50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Granulocytes, Monocytes, and Macrophages Poster I

Saturday, December 6, 2008: 5:30 PM-7:30 PM

Hall A (Moscone Center)

1255

CD300f Triggering Modifies Myeloid Cell Function

Derek Hart, PhD, Courtney Modra^* and Georgina Clark^*

Mater Medical Research Inst., Brisbane, QLD, Australia

1256

M-CSF Inhibition Selectively Targets Tumor Angiogenesis and Lymphangiogenesis

Yoshiaki Kubota¹^* and Toshio Suda, MD²

¹Department of Cell Differentiation, Keio University, Tokyo, Japan
²Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, Tokyo, Japan

1257

Immune Response of Human Polymorphnuclear Neutrophils to Aspergillus Fumigatus

Juergen Loeffler¹^*, Iwona Wozniok¹^*, Markus Mezger¹^* and Hermann Einsele, MD²

¹Medizinische Klinik II, Wuerzburg, Germany
²Medizinische Klinik II, Wurzburg, Germany

1258

Differential Stimulation of Monocytic Cells Results in Distinct Populations of Microparticles

Emily K. Waters, PhD¹, Michael Bernimoulin, MD¹, Martina Foy, PhD²^*, Brian M. Steele, PhD²^*, Matthew Sullivan, PhD²^*, Herve Falet, PhD³, John H. Hartwig, PhD³, Patricia B. Maguire, PhD²^* and Denisa D. Wagner, PhD¹

¹Harvard Medical School, Immune Disease Institute, Boston, MA
²School of Biomolecular and Biomedical Science, UCD Conway Institute, Dublin 4, Ireland
³Brigham & Women's Hospital, Boston, MA

1259

Familial Hemophagocytic Lymphohistiocytosis Type IV: Possible Founder Effect in Syntaxin 11 Gene Common Mutation Endemic to Turkish Population

Gunay Balta¹^*, Umran Caliskan²^*, Elif Guler³^*, Turkan Patiroglu⁴^*, Ahmet F. Oner⁵^* and Aytemiz Gurgey¹^*

¹Department of Pediatrics, Section of Pediatric Hematology, Hacettepe University, Faculty of Medicine, Ankara, Turkey
²Selcuk University, Meram Faculty of Medicine, Konya, Turkey
³Department of Pediatric Oncology, Sahinbey Research Center, Gaziantep, Turkey
⁴Department of Pediatrics, Erciyes University, Kayseri, Turkey
⁵Department of Pediatrics, Yuzuncu Yil University, Van, Turkey

1260

T-Cell Receptor Complementarity Determining Region Analysis of Peripheral Blood and Bone Marrow T-Lymphocyte Subsets and Quantitative Evaluation of T-Regulatory Cells in Patients with Chronic Idiopathic Neutropenia

Michael Spanoudakis¹^*, Antonia Antoniou¹^*, Maria Velegraki¹^*, Katerina Pyrovolaki¹^*, Maria Ximeri¹^*, George D. Eliopoulos¹^*, Kostas Stamatopoulos²^* and Helen A. Papadaki, MD, PhD¹

¹Dept. of Hematology, Univ. Hosp. of Heraklion, Heraklion, Crete, Greece
²Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece

1261

The Second Signal in Antigen-Presenting Cells: Complementary JAK1/JAK2 and CD40 Signalling Mediate Pro-Inflammatory Activation

Michael Conzelmann¹^*, Elena Rodionova²^*, Michael Hess²^*, Annika Zota²^*, Thomas Giese³^*, Andreas Wagner⁴^*, Stephen Breit⁵^*, Markus Hecker⁴^*, Anthony D. Ho¹, Peter Dreger¹^* and Thomas Luft¹^*

¹Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany
²Adaptive Immune Regulation, German Cancer Research Center, Heidelberg, Germany
³Immunology, University of Heidelberg, Heidelberg, Germany
⁴Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
⁵Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany

1262

Expression of MICA by Granulocytes in Neutropenia Due to Large Granular Lymphocyte Leukemia Points towards Cytotoxicity Exerted Via NKG2D on Clonal Cytotoxic T Cells

Aaron D. Viny, BS¹^*, Michael Clemente, MS²^*, Monika Jasek, PhD²^*, Courtney Prince, BS²^* and Jaroslaw P. Maciejewski, MD, PhD²

¹Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH
²Experimental Hematology and Hematopoiesis Section, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH

1263

In Vitro Analyses of Umbilical Cord Blood (UCB) Derived Monocytes Support Adjunct Topical Application to Augment Platelet Rich Plasma (PRP) in Wound Healing

Graham C. Chapman, BSc¹^*, Nicholas Greco, PhD²^*, Richard Patrick Weitzel, BSc²^*, Phil Paul, PhD¹^*, Peter Haviernik, PhD²^*, Mathew L. Lesniewski, PhD²^*, Aaron R. Victor²^*, Gordon Preston²^* and Mary J. Laughlin, MD³

¹Abraham J & Phyllis Katz Cord Blood Foundation, dba Cleveland Cord Blood Center, Cleveland, OH
²Case Western Reserve University, Cleveland, OH
³Medicine, CWRU, Case Medical Center, and Abraham J & Phyllis Katz Cord Blood Foundation, dba Cleveland Cord Blood Center, Cleveland, OH

1264

The Clinical Course of Untreated Gaucher Disease in 22 Patients Over 10 Years: Hematological and Skeletal Manifestations

Siavash Piran, MSc¹^*, Andrew Roberts, BSc²^*, Mary Anne Patterson, RN³^* and Dominick Amato, MD⁴

¹Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada
²Faculty of Science, Queens University, Kingston, ON, Canada
³Centre for Gaucher Disease, Mount Sinai Hospital, Toronto, ON, Canada
⁴Department of Medicine, Mount Sinai Hospital, Toronto, ON, Canada

1265

Gaucher Disease: A Systematic Review and Meta-Analysis of Bone Complications and Their Response to Treatment

Siavash Piran, MSc¹^* and Dominick Amato, MD²

¹Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada
²Department of Medicine, Mount Sinai Hospital, Toronto, ON, Canada

1266

Integrin-Independent Role of CalDAG-GEFI in Neutrophil Chemotaxis

Carla Carbo¹^*, Tobias Goerge, MD¹^*, Hidenori Hattori, MD, PhD²^*, Daniel Duerschmied, MD¹^*, Stephen M. Cifuni¹^*, Hongbo R. Luo, PhD² and Denisa D. Wagner, PhD¹

¹Harvard Medical School, Immune Disease Institute, Boston, MA
²Children's Hosp. Boston, Harvard Med. School and, Boston, MA

1267

Ficolin-1 Is Present in a Highly Mobilizable Subset of Human Neutrophil Granules and Associates with the Cell Surface after Stimulation with fMLP

Sara Roervig, MD¹^*, Christian Honore, MS²^*, Lars-Inge Larsson, MD³^*, Sophie Ohlsson, MD¹^*, Corinna cavan Pedersen, MS¹^*, Lars Christian Jacobsen, Ph.D.¹^*, Jack B. Cowland, MS, PhD⁴, Peter Garred, MD²^* and Niels Borregaard, MD, PhD⁵

¹Granulocyte Research Lab -9322, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
²Clinical Immunology-7631, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
³Anatomy and Cell Biology, Faculty of Life Sciences University of Copenhagen, Frederiksberg C, Denmark
⁴Hematology 93.2.2, Granulocyte Research Laboratory, Copenhagen, Denmark
⁵Granulocyte Research Lab., Copenhagen, Denmark

1268

The Role of Endothelial PECAM-1 Polymorphism (S536N) as Heterophilic Counter Receptor for Neutrophil Specific CD177 in Transendothelial Cell Migration

Behnaz Bayat¹^*, Cornelia Andrei-Selmer²^*, Silke Werth¹^*, Peter Newman³^* and Sentot Santoso¹

¹Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen, Germany
²Department of Neurology, Biomedical Research Center Marburg, Philipps University Marburg Department of Neurology, Marburg, Germany
³Blood Research Institute Milwaukee USA

1269

Glia Maturation Factor-Gamma Mediates Neutrophil Chemotaxis Via p38 MAPK and PTEN

Wulin Aerbajinai¹^*, Kyung Chin²^*, Jianqiong Zhu³^*, Hongzhen Li³^* and Griffin P Rodgers⁴

¹Molecular and Clinical Hematology Branch, NIDDK/NIH, Bethesda, MD
²Molecular and Clinical Hematology Branch,, NIDDK/NIH, Bethesda,, MD
³Molecular and Clinical Hematology Branch,, NIDDK/NIH, Bethesda, MD
⁴Molecular and Clinical Hematology Branch, NIDDK, National Institutes of Health, Bethesda, MD

1270

Identification of New CD177 Isoform in NB1 Deficient Individuals

Behnaz Bayat^*, Karin Kissel^*, Silke Werth^* and Sentot Santoso

Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen, Germany

1271

A Multicenter, Randomized, Dose Frequency Study of the Safety and Efficacy of Cerezyme® Infusions Every 4 Weeks Versus Every 2 Weeks in the Maintenance Therapy of Patients with Type 1 Gaucher Disease

Priya S Kishnani, MD

Pediatrics, Duke University Medical Center, Durham, NC

1272

GM-CSF Controls Proliferation and Survival of the Granulocyte Lineage through the Transcription Factors STAT5A/B

Akiko Kimura, MD, PhD¹, Michael A. Rieger²^*, WeiPing Chen³^*, James M. Simmon⁴^*, Gertraud Robinson¹^*, BingMei Zhu¹^*, John O'Shea⁵^*, Timm Schroeder²^* and Lothar Hennighausen¹^*

¹Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD
²Hematopoiesis Group, Institute of Stem Cell Research, Helmholtz Zentrum M�nchen - German Research Center for Environmental Healt, Neuherberg Munich, Germany
³Microarray Core Facility, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health;, Bethesda, MD
⁴Flow Cytometry Section, Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Disease, National Institutes of Health, Bethesda, MD
⁵Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Disease, National Institutes of Health, Bethesda, MD

1273

Functional Characterization of Signaling Events Underlying Immunostimulatory and Immunosuppressive Activity of Macrophages

Mercedes Kloss^*, Lothar Kanz, MD, Helmut R Salih, MD and Matthias Krusch, MD^*

Hematology and Oncology, Eberhard Karls University, Tuebingen, Germany

1274

Gene-Specific Effects of the Histone Deacetylase Inhibitor TSA on Activation of a Pro-Inflammatory Endothelial Cell Phenotype by the Major Phagocyte Peroxidase-Derived Oxidant HOSCN

Teena Pasrija, Ph.D.¹^*, Shawn A Mahmud, Ph.D.²^*, John D Belcher, Ph.D.²^*, Gregory M. Vercellotti, MD³ and Arne Slungaard, MD⁴

¹Medicine, University of Minnesota, St. Louis Park, MN
²University of Minnesota
³Medical School, University of Minnesota, Minneapolis, MN
⁴University of Minnesota, Minneapolis, MN

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^*signifies non-member of ASH

201.P1.37 Granulocytes, Monocytes, and Macrophages Poster I