁷Ludwig-Maximilians-Universitat, Munich, Germany
⁸Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom

5:00 PM

Bortezomib Induces Thrombocytopenia by Inhibiting Proplatelet Formation but Not Proliferation and Endomitosis in Human Primary Megakaryocytes

Wataru Nogami^*, Akiko Yamane^*, Takanori Nakamura^*, Eri Matsuki^*, Yasuo Ikeda^* and Yoshitaka Miyakawa

Division of Hematology, Keio University, Tokyo, Japan

5:15 PM

Absent Collagen-Induced Platelet Activation in a Patient Double Heterozygous for Two GPVI Mutations

Martine Jandrot-Perrus¹^*, Bénédicte Dumont¹^*, Dominique Lasne²^*, Chantal Rothschild³^*, Bernard Grandchamp⁴^* and Nadine Ajzenberg⁵^*

¹U698, INSERM, Paris, France
²Laboratoire d'Hématologie, Hôpital Necker, Paris, France
³Centre de Traitement des Hémophiles, Hôpital Necker, Paris, France
⁴Biochimie B, AP-HP, Hôpital Bichat, Paris, France
⁵Laboratoire d'Hématologie, AP-HP, Hôpital Bichat, Paris, France

5:30 PM

Rare Polymorphisms Associated with Neonatal Alloimmune Thrombocytopenia (NATP) and New Mutations Identified in Platelet Glycoproteins (GP)

Julie A. Peterson, PhD¹, Maria Gitter¹^*, Adam Kanack¹^*, Brian Curtis²^*, Janice McFarland²^* and Richard H. Aster, MD¹

¹The Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI
²BloodCenter of Wisconsin, Milwaukee, WI

5:45 PM

Clinical Phenotype and Long Term Outcome in a Large Cohort of X-Linked Thrombocytopenia (XLT)/Mild Wiskott-Aldrich-Syndrome Patients

Michael H Albert, MD¹^*, Tanja Bittner¹^*, Daniel Stachel, MD², Shigeaki Nonoyama³^*, Lucia Notarangelo⁴^*, Siobhan Burns⁵^*, Isabelle Pellier⁶^*, Gabriele Strauss⁷^*, Tomohiro Morio⁸^*, Kohsuke Imai³^*, Teresa Espanol⁹^*, Benjamin Gathmann¹⁰^*, Manfred Hönig¹¹^*, Jeroen G Noordzij¹²^*, Michaela Nathrath¹³^*, Alfons Meindl¹³^*, Uwe Wintergerst¹^*, Alain Fischer¹⁴^*, Adrian Thrasher, MD, PhD¹⁵^*, Bernd H Belohradsky¹^* and Hans D Ochs¹⁶^*

¹Pediatric Infection/Immunity and Hematology/Oncology, Dr. von Haunersches Kinderspital, Munich, Germany
²BMT Ward, Children's Hosp. of the Univ. of Erlangen, Erlangen, Germany
³National Defense Medical College, Saitama, Japan
⁴Children's Hospital, Brescia, Italy
⁵Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
⁶Unité Immuno-Hémato-Oncologie Pédiatrique, CHU Angers, Angers, France
⁷Charité Campus Virchow Klinikum, Berlin, Germany
⁸Tokyo Medical and Dental University Hospital, Tokyo, Japan
⁹C.S.I. Universitaria, Barcelona, Spain
¹⁰University Medical Center, Freiburg, Germany
¹¹University Clinic for Child and Adolescent Medicine, Ulm, Germany
¹²University Medical Center, Nijmegen, Netherlands
¹³Technische Universität München and HelmholtzZentrum, Munich, Germany
¹⁴Inserm, Paris, France
¹⁵Molecular Immunology Unit, Institute of Child Health, London, ARRAY(0xc4f13bc)
¹⁶Children's Hospital, Seattle, WA

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^*signifies non-member of ASH

311.O1.6 Inherited and Acquired Platelet Disorders