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301.O2.6 Platelet Activation And Biochemistry II

Monday, December 8, 2008: 11:00 AM-12:30 PM
3002-3004 - West (Moscone Center)
Moderators:
Satya P. Kunapuli, Ph.D. and Donna Woulfe, PhD
11:00 AM
Specific Pharmacological Targeting of the Syk Kinase Activity in Platelets: A Novel, Safe Anti-Thrombotic Strategy

Suzanne Delaney, PhD1*, Uma Sinha, PhD1, Nisha Nanda, PhD1*, Yibing Yan, PhD1*, Anjali Pandey, PhD1*, Stan Hollenbach1*, Whyte Owen, PhD2*, David Phillips, PhD1* and Patrick Andre, Ph.D.1*

1Portola Pharmaceuticals Inc, S San Francisco, CA
2Mayo Clinic College of Medicine, Rochester, MN

11:15 AM
Genetic Evidence for a Predominant Role of PI3Kβ In ITAM- and Integrin-Mediated Signaling in Platelets

Ilaria Canobbio1*, Lucia Stefanini1*, Lina Cipolla1*, Elisa Ciraolo2*, Cristian Gruppi1*, Emilio Hirsch2*, Cesare Balduini1* and Mauro Torti, PhD3

1Department of Biochemistry, University of Pavia, Pavia, Italy
2Molecular Biotechnology Center, Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy
3Dept. of Biochemistry, University of Pavia, Pavia, PV, Italy

11:30 AM
Anti-Thrombotic Effects of Targeting Outside-in αIIbβ3 Signaling in Platelets

Ararat J. Ablooglu, Ph.D.*, Jian Kang, Ph.D.*, Brian G. Petrich, Ph.D.*, Mark H. Ginsberg, M.D.* and Sanford J. Shattil, M.D.

Medicine, University of California San Diego, La Jolla, CA

11:45 AM
Genetic Disruption of lpdl and lpdlr Phospholipases in Mice Leads to Impaired Platelet Adhesion and Aggregation

DingYan Wang1*, Adili Reheman2*, Phil Connelly3*, Youdong Wang1*, Graham Maguire3*, Feng He3*, Armand Keating4, Heyu Ni5 and Xiao-Yan Wen1

1Princess Margaret Hospital, University Health Network, Dept of Medicine, University of Toronto & McLauglin Centre for Molecular Medicine, Toronto, ON, Canada
2St. Michael's Hospital, ON, Canada
3Li Ka Shing Knowledge Institute, St. Michael's Hospital, ON, Canada
4Medical Oncology and Hematology, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada
5Canadian Blood Services, Canada, & Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada

12:00 PM
The Orphan Receptor GPR31 Is the Platelet and HUVEC Receptor for 12(S)-HETE

Steven J Feinmark1*, Michael A. Nardi2, Erin Harleton1*, Liang Hu3*, Ruimin Pan3* and Simon Karpatkin3

1Pharmacology, Columbia University Medical Center, New York, NY
2Pediatric Hematology, NYU School of Medicine, New York, NY
3Medicine/Hematology, NYU School of Medicine, New York, NY

12:15 PM
The beta1-Tubulin Binding Protein RanBP10 Plays a Critical Role for Platelet Discoid Shape and Hemostasis

Harald Schulze, PhD, Silke Fleischhauer*, Imke Meyer*, Martin Wannack* and Stefan Kunert*

Laboratory for Pediatric Molecular Biology, Charite Campus Mitte, Berlin, Germany

*signifies non-member of ASH