50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Fetal Hemoglobin Activation

Monday, December 8, 2008: 1:30 PM-3:00 PM

2006-2008 - West (Moscone Center)

Moderators:

J. Eric Russell, MD and M. A. Bender, MD, PhD

1:30 PM

Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific Repressor BCL11A

Vijay G Sankaran, MPhil, MS¹^*, Tobias F. Menne, MD, PhD, MRCP, FRCPath¹^*, Thomas E. Akie¹^*, Guillaume Lettre, PhD¹^*, Joel N. Hirschhorn, MD, PhD¹^*, Alan B Cantor, MD, PhD¹ and Stuart H. Orkin, MD²

¹Division of Hematology/ Oncology, Children's Hospital Boston, Boston, MA
²Dana-Farber Cancer Institute, Boston, MA

1:45 PM

488

Functional Characterisation of a MYB-HBS1L Intergenic Region Controlling Fetal Hemoglobin Levels in Adults

Karin E Wahlberg, MSc¹^*, Jie Jiang, BSc, PhD¹^*, Helen Rooks, BSc¹^*, Steve Best, BSc, PhD¹^* and Swee Lay Thein²

¹Molecular Haematology, King's College London, School of Medicine, London, United Kingdom
²Kings College London, London, United Kingdom

2:00 PM

489

5-Azacytidine Induces Human Fetal Hemoglobin Production through Activation of the p38 MAPK and Integrated Stress Response Signaling Pathways

Rodwell Mabaera¹^* and Christopher H. Lowrey, MD²

¹Pharmacology & Toxicology, Dartmouth Medical School, Lebanon, NH
²Dartmouth-Hitchcock Med. Ctr., Lebanon, NH

2:15 PM

490

The Role of DNA Damage/Stress Response Pathways in the Mechanism of Action of Decitabine

Vinzon Ibanez, M.S.¹^*, Virryan Banzon, M.S.¹^*, Tatiana Kousnetzova, MS¹^*, Kestis Vaitkus¹^*, Kenneth Peterson, PhD², Joseph DeSimone, PhD¹ and Donald Lavelle, PhD¹

¹Medicine, University of Illinois at Chicago, Chicago, IL
²Univ. of Kansas Medical Center, Kansas City, KS

2:30 PM

491

Structural Analysis of a Methyl Cytosine-Binding Protein Complex That Regulates Expression of Fetal /Embryonic Globin Genes

David C. Williams Jr., MD, PhD¹, Heather D Webb¹^*, J. Neel Scarsdale²^* and Gordon D. Ginder, MD³

¹Pathology, Virginia Commonwealth University, Richmond, VA
²Biochemistry, Virginia Commonwealth University, Richmond, VA
³Virginia Commonwealth Univ., Massey Cancer Center, Richmond, VA

2:45 PM

492

Hereditary Persistence of Fetal Hemoglobin: Old, New and Future Mutations in the ^aγ-Globin Gene-Proximal Region

Kenneth R Peterson, PhD, Halyna Fedosyuk^* and Flavia C Costa, PhD^*

Biochemistry & Molecular Biology, Univ. of Kansas Medical Center, Kansas City, KS

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^*signifies non-member of ASH

112.O2.6 Fetal Hemoglobin Activation