50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Thalassemia: Basic and Clinical Studies

Sunday, December 7, 2008: 4:30 PM-6:00 PM

2006-2008 - West (Moscone Center)

Moderators:

Swee Lay Thein and Jeffery L Miller, MD

4:30 PM

Oxidative Stress Signaling Pathway of Heme Regulated eIF2α Kinase in mitigating the Severity of β-Thalassemia

Rajasekhar NVS Suragani, Post-Doctoral, Fellow, Sijin Liu, Post-Doctoral, Fellow^*, Wanting Zhao, Technical, Assistant^* and Jane-Jane Chen, PhD

Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA

4:45 PM

128

Increased Hepcidin Expression in Mice Affected by β-Thalassemia Reduces Iron Overload with No Effect on Anemia

Sara Gardenghi, PhD¹^*, Maria Franca Marongiu¹^*, Kristen Muirhead¹^*, Pedro Ramos¹^*, Cindy N. Roy, PhD², Nancy C. Andrews, MD, PhD³, Elizabeta Nemeth, PhD⁴, Antonia Follenzi⁵^*, Eliezer Rachmilewitz, M.D⁶, Patricia Giardina, MD¹, Robert W Grady, PhD¹^* and Stefano Rivella, PhD¹

¹Department of Pediatrics, Hematology-Oncology, Weill Cornell Medical College, New York, NY
²Geriatric Medicine, Johns Hopkins University, Baltimore, MD
³Duke University School of Medicine, Durham, NC
⁴UCLA, Los Angeles, CA
⁵Pathology, Albert Einstein College of Medicine, Bronx, NY
⁶Hematology, The Edith Wolfson Medical Center, Holon, Israel

5:00 PM

129

The G9A Histone Methyltransferase BIX-01294 Reactivates ε-Globin Expression and Blocks Erythroid Differentiation in Primary Baboon Erythroid Progenitor Cell Cultures

Virryan Banzon, M.S.^*, Vinzon Ibanez, M.S.^*, Kestis Vaitkus^*, Tatiana Kousnetzova, MS^*, Joseph DeSimone, PhD and Donald Lavelle, PhD

Medicine, University of Illinois at Chicago, Chicago, IL

5:15 PM

130

Phase 1 Clinical Testing of HQK-1001, a Novel Oral Fetal Globin Gene Inducer

Susan Perrine, MD¹, William C Welch, PhD²^*, Jeffrey Keefer, MD, PhD³^*, Robin L Downey, MD⁴^*, Michael S Boosalis, PhD¹^*, Sally Case, RN²^*, Douglas V Faller, MD, PhD¹ and Ronald Berenson, MD²^*

¹Boston Univ. School of Med., Boston, MA
²HemaQuest Pharmaceuticals, Inc., Boston, MA
³Johns Hopkins Hospital, Baltinore, MD
⁴Charles River Clinical Services Northwest, Tacoma, WA

5:30 PM

131

Tang-Her Jaing, MD¹, Brian Wang, MS²^*, David Gjertson, PhD³^*, Ping Law, PhD², Lawrence Petz, MD²^* and Robert Chow, MD, AM²

¹Division of Hematology/Oncology, Chang Gung Children's Hospital, Taoyuan, Taiwan
²StemCyte International Cord Blood Center, Covina, CA
³UCLA School of Public Health, Los Angeles, CA

5:45 PM

132

Altered Erythroid and Megakaryocytic Differentiation in Mice Expressing a Unique Chromatin Remodeling Domain of Erythroid Krüppel-Like Factor (EKLF)

Valerie M. Jansen¹^*, Tatiana Abramova²^*, Eun-Hee Shim, PhD²^*, Shaji Ramachandran, PhD²^*, Aurelie Desgardin²^*, Vishwas Parekh²^*, Stephen Jane, MD, PhD³ and John M Cunningham, MD²^*

¹Pediatrics, Section of Hematology/Oncology, Molecular Sciences, University of Chicago, University of Tennessee Health Science Center, Chicago, IL
²Pediatrics, Section of Hematology/Oncology, University of Chicago, Chicago, IL
³Royal Melbourne Hospital, Parkville, VIC, Australia

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^*signifies non-member of ASH

112.O1.6 Thalassemia: Basic and Clinical Studies