50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Lymphocytes and Lymphocyte Activation Poster I

Saturday, December 6, 2008: 5:30 PM-7:30 PM

Hall A (Moscone Center)

Identification of a Human Natural Regulatory T Cell Micro-RNA Signature and Demonstration of the Major Role Played by miR31 in the Control of Foxp3 Expression

Redouane Rouas¹^*, Hussein Fayyad Kazan¹^*, Nabil El Zein¹^*, Philippe Lewalle¹^*, Françoise Rothé¹^*, Haidar Akl¹^*, Arsène Burny¹^*, Pedro Romero²^*, Philippe Martiat³ and Bassam Badran¹^*

¹Experimental Hematology, Institut Bordet (ULB), Brussels, Belgium
²Immunotherapy, Ludwig Institute, Lausanne Branch, Lausanne, Switzerland
³Dept. of Experimental Hem., Institut Jules Bordet, Brussels, Belgium

1527

Generation of T Cells from Human Embryonic Stem Cells

Frank Timmermans, MD¹^*, Imke Velghe²^*, Lieve Van Walleghem, MD³^*, Magda De Smedt²^*, Stefanie Van Coppernolle⁴^*, Georges Leclercq, PhD¹^*, Tom Taghon, PhD¹^*, Harry Moore, PhD⁵^*, Anton W Langerak, PhD⁶^*, Tessa C. C. Kerre, MD, PhD⁷^*, Jean Plum, MD, PhD²^* and Bart Vandekerckhove, MD, PhD²

¹Deptartment of Clinical Chemistry, Microbiology and Immunology, University of Ghent, 9000, Belgium
²Deptartment of Clinical Chemistry, Microbiology and Immunology, University of Ghent, Gent, Belgium
³Department of Pathology, AZ Sint-Jan, Belgium
⁴Immunology, Ghent University Hospital, Gent, Belgium
⁵University of Sheffield, Sheffield, United Kingdom
⁶Department of Immunology, Erasmus University, Rotterdam, Netherlands
⁷Immunology and Hematology, Ghent University Hospital, 9000, AR, Belgium

1528

Identification of Plasma Cell Antigen PC-1 as a Novel Cell Surface Marker of Germinal Center, Memory and Plasmacytoma B Cells

Hongsheng Wang¹^*, Natalie Beaty¹^*, Dong-Mi Shin¹^*, Jianxun Feng¹^*, Sophia Chen¹^* and Herbert Morse III, MD²

¹Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD
²NIAID, NIH, Rockville, MD

1529

The Expression Level of HLA-E on Activated T Cells Determines Their Fate When Activated NK Cells Were Nearby Present

Sumiko Takao, MD^*, Takayuki Ishikawa, MD, PhD^* and Takashi Uchiyama, MD, PhD

Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

1530

Cognitive Study of Reactivity to IPH1101 of Peripheral γδ T Lymphocytes from Chronic Myeloid Leukemia, Multiple Myeloma and Follicular Lymphoma Patients

Helene Sicard, PhD¹^*, Jean-Francois Rossi, MD, PhD², Philippe Rousselot, MD³^*, Alexis Collette⁴^*, Christine Paiva¹^*, Sophie Ingoure¹^* and Sylvie Lafaye de Micheaux, MD¹^*

¹Innate Pharma, Marseille, France
²Chu Lapeyronie, Montpellier, France
³Hôpital Mignot and CIC9504, Versailles, France
⁴TexCell Laboratories, Evry Cedex, France

1531

Gene-Modified CD8+ T Cells Undergo Functional Polarization to Effector and Central Memory Cells in Response to Antigen Exposure

Paul Neeson, PhD¹^*, Amanda Shin²^*, Tsin Tai, MSc³^*, Karen Chen²^*, Joanne Davis²^*, Kellie Tainton, BSc⁴^*, Phil Darcy, PhD²^*, Michael H. Kershaw⁵^*, Stefan Peinert⁶, Preethi Guru⁶^*, Simon Harrison⁷^*, H. Miles Prince⁸ and D. Ritchie⁹^*

¹Haematology Immunology Translational Laboratory, Cancer Immunology Research Program, Peter MacCallum Cancer Centre, East Melbourne, Australia
²Cancer Immunology Research Program, Peter MacCallum Cancer Centre, East Melbourne, Australia
³Haematology Immunology Translational Research Laboratory, Cancer Immunology Research Program, Peter MacCallum Cancer Centre, East Melbourne, Australia
⁴Haematology Immunology Translational Research Laboratory, Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Australia
⁵Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Australia
⁶Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, East Melbourne, Australia
⁷Dept. of Hematology, Peter MacCallum Cancer Center, Melbourne, VIC, Australia
⁸Department of Haematology, Peter MacCallum Cancer Center, Melbourne, Australia
⁹Department of Heamatology and Clinical Oncology., Peter MacCallum Cancer Centre, East Melbourne, Australia

1532

Rapid Immunoprofiling of New Lymphocytosis Cases Using a Routine Hematology Analyzer: A Multicenter Study

Henk Adriaansen, MD, PhD¹^*, Gita A van den Berg, PhD²^*, Martin H. Herruer, PhD³^*, Joost Schuitemaker⁴^*, Jan W. Smit, PhD⁵, Tanja van Weel⁶^* and Johannes J Hoffmann, PhD⁷^*

¹Clinical Chemistry and Hematology Laboratory, Gelre Hospitals, Apeldoorn, Netherlands
²Clinical Chemistry Laboratory, Stg. KCL, Leeuwarden, Netherlands
³Medial Medical Diagnostic Laboratories, Hoofddorp, Netherlands
⁴Product Development, IQ Products, Groningen, Netherlands
⁵Lab. Noord, Groningen, Netherlands
⁶Clinical Chemistry Laboratory, Tergooi Hospitals, Blaricum, Netherlands
⁷Diagnostics Division, Abbott Laboratories, Wiesbaden-Delkenheim, Germany

1533

The Critical Role of Iκbα Dependent Nuclear Export of NF-κb in B-Cell Development

David T Yang, MD¹, Shelly Wuerzberger-Davis, PhD¹^*, Yuhong Chen, PhD²^*, Mei Yu²^*, Hu Zeng²^*, Paul Bates, PhD¹^*, Renren Wen, PhD²^*, Demin Wang, PhD²^* and Shigeki Miyamoto, PhD¹^*

¹Pharmacology, University of Wisconsin School of Medicine and Public Health, Madison, WI
²The Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI

1534

Humoral Immune Responses against the Immature Laminin Receptor Show Prognostic Significance in Patients with Multiple Myeloma

Matthias Zeis¹^*, Sandra Siegel²^*, Birte Friedrichs³^* and Norbert Schmitz, MD, PhD⁴

¹Department of Hematology & Stem cell transplantation, Asklepios Clinic St. Georg, Hamburg, Germany
²Department of Hematology & Stem cell transplantation, Asklepios Clinic St. Georg, Hamburg
³Medical Clinic III, Charite-Campus Benjamin Franklin, Berlin, Germany
⁴Hematology and Stem Cell Transplantation, Asklepios Klinik St. Georg, Hamburg, Germany

1535

The Src-Like Adaptor Proteins, SLAP and SLAP2, Regulate Flt3-Dependent Dendritic Cell Development

Larissa Liontos^* and C. Jane McGlade, PhD^*

Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada

1536

Suppression of Allogeneic Immune Responses by Human TCRαβ⁺ CD4^-CD8^- Double-Negative T Cells

Simon Voelkl^*, Regina AM Gary^* and Andreas Mackensen, MD

Dept. of Internal Medicine V, Hematology/Oncology, Erlangen, Germany

1537

Clinical Implications of Killer Cell Immunoglobulin-Like Receptor (KIR) Genotypes on Autologous Peripheral Blood Stem Cell Transplantation for Acute Myelogenous Leukemia Patients

Heeje Kim, Young Choi^*, Tai-Hyang Lee^*, Dong-Hoon Hahn^*, Hoei-Sung Gang^* and Woo-Sung Min^*

Internal Medicine, Catholic Hemopoietic Stem Cell Transplantation Center, St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, South Korea

1538

Targeting of alpha4beta1 Integrin and CD4/CD8 on Human T Cells, in Addition to CD3 and CD28, Induces Maximal Activation, as Assessed by Single-Cell Analysis of MAP Kinase Pathway Activation and Cytokine Production

Tae Kon Kim, M.D.¹^*, Matthew J. Billard, Ph.D.²^*, Eric D. Wieder, Ph.D.¹, Bradley W. McIntyre, Ph.D.²^* and Krishna V. Komanduri, M.D.¹^*

¹Stem Cell Transplant Program, Department of Medicine, University of Miami, Miami, FL
²Immunology, M.D. Anderson Cancer Center, Houston, TX

1539

T Cells Demonstrate Enhanced Specificity for CD19⁺ Malignancies When Stimulated with IL-21

Harjeet Singh, MS, PhD¹, Mary Helen Huls, BS¹^*, Margaret J. Dawson, BS¹^*, Tiejuan Mi, MS¹^*, Gianpietro Dotti, MD²^*, Dean A. Lee, MD, PhD¹^*, Partow Kebriaei, MD³^*, Elizabeth J. Shpall, MD³^*, Perry B. Hackett, PhD⁴^*, Carl H. June, MD⁵, Richard E. Champlin, MD³^* and Laurence J.N. Cooper, MD, PhD¹

¹Pediatrics, U.T. M.D. Anderson Cancer Center, Houston, TX
²Medicine, Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital and Texas Children's Hospital, Houston, TX
³Stem Cell Transplantation, U.T. M.D. Anderson Cancer Center, Houston, TX
⁴Genetics, Cell Biology and Development, University of Minnesota, St. Paul, MN
⁵Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA

1540

^{Early Human B-Lineage Cells Can Make Functional Igκ Gene Rearrangements and Express Igκ Protein in the Absence of Functional VDJH Rearrangements.}

Sonja E. Nodland, PhD¹^*, Anna Bajer¹^*, Menno C. van Zelm, PhD²^*, Jacques J.M. van Dongen, MD²^* and Tucker W. LeBien, PhD¹

¹Masonic Cancer Center, University of Minnesota, Minneapolis, MN
²Department of Immunology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands

1541

Inflammatory Cytokine Levels in the Peri-Stem Cell Transplantation Period Correlate with Fluctuations in Peripheral Blood Counts but Not with Inflammation

J. Joseph Melenhorst, PhD¹, Angelique Biancotto, PhD²^*, Phillip Scheinberg, MD³^*, Colin O. Wu, PhD³^*, J. Philip McCoy, PhD³, Priscila Scheinberg⁴^*, Nancy F Hensel⁴^* and A. John Barrett, MD, FRCP⁵

¹National Institutes of Health, NHLBI, Bethesda, MD
²NHLBI/NIH, Bethesda, MD
³Nhlbi, National Institutes of Health, Bethesda, MD
⁴Hematology, NHLBI/NIH, Bethesda, MD
⁵NHLBI, NIH, Bethesda, MD

1542

Telomere Elongation in B-Cells Is Independent of Class Switching

Alexander Roeth, MD¹, Dirk de Beer²^*, Marc Seifert³^*, Astrid Mueller²^*, Ulrich Duehrsen, MD¹, Ralf Kueppers, PhD³^* and Gabriela M. Baerlocher, MD⁴

¹Department of Hematology, University Hospital Essen, Essen, Germany
²Department of Clinical Research, University of Bern, Bern, Switzerland
³Institute of Cell Biology (Tumor Research), University Duisburg-Essen, Essen, Germany
⁴Department of Hematology and Department of Clinical Research, University Hospital Bern, Bern, Switzerland

1543

Rheumatoid Arthritis as a New Disease-Target for Bortezomib

Evangelia Yannaki, MD¹, Anastasia Papadopoulou, PhD, student²^*, Argyrw Paraskeva, BS³^*, Panayotis Kaloyannidis, MD¹^*, Evangelia Athanasiou, MD²^*, Dimitris Bougiouklis, BS²^*, Panayotis Palladas, MD⁴^*, Minas Yiangou, PhD³^*, Athanasios Fassas, MD¹^* and Achilles Anagnostopoulos⁵

¹GENE and CELL THERAPY CENTER, HEMATOLOGY-BMT UNIT, GEORGE PAPANICOLAOU HOSPITAL, Thessaloniki, Greece
²GENE and CELL THERAPY CENTER, GEORGE PAPANICOLAOU HOSPITAL, Thessaloniki, Greece
³Department of Genetics, Development & Molecular Biology, School of Biology,, ARISTOTLE UNIVERSITY, Thessaloniki, Greece
⁴Radiology, GEORGE PAPANICOLAOU HOSPITAL, Thessaloniki, Greece
⁵Hematology Department- Bone Marrow Transplantation Unit, George Papanicolaou Hospital, Thessaloniki, Greece

1544

Dendritic Cells, Generated and Matured, after Elutriation, in Clinical Grade Bags, Differ in Immune Functions When Compared to Classical DCs Generated in Plates

Redouane Rouas¹^*, Haidar Akl¹^*, Bassam Badran²^*, Larissa Di Pietrantonio¹^*, Hugues Duvillier¹^*, Philippe Martiat³ and Philippe Lewalle¹^*

¹Dept. of Experimental Hem., Institut Jules Bordet, Brussels, BEL
²Experimental Hematology, Institut Bordet (ULB), Brussels, Belgium
³Dept. of Experimental Hem., Institut Jules Bordet, Brussels

1545

Tec Kinase Inhibits the Expression of IL-2 Receptor Alpha (CD25) in Human T-Lymphocyte

Kentaro Susaki¹^*, Akira Kitanaka², Hiroaki Dobashi¹^*, Katsuharu Kittaka¹^*, Hiroyuki Mano³^*, Yoshitsugu Kubota⁴^* and Terukazu Tanaka⁵^*

¹First Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kita-gun, Kagawa, Japan
²Department of Laboratory Medicine, Faculty of Medicine, Kagawa University, Kita-gun, Kagawa, Japan
³Division of Functional Genomics, Jichi Medical University, Shimotsuke-shi, Tochigi, Japan
⁴Department of Transfusion Medicine, Faculty of Medicine, Kagawa University, Kita-gun, Kagawa, Japan
⁵Environmental Health Sciences, Faculty of Medicine, Kagawa University, Kita-gun, Kagawa, Japan

1546

Characterization of An NKp46⁺ NKT Subset Which Is Susceptible to Malignant Transformation in Vivo

Takeki Mitsui¹^*, Jianhua Yu²^*, Akihiko Yokohama¹, Tiffany L Hughes²^*, Mithun V Shah³^*, Thomas P. Loughran Jr.³ and Michael A. Caligiuri⁴

¹Medicine and Clinical Science, Gunma University Graduate School of Medicine, Maebashi, Japan
²Comprehensive Cancer Center, The Ohio State University, Columbus, OH
³Penn State Hershey Cancer Institute, Hershey, PA
⁴James Cancer Hospital & Solove Research Institute, The Ohio State University, Columbus, OH

1547

BCX-4208 (RO5092888), a Purine Nucleoside Phosphorylase (PNP) Inhibitor, Is a Novel, Potent Orally Active Anti-T-Cell and B-Cell Agent

Shanta Bantia, PhD^*, Cynthia Parker^*, Ramanda Upshaw^*, John Michael Kilpatrick, PhD^*, Amanda Cunningham^*, Jianwen Zhang, PhD^*, Pravin Kotian, PhD^*, Philip Morris, PhD^*, Pooran Chand, PhD^* and Yarlagadda S. Babu, PhD^*

BioCryst Pharmaceuticals Inc, Birmingham, AL

1548

The Effects of Atorvastatin on Hematological and Inflammatory Parameters

Gurhan Kadikoylu¹^*, Hilal Bektas Uysal¹^*, Cigdem Yenisey²^*, Irfan Yavasoglu¹^* and Zahit Bolaman, MD³

¹Hematology, ADNAN MENDERES UNIVERSITY MEDICAL FACULTY, Aydin, Turkey
²Biochemistry, ADNAN MENDERES UNIVERSITY MEDICAL FACULTY, Aydin, Turkey
³Hematoloji, Adnan Menderes Universitesi, Aydin, Turkey

1549

Dissection of the Human Pre-B Cell Receptor (pre-BCR) Signalling Cascade

Kaiss Lassoued^*, Stella Ibata^*, Isabelle Piec^*, Celine Alleaume^*, Bertrand Brassard^*, Remy Nyga^*, Vincent Fuentes^* and Hicham Bouhlal^*

Immunology and Hematology, INSERM U925, Amiens, France

1550

Role of Human NK Cells in Dentric-Cell Based Vaccine

Gerard M.J. Bos, MD, PhD, Janine CHMJ Van Elssen^*, Joris Vanderlocht^*, Brigitte LMG Senden-Gijsbers^* and Wilfred LMG Germeraad^*

Dept. of Internal Medicine, University Hospital Maastricht, Maastricht, Netherlands

1551

Malignant B Cell-Derived TGF-ß Controls the Generation of T_H1, T_H17 and T_reg Cells in the Tumor Microenvironment of B-Cell Non-Hodgkin Lymphoma (NHL)

Zhi-Zhang Yang, MD¹, Anne Novak, PhD², Thomas E. Witzig³^* and Stephen M. Ansell⁴

¹Hematology Research, Mayo Clinic, Rochester, MN
²Mayo Foundation, Rochester, MN
³Hematology, Mayo Clinic, Rochester, MN
⁴Mayo Clinic, Rochester, MN

1552

Functional IDO Is Expressed on CD34⁺- and Monocyte-Derived Dendritic Cells According to Differentiation Status

Antonio Curti¹^*, Sara Trabanelli¹^*, Chiara Onofri¹^*, Sergio Rutella, MD, PhD², Raimondo De Cristofaro, MD³^*, Michele Baccarani¹^* and Roberto M Lemoli¹^*

¹Institute of Hematology Seragnoli, Bologna, Italy
²Hematology, Catholic University Medical School, Rome, Italy
³Medicine, Catholic University Medical School, Rome, Italy

1553

Regulatory T Cells Expanded by Autologous Mature Human Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase Are Potent Suppressors of T Cell Proliferation

David J. Chung, MD, PhD¹, Marco Rossi, MD¹^*, Emanuela Romano, MD¹^*, Jennifer Pressley, MS¹^*, Christophe Antczak, PhD¹^*, David H. Munn, MD²^* and James W. Young, MD¹^*

¹Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY
²Pediatrics, Medical College of Georgia, Augusta, GA

1554

Human Langerhans-Type Dendritic Cells Break Tolerance against the Tumor Antigen, WT1, by a Largely IL-15-Dependent Mechanism

Emanuela Romano, MD¹^*, Rosa Barreira da Silva, BS²^*, Sharanya Chandrasekar, MS¹^*, Christian Münz, PhD²^*, Glenn Heller, PhD³^* and James W. Young, MD¹

¹Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY
²Immunology, The Rockefeller University, New York, NY
³Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY

1555

Phenotypic and Functional Effects of Novel Akt Inhibitor Perifosine on Immune System

Weihua Song, MD¹, Teru Hideshima, MD, PhD¹, Yu-Tzu Tai, PhD¹, Kenneth C. Anderson, MD¹ and Nikhil C. Munshi, MD²

¹Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
²Medical Oncology, Dana-Farber Cancer Institute, Boston VA Healthcare System, Harvard Medical School, Boston, MA

1556

Specific Induction of Granzyme B in Human B Cells by Viral Antigens

Magdalena Hagn, MD^*, Julia Maier^*, Tatjana Syrovets, PhD^*, Thomas Simmet, MD^* and Bernd Jahrsdoerfer, MD

Department of Clinical Pharmacology, University of Ulm, Ulm, Germany

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^*signifies non-member of ASH

203.P1.62 Lymphocytes and Lymphocyte Activation Poster I