50th ASH Annual Meeting and Exposition (December 6

Monday, December 8, 2008: 3:30 PM-5:30 PM

2006-2008 - West (Moscone Center)

Moderators:

Young-June Kim, PhD and Crystal L Mackall, M.D.

3:30 PM

RIAM Regulate Spatio-Temporal Distribution of PLC-γ1 and Calcium Mobilization during T Cell Activation

Nikolaos Patsoukis, PhD¹^*, Esther M Lafuente, PhD¹^*, Paul Meraner²^*, Lequn Li, MD, PhD³^*, David Dombkowski⁴^*, Anjana Rao⁵^* and Vassiliki Boussiotis, MD, PhD¹^*

¹Hematology-Oncology and Cancer Biology, Harvard Institutes of Medicine, Beth Israel Deaconess Medical Center, Boston, MA
²Center for Blood Research, Harvard Medical School, Boston, MA
³Hematology Oncology and Cancer Biology, Harvard Institutes of Medicine, Beth Israel Deaconess Medical Center, Boston, MA
⁴Pathology, Massachusetts General Hospital, Boston, MA
⁵Brigham and Women's Hospital, Cambridge, MA

3:45 PM

674

Enhanced Interaction Between Hsp90 and Raptor Regulates mTOR Signaling upon T Cell Activation

Greg M Delgoffe¹^*, Thomas P. Kole, PhD¹^*, Robert J Cotter, PhD²^* and Jonathan Powell, MD, PhD¹

¹Johns Hopkins School of Med., Baltimore, MD
²Pharmacology, Johns Hopkins School of Med., Baltimore, MD

4:00 PM

675

TOR Complex 1 and TOR Complex 2 Differentially Regulate Effector and Regulatory T Cell Differentiation

Greg M Delgoffe¹^*, Thomas P. Kole, PhD¹^*, Yan Zheng, PhD¹^*, Bo Xiao, MD, PhD¹^*, Paul F. Worley, MD¹^*, Sara C Kozma, PhD²^* and Jonathan Powell, MD, PhD¹

¹Johns Hopkins School of Med., Baltimore, MD
²Genome Research Institute, University of Cincinnati, Cincinnati, OH

4:15 PM

676

CO-Culture with Mesenchymal Cells Modulates TGF-Beta/Smad And Mapk Pathways in T Regulatory Cells

Mauro Di Ianni¹^*, Beatrice Del Papa²^*, Lorenzo Moretti²^*, Simonetta Piattoni²^*, Debora Cecchini²^*, Elisabetta Bonifacio²^*, Franca Falzetti²^* and Antonio Tabilio¹^*

¹Department of Internal Medicine and Public Health, University of L'Aquila, Chair of Haematology, L'Aquila, Italy
²Department of Clinical and Experimental Medicine, University of Perugia, Hematology and Clinical Immunology Section, Perugia, Italy

4:30 PM

677

IgG-Derived Tregitope Peptides Suppress T Cell Responses in Vitro and in Vivo

Anne S. De Groot, M.D.¹^*, Leonard Moise, Ph.D²^*, Yan Su, Ph.D³^*, Julie A McMurry²^*, William D Martin⁴^* and David W. Scott, PhD³

¹Institute for Immunology and Informatics, University of Rhode Island, Alpert Medical School at Brown University, and EpiVax, Inc., Providence, RI
²Research and Development, EpiVax, Inc., Providence, RI
³School of Medicine, University of Maryland, Baltimore, MD
⁴Research and Development, EpiVax, Inc., Providence

4:45 PM

678

Tumor-Mediated Suppression of Myeloid to Dendritic Cell Differentiation Via Down Regulation of Protein Kinase C βII Expression

Matthew R. Farren, B.S.^*, Louise M Carlson, PhD^* and Kelvin P. Lee, MD

Immunology, Roswell Park Cancer Institute, Buffalo, NY

5:00 PM

679

In Vivo Administration of Interleukin 15 (IL-15) Safely Promotes the Survival and Proliferation of Adoptively Transferred Antigen-Specific T Cell Clones

Carolina Berger, MD¹, Michael Berger¹^*, Michael C Jensen, MD²^* and Stanley R Riddell, MD¹^*

¹Fred Hutchinson Cancer Research Center, Seattle, WA
²Cancer Immunotherapeutics, City of Hope, Duarte, CA

5:15 PM

680

Inhibition of Syk Activity Is Sufficient for Inhibitory Effect in Animal Models of Autoimmune Diseases

Stanley J Hollenbach^*, Greg Coffey^*, Francis R DeGuzman^*, Mayuko Inagaki^*, Anjali Pandey^*, Zhaozhong J Jia^*, Qing Xu^*, Shawn Bauer^*, Dale Baker, Nisha Nanda^*, David R Phillips and Uma Sinha

Portola Pharmaceuticals Inc, S San Francisco, CA

See more of: Oral and Poster Abstracts

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^*signifies non-member of ASH

203.O2.8 T Cell Biology