50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Vascular Wall Biology, Endothelial Progenitor Cells, and Platelet Adhesion Poster I

Saturday, December 6, 2008: 5:30 PM-7:30 PM

Hall A (Moscone Center)

Making Functional Endothelial Progenitors: Humanized Large-Scale Animal Serum-Free Propagated Adult Blood-Derived Endothelial Colony-Forming Cells Assemble Stable Perfused Vessels in Vivo

Andreas Reinisch¹^*, Nicole A Hofmann²^*, Anna C Obenauf³^*, Karl Kashofer⁴^*, Eva Rohde²^*, Katharina Schallmoser²^*, Daniela Thaler¹^*, Margareta Frühwirth¹^*, Werner Linkesch⁵^*, Michael R Speicher³^* and Dirk Strunk¹

¹Department of Hematology & Stem Cell Transplantation, Stem Cell Research Unit Graz, Medical University of Graz, Graz, Austria
²Stem Cell Research Unit Graz, Medical University of Graz, Graz, Austria
³Institute of Human Genetics, Medical University of Graz, Graz, Austria
⁴Institute of Pathology, Medical University of Graz,, Graz, Austria
⁵Department of Hematology & Stem Cell Transplantation, Medical University of Graz, Graz, Austria

1883

Human Endothelial Progenitor Cells: A Novel and Promising Cellular Therapy for Regenerating Intestinal Mucosa

Josh A. Wood¹^*, Evan Colletti¹^*, Laura E. Mead²^*, David A. Ingram Jr., MD³^*, Christopher D Porada, PhD¹^*, Esmail Zanjani¹, Mervin C. Yoder, MD² and Graca Almeida-Porada, MD, PhD¹

¹Animal Biotechnology, University of Nevada, Reno, Reno, NV
²Cancer Research Institute, Wells Ctr. for Pediatric Rsch., Indianapolis, IN
³Cancer Research Institute, Indiana Univ. School of Med., Indianapolis, IN

1884

A Role for Activation of the Kallikrein-Kinin System in the Homing Property of Endothelial Progenitor Cells

Yi Wu, PhD^*, Christina Hu^* and Robert W. Colman, MD

The Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA

1885

Taxanes Induce a Rapid Mobilization of Different Populations of Circulating Endothelial Progenitors by SDF-1 Modulation in Cancer Patients

Anna Bono¹^*, Jessica Quarna¹^*, Paola Marighetti¹^*, Angelica Calleri²^*, Pierluigi Antoniotti¹^*, Patrizia Mancuso²^*, Emile E Voest³^*, Marlies Langenberg³^*, Jeanine Roodhart³^*, Yuval Shaked⁴^*, Robert S Kerbel⁴^* and Francesco Bertolini¹

¹European Institute of Oncology, Milan, Italy
²Hematology, European Institute of Oncology, Milan, Italy
³University of Utrecht, Utrecht, Netherlands
⁴Sunnybrook Health Sciences Center, University of Toronto, Toronto, ON, Canada

1886

Endothelial Cell Elongation Impacts Thrombogenicity Independent of Fluid Shear Stress

Keri B Vartanian¹^*, Brad J Blakley¹^*, Owen JT McCarty, PhD²^*, Stephen Hanson, PhD³ and Monica T Hinds, PhD¹^*

¹Biomedical Engineering, Oregon Health & Science University, Portland, OR
²Division of Biomedical Engineering, Oregon Health and Science University School of Medicine, Portland, OR
³OR Health & Science Univ., Portland, OR

1887

Cholesterol Promotes Acute Leukemia Progression through Systemic but Selective Endothelial Cell Activation

Tania Carvalho¹^*, Rita Fragoso¹^*, Ana L Gomes¹^*, Cristina Casalou¹^*, Leila Martins²^*, Joao Barata²^* and Sergio Dias¹

¹Angiogenesis Lab, CIPM, Portuguese Institute of Oncology, Lisbon, Portugal
²Unidade de Biologia Tumoral, Instituto de Medicina Molecular, Lisbon, Portugal

1888

Thrombin Inhibits NF-κb and RhoA Pathways in Cytokine-Stimulated Vascular Endothelial Cells When EPCR Is Occupied by Protein C

Alireza R. Rezaie, PhD and Jong-Sup Bae^*

Biochemistry and Molecular Biology, St. Louis Univ. School of Med., Saint Louis, MO

1889

Endothelial Dysfunction and Paradoxical Resistance to Thrombosis in a Transgenic Mouse Model of Severe Hyperhomocysteinemia

Sanjana Dayal¹^*, Melissa J Jensen¹^*, Frank M Faraci²^*, Warren D Kruger³^* and Steven R. Lentz⁴

¹Internal Medicine, University of Iowa, Iowa City, IA
²Internal Medicine and Pharmacology, University of Iowa, Iowa City, IA
³Fox Chase Cancer Research Center, Philadelphia, PA
⁴University of Iowa, Iowa City, IA

1890

Bortezomib Improves Endothelial Thromboresistance Via Induction of KLF Transcription Factors

Toyoko Hiroi¹^*, Clayton B Deming¹^*, Haige Zhao¹^*, Baranda S Hansen¹^*, Elisabeth K Arkenbout¹^*, Thomas J Myers²^*, William J Riordan²^*, Michael A McDevitt, Assistant, Professor¹ and Jeffrey J Rade¹^*

¹Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
²Millennium Pharmaceuticals, Inc., Cambridge, MA

1891

Evidence of Endothelial Dysfunction in Cocaine Users

Jaime Pereira, MD¹, Claudia G. Sáez, PhD¹^*, Julio Pallavicini, MD²^*, Paulina Olivares¹^*, Olga Panes¹^*, Natalia Moreno¹^*, Sabine Belmont¹^*, Teresa Massardo, MD³^* and Diego Mezzano, MD¹

¹Hematology-Oncology, School of Medicine, P. Universidad Católica de Chile, Santiago, Chile
²Clinica Siquiatrica, Hospital Clinico, Universidad de Chile, Santiago, Chile
³Medicina Nuclear, Hospital Clinico, Universidad de Chile, Santiago, Chile

1892

Activation of Endothelial Cells by Cocaine

William Hobbs, MD, PhD¹, Junmei Chen, PhD² and Jose A. Lopez, MD³

¹Hematology, University of Washington, Seattle, WA
²Research, Puget Sound Blood Ctr., Seattle, WA
³Puget Sound Blood Center, Seattle, WA

1893

Immunomodulatory Drugs (Thalidomide and Lenalidomide) Up-Regulate Endothelial Tissue Factor in Vitro Resulting in An Acquired Hypercoagulable State

Serena Valsami, MD¹^*, Maria Sybille Leikauf¹^*, Jerzy Madon, MD¹^*, Wolfram Ruf, MD² and Lars M Asmis, MD¹

¹Department of Medicine, Division of Hematology, University Hospital of Zurich, CH 8091 Zurich, Switzerland
²SP258, The Scripps Research Institute, La Jolla, CA

1894

Purified Gr1+CD11b+ Cells Induce Neovascularization in An Ischemic Hind Limb Mouse Model

Jeong A Kim, MD, PhD¹^*, Keith March, MD, PhD²^*, Heedon Chae, PhD¹^*, Brian Johnstone, PhD²^*, Todd Cook, BSc²^*, Stephanie Merfeld-Clauss, BSc²^* and Hal E. Broxmeyer, PhD¹

¹Department microbiology and immunology and Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN
²Indiana Center of Vascular Biology and Medicine, Indiana University School of Medicine, Indianapolis, IN

1895

Vascular Branching Morphogenesis of the Placenta Requires Expression of Ott1(Rbm15) in the Trophoblast Compartment

Glen D. Raffel, MD, PhD¹, Gerry C Chu²^*, Dana E. Cullen³^*, Roderick T Bronson, DVM⁴^*, Olivier A Bernard⁵^* and D. Gary Gilliland⁶

¹Harvard Medical School, Brigham & Women's Hospital, Boston, MA
²Medical Oncology, Dana Farber Cancer Institute, Boston, MA
³Department of Medicine, Division of Hematology, Brigham and Women's Hospital; Dana-Farber Cancer Institute; Harvard Medical School, Boston, MA
⁴Department of Rodent Pathology, Harvard Medical School, Boston, MA
⁵Hôpital Necker-Enfants Malades, Laboratoire d'Hématologie, Paris, France
⁶Brigham and Women's Hospital, Boston, MA

1896

A Novel Method for Screening Anti-Angiogenic Compounds: The Chorionicallantoic Membrane (CAM)/Feather Bud (FB) Assay

Haiming Chen, MD, PhD¹^*, Cathy S Wang¹^*, Mingjie Li¹^*, Eric Sanchez¹^*, Jennifer Li¹^*, Ariana M Berenson¹^*, Jeffrey A Steinberg¹^*, Hang Chen¹^*, Jing Shen¹^*, Zhi-Wei Li, PhD¹, Benjamin Bonavida, PhD² and James R. Berenson, MD¹

¹Hematology/Oncology, Institute for Myeloma & Bone Cancer Research, West Hollywood, CA
²Microbiology, Immunology & Molecular Genetics, University of CA, Los Angeles, Los Angeles, CA

1898

Placenta Endothelial Protein 1 Is a Novel Neural Guidance Molecule on Angiogenesis

Chieh-Huei Wang¹^*, Chia-Yi Lin²^*, Chung-Chi Yang³^* and Yung-Jen Chuang, PhD²

¹Dept. of Life Science, Inst. of Bioinformatics & Structural Biology, Hsinchu, Taiwan
²Dept. of Life Science, Inst. of Bioinformatics & Structural Biology, Hsinchu, Taiwan, Taiwan
³Division of Cardiology, Department of Medicine, Tao-Yuan Armed Forces General Hospital

1899

Cell-Driven Angiogenesis and Neurogenesis after Stroke Is Regulated by Platelet's Microparticles

David Varon¹, Yael Haion²^*, Alexander Brill¹^* and Ronen Leker²^*

¹Hematology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
²Neurology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

1900

Contribution of Intrinsic and Extrinsic Coagulation Pathways to Thrombus Formation in the Mouse Carotid Artery

Antonella Zampolli, PhD¹^*, Patrizia Marchese, PhD¹^*, Wolfram Ruf, MD², Nigel Mackman, PhD³ and Zaverio M. Ruggeri, MD¹

¹Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA
²Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, CA
³University of North Carolina at Chapel Hill, Chapel Hill, NC

1901

CD36 Mediated Reactive Oxygen Species Formation Contributes to Thrombosis

Wei Li, MD, PhD¹^*, Maria Febbraio¹^* and Roy L. Silverstein, MD²

¹Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH
²Lerner Rsch. Inst.-NC10, Cleveland Clinic Foundation, Cleveland, OH

1902

Heme Induces Endothelial Tissue Factor Expression: Potential Role in Hemostatic Activation in Patients with Intravascular Hemolysis Including Sickle Cell Disease

Yamaja Setty, PhD¹, Suhita Gayen Betal¹^*, Jie Zhang¹^*, Nigel S Key²^* and Marie Stuart¹^*

¹Pediatrics, Thomas Jefferson University, Philadelphia, PA
²Medicine, University of North Carolina, Chapel Hill, NC

1903

A Diet Rich in Alpha-Linolenic Acid Diminishes Atherosclerosis in Apolipoprotein E-Deficient Mice and Reduces Arachidonic Acid in Red Cell Membranes

Christian M.R. Matter¹^*, Christine Lohmann²^*, Eva Richter³^*, Florian Leiber³^*, Thomas F. Lüscher²^* and Juerg H. Beer, MD⁴

¹Cardiovascular Research, Institute of Physiology and and Zurich Center of Integrative Human Physiology, University of Zurich and Cardiology, University Hospital of Zurich, Zurich, Switzerland
²Cardiovascular Research, Institute of Physiology, University of Zurich and Cardiology, University Hospital of Zurich, Zurich, Switzerland
³Institute for Animal Science, Federal Institute of Technology Zurich, Zurich, Switzerland
⁴Kantonsspital Baden, Baden, Switzerland

1904

Reversibility in Mice of FXI Antisense-Induced Anticoagulation by Administration of FXI Protein Concentrate or a Sense Oligonucleotide

Chenguang Zhao¹^*, Brett P. Monia, PhD¹, Andy Siwkowski¹^*, Jeff Crosby²^* and Hong Zhang²^*

¹Antisense Drug Discovery, Isis Pharmaceuticals, Inc., Carlsbad, CA
²Isis Pharma., Inc., Carlsbad, CA

1905

Combating Cardiovascular Disease: Is There a Risk of Foam Cell Formation in Transplanted Angiocompetent Cells Compromising Intended Beneficial Effects of Vascular Regenerative Therapy?

Eva Rohde¹^*, Elma Aflaki²^*, Eleonore Froehlich³^*, Gerhard Lanzer⁴^*, Dagmar Kratky²^* and Dirk Strunk¹

¹Stem Cell Research Unit Graz, Medical University of Graz, Graz, Austria
²Institute of Molecular Biology & Biochemistry, Medical University of Graz, Graz, Austria
³Medical Research Center, Medical University of Graz, Graz, Austria
⁴University Clinic for Blood Group Serology and Transfusion Medicine, Medical University of Graz, Graz, Austria

1906

HIF1 Induced Glutathione Dysregulation in Platelets Associated with Increased Risk of Vascular Disease in Chuvash Polycythemia

Heather Gilbert*, MD¹^*, Donghoon Yoon*, PhD²^*, Adelina I Sergueeva³^*, Victor R. Gordeuk, MD⁴ and Josef T. Prchal, MD⁵

¹Huntsman Cancer Institute, Salt Lake Cty, UT
²Medicine, Hematology Div., University of Utah, Salt Lake City, UT
³Cheboksary Children's hospital, Cheboksary, Russia
⁴Howard University, Washington, DC
⁵University of Utah, Salt Lake City, UT

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^*signifies non-member of ASH

302.P1.50 Vascular Wall Biology, Endothelial Progenitor Cells, and Platelet Adhesion Poster I