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301.O1.6 Platelet Activation And Biochemistry I

Sunday, December 7, 2008: 4:30 PM-6:00 PM
3002-3004 - West (Moscone Center)
Moderators:
Robert K Andrews, Ph.D and Michael Holinstat
4:30 PM
Loss of Individual PIP5KI Isoforms Demonstrate That Spatial PIP2 Synthesis Is Required for Platelet Second Messenger Formation & Integrity of the Actin Cytoskeleton

Yanfeng Wang, M.D.1*, Lurong Lian, M.D.1*, Aae Suzuki1*, Rustem I. Litvinov, M.D.1*, Timothy J. Stalker, Ph.D.1*, Alec A. Schmaier1*, Lawrence F. Brass, MD, PhD2, John Weisel, Ph.D.3* and Charles S. Abrams, MD4

1University of Pennsylvania School of Medicine, Philadelphia, PA
2Univ. of Pennsylvania, Philadelphia, PA
3Dept Cell & Dev Biology, University of Pennsylvania School of Medicine, Philadelphia, PA
4School of Medicine, University of Pennsylvania, Philadelphia, PA

4:45 PM
Arrestin-2 Differentially Regulates PAR4 and P2Y12 Receptor Signaling in Platelets

Dongjun Li, MD, PhD* and Donna Woulfe, PhD

Medicine, Thomas Jefferson University, Philadelphia, PA

5:00 PM
Junctional Adhesion Molecule a Helps Maintain Integrin αIIbβ3 in Resting State

Meghna Ulhas Naik, MS1*, Timothy J. Stalker, Ph.D.2*, Lawrence F. Brass, MD, PhD3 and Ulhas Pandurang Naik, PhD4

1Biological Sciences, University of Delaware, Newark, DE
2University of Pennsylvania School of Medicine, Philadelphia, PA
3Univ. of Pennsylvania, Philadelphia, PA
4University of Delaware, Newark, DE

5:15 PM
The Role of LIM Kinase-1 in the Glycoprotein Ib-IX Complex-Mediated Platelet Activation and Thrombus Formation

Aleksandra Stojanovic, MS*, Matvey Gorovoy, PhD*, Tatyana Voyno-Yasenetskaya, MD, PhD* and Xiaoping Du, MD, PhD

Pharmacology, University of Illinois at Chicago, Chicago, IL

5:30 PM
Platelet Tissue Factor: Expression of Pro-Coagulant Activity depends on Gpibα Activation and Signaling through Lyn-Mediated Phosphorylation. A Platelet-Based Model of Hemostasis

Olga Panes*, Paula Ibarra*, Valeria Matus, PhD*, Claudia G. Sáez, PhD*, Jaime Pereira, MD and Diego Mezzano, MD

Hematology-Oncology, School of Medicine, P. Universidad Católica de Chile, Santiago, Chile

5:45 PM
Bevacizumab Immune Complexes Induce Thrombocytopenia and Thrombosis in Mice Transgenic for Human IgG Receptor FcΥRIIa

Ali Amirkhosravi, Ph.D.1*, Todd V Meyer, Ph.D.1*, Liza Robles-Carillo, MS1*, Florian Langer, MD2*, Theresa Robson, BS1*, Hina Desai, MS1*, Monica Davila, Ph.D.1*, Mildred Amaya, MS1* and John L. Francis, Ph.D.1*

1Center for Thrombosis Research, Florida Hospital, Orlando, FL
2Hematology and Oncology, University Hospital Eppendorf, Hamburg, Germany

*signifies non-member of ASH