50th ASH Annual Meeting and Exposition (December 6

Monday, December 8, 2008: 7:00 AM-9:00 AM

2002-2004 - West (Moscone Center)

Moderators:

Denisa D. Wagner, Ph.D and Barry S. Coller, MD

7:00 AM

Platelets Lacking Both Pleckstrin and Pleckstrin-2 Have a Marked Deficient Cell Spreading and Actin Assembly

Yanfeng Wang, M.D.¹^*, Lurong Lian, M.D.¹^*, John H. Hartwig, PhD² and Charles S. Abrams, MD³

¹University of Pennsylvania School of Medicine, Philadelphia, PA
²Brigham & Women's Hospital, Boston, MA
³School of Medicine, University of Pennsylvania, Philadelphia, PA

7:15 AM

254

Measurement of the Lifetime of Bonds Between αIIbβ3 and Fibrinogen Using Constant Unbinding Forces Generated by Optical Tweezers

Rustem I. Litvinov¹^*, Henry Shuman²^*, John Weisel¹^* and Joel S. Bennett³^*

¹Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA
²Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA
³Department of Medicine/Hematology-Oncology Division, University of Pennsylvania School of Medicine, Philadelphia, PA

7:30 AM

255

Limiting αIIb Extension at the Genu Differentially Affects Binding of Small and Large Ligands to αIIbβ3

Robert Blue¹^*, Jonathan Steinberger, MD¹^*, Jihong Li, MD¹^*, Marta Murcia, PhD²^*, Marta Filizola²^* and Barry S. Coller, MD¹

¹Laboratory of Blood and Vascular Biology, The Rockefeller University, New York, NY
²Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, NY

7:45 AM

256

Structural and Therapeutic Insights from the Species Specificity and in Vivo Antithrombotic Activity of a Novel αIIb-Specific αIIbβ3 Antagonist

Robert Blue¹^*, M. Anna Kowalska, PhD², Marta Murcia, PhD³^*, Christin A. Janczak¹^*, Marketa Jirouskova, PhD¹^*, Jihong Li, MD¹^*, Amanda Harrington¹^*, Rudy Fuentes²^*, Michael A. Thornton, PhD⁴^*, Marta Filizola³^*, Mortimer Poncz, MD²^* and Barry S. Coller, MD¹

¹Laboratory of Blood and Vascular Biology, The Rockefeller University, New York, NY
²Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA
³Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, NY
⁴Department of Biology, Florida A&M University, Tallahassee, FL

8:00 AM

257

Crystal Structure of Von Willebrand Factor (VWF) A1 Domain in Complex with Aptamer ARC1172, An Inhibitor of VWF-Platelet Binding

Ren-Huai Huang, PhD¹^*, David Fremont, PhD²^*, Elodee A Tuley¹^*, John L Diener, PhD³^*, Robert G Schaub, PhD⁴^* and J. Evan Sadler, MD, PhD¹

¹Department of Medicine, Washington University School of Medicine, Saint Louis, MO
²Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO
³Novartis Institutes for BioMedical Research, Inc, Cambridge, MA
⁴Archemix Corp., Cambridge, MA

8:15 AM

258

Binding of ADAMTS13 to Von Willebrand Factor Under Static Conditions and Under Fluid Shear Stress

Hendrik B Feys, PhD¹^*, Patricia J Anderson, PhD¹^* and J. Evan Sadler, MD, PhD²

¹Department of Medicine, Washington University in Saint Louis Medical School, Saint Louis, MO
²Department of Medicine, Washington University Medical School, Saint Louis, MO

8:30 AM

259

VWF-Cleaving Protease ADAMTS13 Reduces Brain Injury Following Ischemic Stroke in Mice: Essential Role for VWF in Stroke

Bing-Qiao Zhao¹^*, Anil kumar Chauhan, PhD¹, Ian S. Patten¹^*, Michael Dockal, PhD²^*, Friedrich Scheiflinger³ and Denisa D. Wagner, Ph.D¹^*

¹Department of Pathology, Harvard Medical school, Immune Disease Institute, Boston, MA
²Protein Engineering, Baxter Bioscience, Orth/Donau, Austria
³Discovery Research, Baxter Innovations GmbH, Vienna, Austria

8:45 AM

260

ADAMTS13 Gene Deletion Aggravates Ischemic Brain Damage

Kenji Nishio¹^*, Masayuki Fujioka²^*, Kazuhide Hayakawa³^*, Kenichi Mishima³^*, Michihiro Fujiwara³^*, Fumiaki Banno⁴^*, Koichi Kokame⁴^*, Toshiyuki Miyata⁴^*, Yasuaki Shida⁵^*, Mitsuhiko Sugimoto⁵^*, Hidetada Fukushima¹^* and Kazuo Okuchi¹^*

¹Emergency and Critical Care Medicine, Nara Medical University, Kashihara, Japan
²Neurosurgery, Dresden University of Technology, Dresden, Germany
³Neuropharmacology, Pharmaceutical Science, Fukuoka, Japan
⁴National Cardiovascular Center Research Institute, Suita, Japan
⁵Pediatrics, Nara Medical University, Kashihara, Japan

See more of: Oral and Poster Abstracts

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^*signifies non-member of ASH

302.O1.8 Platelet Adhesion