50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Platelet Activation and Biochemistry Poster I

Saturday, December 6, 2008: 5:30 PM-7:30 PM

Hall A (Moscone Center)

Cytoskeletons of X-Linked GATA-1, G208S Macrothrombocytes Are Deficient in Talin

James G. White, MD¹, Steven M. Burris¹^* and Angela Thomas, M.B., M.S., Ph.D., FRCPE, FRCPCH²^*

¹Department of Laboratory Medicine, Pathology and Pediatrics, University of Minnesota, Minneapolis, MN
²Department of Hematology, Royal Hospital for Sick Children, Edinburgh, Scotland

1830

Identification and Characterization of a Human Platelet Glycoprotein VI Peptidomimetic Permitting Molecular Imaging of Fibrosis

Martine Jandrot-Perrus¹^*, Julien Muzard¹^*, Laure Sarda-Mantel²^*, Stéphane Loyau¹^*, Alain Meulemans³^*, Liliane Louedec¹^*, Florence Hervatin³^*, Jean-Baptiste Michel¹^*, Dominique Le Guludec³^* and Philippe Billiald⁴^*

¹U698, INSERM, Paris, France
²Inserm U773, Hôpital Bichat, Paris
³U773, INSERM, Paris
⁴EA4105, Muséum National d'Histoire Naturelle, Paris, France

1831

RUNX1/CBFA2 Regulates Myosin Light Chain 9 (MYL9) in Megakaryocytic Cells: Decreased MYL9 Expression in Human RUNX1 Haplodeficiency

Gauthami S Jalagadugula, Ph.D¹^*, Gurpreet Kaur, Ph.D¹^*, Guangfen Mao, MD¹^*, Danny Dhanasekaran, Ph.D²^* and A. Koneti Rao, MD¹^*

¹Thrombosis Research Center and Department of Medicine, Temple University School of Medicine, Philadelphia, PA
²Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Phialdelphia, PA

1832

High Mortality in Mice with Platelets Expressing Integrin αIIbβ3 Locked-in Its High Affinity State

David A. Wilcox, PhD¹, Juan Fang, MD¹^*, Paula North, MD, PhD²^*, Paquita Nurden, MD³, Alan T. Nurden, PhD³ and Nathalie Valentin, PhD⁴^*

¹Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI
²Department of Pathology, Medical College of Wisconsin
³CRPP/PTIB, Pessac, France
⁴Laboratoire d'Immunologie, Laboratoire de thérapie génique, INSERM U649, Nantes, France

1833

Complement Factor H in Human Platelets: Implications for Atypical HUS

Walter H.A. Kahr, MD, PhD¹, Fred G Pluthero, PhD²^* and Christoph Licht, MD³^*

¹Division of Haematology/Oncology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada
²The Hospital for Sick Children, Division of Haematology/Oncology, Toronto, ON, Canada
³The Hospital for Sick Children, Division of Nephrology, Toronto, ON, Canada

1834

Impaired Actin Assembly and Lamellipodia Formation in ATE1 Knockout Platelets

Lurong Lian, M.D.¹^*, Anna S. Kashina, Ph.D.²^*, Karen P. Fong, Ph.D.¹^*, Yanfeng Wang, M.D.¹^* and Charles S. Abrams, MD³

¹University of Pennsylvania School of Medicine, Philadelphia, PA
²University of Pennsylvania School of Medicine
³School of Medicine, University of Pennsylvania, Philadelphia, PA

1835

Microfluidic Flow Studies of Murine Thrombus Formation and Stability on Collagen

Andres M. Bur¹^*, Karen P Fong, PhD¹^*, Keith B Neeves, PhD²^*, Sean F Maloney³^*, Scott L. Diamond, PhD³^*, Mark L Kahn, M.D.¹^* and Lawrence F. Brass, MD, PhD¹

¹University of Pennsylvania, Philadelphia, PA
²Department of Chemical Engineering, Colorado School of Mines, Golden, CO
³Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA

1836

Endobrevin/VAMP-8-Mediated Dense Granule Release Is Required for Efficient Thrombus Formation in Vivo

Price S. Blair¹^*, Qiansheng Ren²^*, Gwenda J. Graham¹^*, James R. Dilks¹^*, Sidney W. Whiteheart²^* and Robert C. Flaumenhaft¹

¹Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA
²Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY

1837

TLT-1 (TREM-Like transcript-1) Protects against Hemorrhage Associated with Inflammation by Facilitating Platelet Aggregation

A. Valance Washington, Ph.D.¹^*, Sébastien Gibot, MD²^*, Ismael Acevedo, MD¹^*, Alina De La Mota¹^*, James Gattis, Ph.D.³^*, Linette Rivera¹^*, Laura Quigley⁴^*, Julio Gomez-Rodriguez, Ph.D.⁵^*, Jun Cheng⁵^*, Amalia Dutra⁵^*, Jacek Lubkowski³^*, Evgenia Pak⁵^*, Robert Hunter¹^*, Pamela L Schwartzberg, MD, PhD⁵^* and Daniel W McVicar, Ph.D.⁴^*

¹Anatomy and Cell Biology, Universidad Central del Caribe, Bayamon, PR
²Réanimation Médicale, Hôpital Central; Groupe Choc, Contrat Avenir Inserm; Faculté de Medecine; Nancy Université, France, 54034 Cedex Nancy, France
³Macromolecular Crystallography Laboratory, NCI, Frederick, MD
⁴Cancer and Inflammation Program, NCI, Frederick, MD
⁵National Human Genome Research Institute, NIH, Bethesda, MD

1838

R93W Mutation in Orai1 Causes Impaired Calcium Influx in Platelets

Wolfgang Bergmeier¹, Masatsugu Oh-hora²^*, Christie-Ann McCarl³^*, R. Claire Roden¹^*, Paul F. Bray¹^* and Stefan Feske³^*

¹Medicine, Thomas Jefferson University, Philadelphia, PA
²Immune Disease Institute, Harvard Medical School, Boston, MA
³Department of Pathology, New York University School of Medicine, New York, NY

1839

The Platelet Actin Cytoskeleton Associates Directly with Syntaxin-4 and Participates in α-Granule Secretion

Robert Flaumenhaft, James R. Dilks^*, Nataliya Rozenvayn^* and Kamil Woronowicz^*

Dept. of Medicine, BIDMC, Harvard Medical School, Boston, MA

1840

Lactadherin and Clearance of Platelet-Derived Microvesicles

Swapan Kumar Dasgupta, PhD¹^*, Hanan Abdel-Monem, MD²^*, Polly Niravath, MD³^*, Anhquyen Le, BS¹^*, Ricardo Bellera, MD³^*, Kimberly Langlois, BS³^*, Shigekazu Nagata, MD, PhD⁴^*, Rolando Rumbaut, MD, PhD³^* and Perumal Thiagarajan, MD²

¹Department of Pathology, Baylor College of Medicine, Houston, TX
²Department of Pathology and Medicine, Baylor College of Medicine, Houston, TX
³Department of Medicine, Baylor College of Medicine, Houston, TX
⁴Department of Genetics, Osaka University Medical School, Osaka, Japan

1841

Protein Kinase Cδ Differentially Regulates Platelet Functional Responses

Ramya Chari, MS¹^*, Todd Getz, BS¹^*, Bela Nagy¹^*, Kamala Bhavaraju, MS¹^*, Yingying Mao, MS²^*, Yamini Saraswathy Bynagari¹^*, Swaminathan Murugappan¹^*, Keiko Nakayama³^*, James Daniel, PhD⁴^* and Satya P. Kunapuli, Ph.D.¹

¹Physiology, Temple University School of Medicine, Philadelphia, PA
²Temple University School of Medicine, Philadelphia, PA
³Division of Developmental Genetics, Tohoku University Graduate School of Medicine, Sendai Miyagi, Japan
⁴Sol Sherry Thrombosis Center, Temple Univ. School of Med., Philadelphia, PA

1842

The Role of Livin, An Inhibitor of Apoptosis Protein, in Thrombopoiesis

Ihab Abd-Elrahman¹^*, Varda Deutsch², Klilah Hershko³^*, Tsahi Noyman³^*, Itay Lazar¹^*, Boaz Nachmias¹^*, Riki Perlman¹^* and Dina Ben-Yehuda¹

¹Division of Hematology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
²The Hematology Institute, Tel Aviv Medical Center, Israel
³Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

1843

A Novel Histidine Tyrosine Phosphatase, TULA-2, Associates with Syk and Negatively Regulates GPVI Signaling in Platelets

Dafydd H Thomas, BSc¹^*, Carol Dangelmaier, BS²^*, Jianguo Jin, MD²^*, Alexander Tsygankov, Ph.D.³^*, Satya P. Kunapuli, Ph.D.⁴ and James Daniel, PhD⁵^*

¹Pharmacology, Temple University, Philadelphia, PA
²Physiology, Temple University, Philadelphia, PA
³Microbiology & Immunology, Temple University, Philadelphia, PA
⁴Physiology, Temple University School of Medicine, Philadelphia, PA
⁵Sol Sherry Thrombosis Center, Temple Univ. School of Med., Philadelphia, PA

1844

Functional Genomics of the Platelet ADP and Collagen Signalling Pathways

Stephen F Garner¹^*, Chris I Jones²^*, Jonathan Stephens¹^*, Sarah L Bray³^*, Will Angenent⁴^*, Philippa Burns¹^*, Richard W Farndale⁵^*, Catherine Rice⁴^*, Frank Dudbridge³^*, Nick Watkins⁶^*, Bernard de Bono⁷^*, Panos Deloukas⁴^*, Alison H Goodall⁸^* and Willem Ouwehand⁶^*

¹Dept. of Haematology, University of Cambridge & NHS Blood and Transplant, Cambridge, United Kingdom
²University of Reading, Reading, United Kingdom
³MRC Biostatistics Unit, Cambridge, United Kingdom
⁴Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⁵Biochemistry, University of Cambridge, Cambridge, United Kingdom
⁶Haematology, University of Cambridge and NHS Blood and Transplant, Cambridge, United Kingdom
⁷European Bioinformatics Institute, Hinxton, United Kingdom
⁸Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom

1845

Impaired Activation of Platelets Lacking Protein Kinase C Theta (PKCΘ) Isoform

Bela Nagy, MD^*, Kamala Bhavaraju, MS^*, Todd Getz, BS^*, Yamini Saraswathy Bynagari^*, Soochong Kim, PhD^* and Satya P. Kunapuli, Ph.D.

Physiology, Temple University School of Medicine, Philadelphia, PA

1846

Platelet/Megakaryocyte PKC-θ Is a Transcriptional Target of RUNX1/CBFA2: Studies in Human RUNX1 Haplodeficiency

Gauthami S Jalagadugula, Ph.D¹^*, Gurpreet Kaur¹^*, Guangfen Mao, MD¹^*, Danny Dhanasekaran, Ph.D²^* and A. Koneti Rao, MD¹

1847

Thrombospondin 1 (TSP-1) Partially Contributes to Shear or Stirring-Dependent TGF-beta1 Activation In Vitro and During Platelet-Rich Thrombi Formation In Vivo

Jasimuddin Ahamed, PhD, Christin A Janczak^* and Barry S. Coller, MD

Laboratory of Blood and Vascular Biology, The Rockefeller University, New York, NY

1848

Integrin β3 Membrane-Proximal and -Distal Residues Cooperatively Regulate Talin-Mediated αIIbβ3 Activation

Jun Yamanouchi¹, Takaaki Hato, MD², Hiroshi Fujiwara, MD, PhD³, Yoshihiro Yakushijin, MD, PhD⁴^* and Masaki Yasukawa⁵

¹Department of Bioregulatory Medicine, Ehime University Graduate School of Medicine, Toon, Japan
²Div. of Blood Transfusion, Ehime University, Toon, Japan
³Department of Bioregulatory Medicine, Ehime University Graduate school of Medicine, Toon, Japan
⁴Cancer center of Ehime University Hospital, Ehime University Graduate School of Medicine, Toon, Japan
⁵Bioregulatory Medicine, Ehime University Graduate School of Medicine, Toh-on, Japan

1849

A Role for α-Actinin in Inside-out αIIbβ3 Signaling

Seiji Tadokoro¹^*, Masamichi Shiraga²^*, Hirokazu Kashiwagi²^*, Tsuyoshi Kamae²^*, Masao Akiyama²^*, Tsuyoshi Nakazawa²^*, Yuzuru Kanakura² and Yoshiaki Tomiyama³

¹Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
²Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Osaka, Japan
³Department of Blood Transfusion, Osaka University Hospital, Osaka, Japan

1850

Role of Glycoprotein Ibα Mobility in Platelet Function

Dianne E van der Wal¹^*, Sandra Verhoef¹^*, Roger EG Schutgens²^*, Marjolein Peters, MD, PhD³^* and Jan-Willem Akkerman, PhD¹^*

¹Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, Netherlands
²Haematology, University Medical Center Utrecht, Utrecht, Netherlands
³Pediatric hematology, Academic Medical center, Amsterdam, Netherlands

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^*signifies non-member of ASH

301.P1.44 Platelet Activation and Biochemistry Poster I