Scott T. Miller, MD¹, Winfred C. Wang, MD², Rathi V. Iyer, MD^3*, Sohail R Rana, MD^4*, Peter A. Lane Jr., MD^5*, Russell E. Ware, MD, PhD², Renee C Rees, PhD^6* and The BABY HUG Investigators^6*

¹SUNY - Brooklyn, Brooklyn, NY
²St. Jude Children's Research Hospital, Memphis, TN
³Pediatrics, University of Mississippi Medical Center, Jackson, MS
⁴Department of Pediatric and Child Health, Howard University Hospital, Washington DC, DC
⁵School of Medicine, Emory University, Atlanta, GA
⁶Clinical Trials & Surveys, Corp., Baltimore, MD

Russell E. Ware, MD, PhD¹, Renee C. Rees, PhD^2*, Sharada A. Sarnaik, MD³, Rathi V. Iyer, MD^4*, Ofelia A. Alvarez, MD⁵, James F. Casella, MD⁶, Barry L. Shulkin, MD^1*, Eglal Shalaby-Rana, MD^7*, C. Frederic Strife, MD^8*, John H. Miller, MD^9*, Peter A. Lane Jr., MD^10*, Winfred C. Wang^1*, Scott T. Miller, MD¹¹ and The BABY HUG Investigators^2*

¹St. Jude Children's Research Hospital, Memphis, TN
²Clinical Trials & Surveys, Corp., Baltimore, MD
³Children's Hosp. of Michigan, Detroit, MI
⁴University of Mississippi Medical Ctr, Jackson, MS
⁵Univ. of Miami School of Med., Miami, FL
⁶Johns Hopkins Univ. School of Med., Baltimore, MD
⁷Radiology, Children's National Medical Center, Washington DC
⁸Cincinnati Children's Hospital Medical Center, Cincinnait, OH
⁹Radiology, Harbor - UCLA Medical Center, Torrance, CA
¹⁰School of Medicine, Emory University, Atlanta, GA
¹¹SUNY - Brooklyn, Brooklyn, NY

Efemwonkiekie W Iyamu, PhD, MD^*, Harrison A Perdew, BS^* and Gerald M Woods, MD^*

Pediatrics, Children's Mercy Hospital, Kansas City, MO

Zora R. Rogers, MD¹, Renee C. Rees, PhD^2*, Beatrice Files, MD^2*, Rathi V. Iyer, MD^3*, Barry L. Shulkin, MD^4*, Eglal Shalaby-Rana, MD^5*, John H. Miller, MD^6*, Stephen D. Dertinger, PhD^7*, Peter A. Lane, MD^8*, Winfred C. Wang, MD⁴, Russell E. Ware, MD, PhD⁴ and The BABY HUG Investigators^2*

¹Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX
²Clinical Trials & Surveys, Corp., Baltimore, MD
³University of Mississippi, Jackson, MS
⁴St. Jude Children's Research Hospital, Memphis, TN
⁵Children's National Medical Center, Washington DC
⁶Harbor-UCLA Medical Center, Torrance, CA
⁷Litron Laboratories, Rochester, NY
⁸Emory University School of Medicine, Atlanta, GA

Riten Kumar, MD^1*, Shahina Qureshi, MD^2*, Prita Mohanty, MD^2*, Sreedhar P Rao, MD^2* and Scott T. Miller, MD²

¹Pediatric Hematology Oncology, Mayo Clinic, Rochester, MN
²SUNY - Brooklyn, Brooklyn, NY

Vanessa Bourgeaux^1*, Olivier Hecquet^2*, Dominique Rigal^2*, Alain Francina^3* and Yann Godfrin^1*

¹ERYtech Pharma, Lyon, France
²Etablissement Français du Sang - Rhône-Alpes, Lyon, France
³Unité de Pathologie Moléculaire, Hôpital Edouard Herriot, Lyon, France

John B Porter^1*, Kai-Hsin Lin^2*, Dany Habr^3*, Gabor Domokos^4*, Abdel Hmissi^4* and Swee Lay Thein⁵

¹University College London, London, United Kingdom
²National Taiwan University Hospital, Taipei, Taiwan
³Novartis, East Hanover, NJ
⁴Novartis, Basel, Switzerland
⁵Kings College Hospital, London, United Kingdom

Elliott Vichinsky¹, Thomas Coates², Alexis A Thompson^3*, Françoise Bernaudin^4*, Martha Rodriguez^5*, Lisa Rojkjaer^6* and Matthew M Heeney^7*

¹Children's Hospital and Research Center Oakland, Oakland, CA
²Children's Hospital Los Angeles, Los Angeles, CA
³Children's Memorial Hospital, Chicago, IL
⁴Centre Hospitalier Intercommunal, Créteil, France
⁵Novartis, East Hanover, NJ
⁶Novartis, Basel, Switzerland
⁷Children's Hospital Boston, Boston, MA

Robert I. Liem, MD¹, Cynthia Rigsby, MD^2*, Richard J. Labotka, MD³, Andrew DeFreitas^4* and Alexis A. Thompson, MD, MPH⁵

¹Hematology, Oncology & Stem Cell Transplant, Children's Memorial Hospital, Chicago, IL
²Medical Imaging, Children's Memorial Hospital, Chicago, IL
³Univ. of Illinois at Chicago (M/C 856), Chicago, IL
⁴Cardiology, Children's Memorial Hospital, Chicago, IL
⁵Hematology-Oncology, Children's Memorial Hospital, Chicago, IL

Hussam Ghoti^1*, Orly Goitein^2*, Elie Konen^2*, Ariel Koren, MD^3*, Carina Levin^3*, Alan Berebi^4*, Pinhas Stark, MD⁵ and Eliezer Rachmilewitz, MD¹

¹Hematology, Edith Wolfson Medical Center, Holon, Israel
²Cardiovascular imaging diagnostic radiology, chaim Sheba medical center, Tel-Hashomer, Tel-Aviv, Israel
³Pediatric Hematology Unit, Ha'Emek Medical Center, Afula, Israel
⁴Hematology, Kaplan Medical Center, Rehovot, Israel
⁵Comprehensive Center of Thalassemia & Hemoglobinopathies, Institute of Hematology, Petah Tikva, Israel

Andrew D. Campbell, MD¹, Caterina Minniti, MD^2*, Sohail R Rana, MD^3*, Onyinye C. Onyekwere, MD, MS⁴, Mehdi Nouraie, MD, PhD^5*, Manuel Arteta, MD^6*, Craig Sable, MD^7*, Gregory Ensing, MD^8*, Niti Dham, MD^7*, Deepika S. Darbari^9*, Lori Luchtman-Jones, MD¹⁰, Gregory J. Kato, MD¹¹, Mark Gladwin, MD², Oswaldo Castro, MD^4* and Victor R. Gordeuk, MD⁴

¹Pediatric Hematology/Oncology, Univ. of Michigan Medical Center, Ann Arbor, MI
²Vascular Medicine Branch, NHLBI, Bethesda, MD
³Department of Pediatrics and Child Health, Howard University Hospital, Washington, DC
⁴Center for Sickle Cell Disease, Howard University Hospital, Washington, DC
⁵Center for Sickle cell Disease, Howard University Hospital, Washington, DC
⁶Pediatric Pulmonary, Univ. of Michigan Medical Center, Ann Arbor, MI
⁷Cardiology, Children's National Medical Center, Washington, DC
⁸Pediatric Cardiology, Univ. of Michigan Medical Center, Ann Arbor, MI
⁹Pediatric Hematology/Oncology, Johns Hopkins University School of Medicine, Baltimore, MD
¹⁰Hematology, Children's National Medical Center, Washington, DC
¹¹Pulmonary and Vascular Medicine Branch, NHLBI, Bethesda, MD

Jennifer Variste, BS^1*, Michael M. Dowling, MD, PhD^2* and Charles T. Quinn, MD, MS¹

¹Pediatrics, U.T. Southwestern Med. Ctr., Dallas, TX
²Pediatric Neurology, U.T. Southwestern Med. Ctr., Dallas, TX

Charles T. Quinn, MD, MS¹, Kimberly Thomas, BS^2*, Zora R. Rogers, MD¹ and George R. Buchanan, MD¹

¹Pediatrics, U.T. Southwestern Medical Center, Dallas, TX
²Pediatric Sickle Cell Program, Children's Medical Center Dallas, Dallas, TX

Simbo O Aduloju, MD^1*, Sheila Palmer, PAC^2* and James R. Eckman, MD³

¹Hematology & Oncology, Emory University School of Medicine, Atlanta, GA
²Sickle Cell, Grady Health System, Atlanta, GA
³Hematology&Oncology, Emory University, Atlanta, GA

James B Ball, MD¹, Samina Y Khan, BS^1*, Nathan JD McLaughlin, BS^1*, Rachelle Nuss², Laura Cole, RN^2* and Christopher C. Silliman, MD, PhD³

¹Research, Bonfils Blood Center, Denver, CO
²The Children's Hospital, Aurora, CO
³Bonfils Blood Center, Denver, CO

Megan Reagan^1*, Michael R. DeBaun, MD, MPH² and Melissa Frei-Jones, MD, MSCI^1*

¹Pediatrics, Washington University School of Medicine, St. Louis, MO
²Pediatrics and Genetics, Washington Univ., Saint Louis, MO

Lynn W Wynn, MSN, CPNP^1*, Lane Faughnan, RN, BSN, CCRP^2*, Daner Li, MS^3*, Winfred Wang, MD⁴, Brenda Martin, MSN, CPNP^5*, Tracy Kelly, MSN, CPNP^6*, Caroline Reed, MSN, FNP-C^7*, Phillip Seaman, PA-C^8*, Joan Marasciulo, RN^9*, Elizabeth Rackoff, RN, BSN^10*, Scott T. Miller, MD¹¹, Tally Hustace, ARNP^12*, Glenda Thomas, RN^13*, Jennifer Marshall, RN, ADN^14*, Jennifer McDuffie, MSN, CRNP^15*, MaryLou MacDermott, CRNP^16*, Ellen Debenham, RN, CCRC^17*, Mary Murphy, MSN, CNP^18*, Renee C. Rees, PhD^19* and for The BABY HUG Investigators^20*

¹Hematology, St. Jude Children's Research Hospital, Memphis, TN
²St. Jude Children's Research Hospital, TN
³Clinical Trials & Survey Corp., MD
⁴St. Jude Children's Research Hospital, Memphis, TN
⁵Children's National Medical Center, DC
⁶Duke University Medical Center, NC
⁷Howard University, DC
⁸Johns Hopkins University School of Medicine, MD
⁹Sinai Hospital of Baltimore, Baltimore, MD
¹⁰Medical University of South Carolina, SC
¹¹SUNY - Brooklyn, NY
¹²University of Miami School of Medicine, Miami, FL
¹³University of Mississippi Medical Center, MS
¹⁴Children's Medical Center of Dallas/UTSW, TX
¹⁵University of Alabama at Birmingham, AL
¹⁶Drexel University, PA
¹⁷Children's Healthcare of Atlanta, Atlanta, GA
¹⁸Wayne State University, MI
¹⁹Clinical Trials & Surveys, Corp., Baltimore, MD
²⁰Clinical Trials & Survey Corp., Baltimore, MD

Ram Kalpatthi, MD¹, Brittany Peters^1*, David Holloman^2*, Elizabeth Rackoffe^1*, Deborah Disco^1*, Sherron Jackson^1* and Miguel Abboud, MD^3*

¹Pediatric Hematology Oncology, Medical University of South Carolina, Charleston, SC
²Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC
³Children's Cancer Center of Lebanon, Beirut, Lebanon

Andrea Piccin, MD^1*, Elva Eakins, B.Sc, M.Sc^2*, Ciaran V Murphy, B.A., Mod^2*, William G Murphy, MD^2*, Corrina McMahon, MD¹ and Owen Smith, MD^1*

¹Our Lady's Children's Hospital, Dublin 12, Ireland
²Product Development, Irish Blood Transfusion Service, Dublin 8, Ireland

Beatrice E Gee, M.D.¹, Jerry M Manlove-Simmons, B.S^2*, Yao Huang, M.S.^1*, Nana Wilson, B.S.^3*, Jonathan Stiles, Ph.D.^3* and Solomon Fiifi Ofori-Acquah, PhD⁴

¹Pediatrics, Morehouse School of Medicine, Atlanta, GA
²Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, GA
³Microbiology, Biochemistry & Immunology, Morehouse School of Medicine, Atlanta, GA
⁴Aflac Cancer Center/Blood Disorders Services, Emory University, Atlanta, GA

Joan D Beckman, BS^1*, Julie V. Vineyard, BS^1*, Chunsheng Chen, PhD^1*, Julia Ngyuen, BS^1*, Michael O Nwaneri, M.D.^1*, Paul Marker, BS^1*, John D. Belcher, Ph.D.^1* and Gregory M. Vercellotti, MD²

¹Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN
²Medical School, University of Minnesota, Minneapolis, MN

Anna B Halpern, BA^1*, Jennifer JG Welch, MD², Priya Hirway, MS^3* and Anjulika Chawla, MD⁴

¹Pediatric Hematology Oncology, Alpert Medical School of Brown University, Providence, RI
²Pediatric Hematology Oncology, Hasbro Children's Hospital/Brown University, Providence, RI
³Community Health, Brown University, Providence, RI
⁴Hasbro Children Hospital, Providence, RI

Elizabeth Record, MSN, DNP^1*, Tamara New, MD^2*, Randall Brown, MD, MPH^3*, LeRoy Graham, MD^3* and R. Clark Brown, MD, PhD²

¹AFLAC Cancer Ctr. & Blood Disorders Svc., Children's Healthcare of Atlanta, Atlanta, GA
²AFLAC Cancer Ctr. & Blood Disorders Svc., Emory University and Children's Healthcare of Atlanta, Atlanta, GA
³Georgia Pediatric Pulmonary Associates, PC, Atlanta, GA

Winfred Wang, MD¹, Renee C Rees, PhD^2*, Scott T. Miller, MD³, R. Clark Brown, MD, PhD⁴, James F. Casella, MD⁵, Rathi V. Iyer, MD^6*, Ram V. Kalpathi, M.D.^7*, Judy Luden^8*, Zora R. Rogers, MD⁹, Courtney Thornberg, M.D.^10*, Robert J. Adams, MD⁷, Steven Pavlakis, MD^11* and the BABY HUG Investigators^12*

¹St. Jude Children's Research Hospital, Memphis, TN
²Clinical Trials & Surveys, Corp., Baltimore, MD
³SUNY - Brooklyn, Brooklyn, NY
⁴AFLAC Cancer Ctr. & Blood Disorders Svc., Emory University / Children's Healthcare of Atlanta, Atlanta, GA
⁵Johns Hopkins Univ. School of Med., Baltimore, MD
⁶Pediatrics, University of Mississippi Medical Center, Jackson, MS
⁷Medical University of South Carolina, Charleston, SC
⁸Medical College of Georgia, Augusta, GA
⁹Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX
¹⁰Duke University Medical Center, Durham, NC
¹¹Maimonides Medical Center, Brooklyn, NY
¹²C-TASC, Baltimore, MD

John J. Strouse, MD¹, Joshua Field, MD², Regina D. Crawford, M.D.^3* and Sophie Lanzkron, MD^4*

¹Div. of Pediatric Hematology, Johns Hopkins Univ., Baltimore, MD
²Washington University, Saint Louis, MO
³Division of Hematology, Duke University, Durham, NC
⁴Johns Hopkins Univ., Baltimore, MD

Precious Landburg, MD^1*, Erfan Nur, MD^2*, Naomi Maria^1*, Bart J. Biemond, MD, PhD³, Dees P.M. Brandjes, MD, PhD^4*, John-John Schnog, MD, PhD¹ and Ashley Duits, PhD¹

¹Red Cross Blood Bank Foundation, Curacao, Netherlands Antilles
²Internal Medicine, Slotervaart Hospital, Amsterdam, Netherlands
³Academic Medical Center, Amsterdam, Netherlands
⁴Department of Internal Medicine, Slotervaart hospital, Amsterdam, Netherlands

Tennille Presley, PhD^1*, Lauren Bain^1*, Samir Ballas, MD^2*, James Nichols, RN^3*, Hernan Sabio, MD⁴, Mark Gladwin, MD^3*, Gregory J. Kato, MD⁵ and Daniel Kim-Shapiro, PhD⁶

¹Physics, Wake Forest University, Winston Salem, NC
²Cardeza Foundation for Hematologic Research, Thomas Jefferson University, Philadelphia, PA
³Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD
⁴Pediatrics, Wake Forest Univ., Winston Salem, NC
⁵Pulmonary and Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
⁶Olin Physical Lab., Wake Forest University, Winston Salem, NC

Ferdane Kutlar, MD¹, Lee Hilliard, MD², Lina Zhuang, MD^3*, Niren Patel, MBBS^1* and Abdullah Kutlar, MD³

¹Sickle Cell Center, Medical College of Georgia, Augusta, GA
²Children's Hosp. of Alabama, The University of Alabama at Birmingham, Birmingham, AL
³Medical College of Georgia, Augusta, GA

Komal Bora^1*, Kavita Natarajan, MBBS¹, Ferdane Kutlar, MD², Hanfang Zhang, MD, PhD^2*, Hongyan Xu, PhD^2*, Betsy Clair^2*, Kathleen M McKie, MD^2* and Abdullah Kutlar, MD¹

¹Medical College of Georgia, Augusta, GA
²Sickle Cell Center, Medical College of Georgia, Augusta, GA

Damian Silbermins, MD¹, Laura M. De Castro, MD², Jude C Jonassaint, RN^2*, Shiaowen David Hsu, MD, PhD^3*, Marilyn J. Telen, MD³ and Jen-Tsan Chi, MD, PhD^4*

¹Medicine, Duke University, Durham, NC
²Comprehensive Sickle Cell Center, Clin. Director Duke Adult, Durham, NC
³Medicine, Duke University Medical Center, Durham, NC
⁴Duke Institute for Genome Science and Policy, Duke University, Durham, NC

Margaret T. Lee, MD, Tania Small, MD^*, Muhammad Amar Khan, MD^*, Erika Berman Rosenzweig, MD^*, Robyn J. Barst, MD^* and Gary M. Brittenham, MD

Columbia University, New York, NY

Alida Filippini^1*, Giorgio Malpeli^2*, Anne Janin^3*, Orah S Platt^4*, Christhope Leboeuf^3*, Aldo Scarpa^2*, Yves Beuzard^5* and Lucia De Franceschi, MD¹

¹Clinical and Experimental Med., Policlinico GB Rossi, Univ. of Verona, Verona, Italy
²Pathology, University of VErona, Verona, Italy
³Inserm 02 20, Laboratorie de Pathologie, Hopital S Louis, Paris, France
⁴Lab of Medicine, Children's Hospital, Boston, MA
⁵Lab of Hematopoietic Gene Therapy, Hopital S Louis, Paris, France

Ersi Voskaridou^1*, Antonios Bilalis^1*, Dimitrios Christoulas^2*, Konstantinos Varvagiannis^1*, Kleio Sinopoulou^1*, Eleni Plata^1*, Panagiotis Tsaftaridis^1*, Dimitris Loukopoulos^3* and Evangelos Terpos²

¹Thalassemia Center, Laikon General Hospital, Athens, Greece
²Department of Hematology & Medical Research, 251 General Air Force Hospital, Athens, Greece
³Haematology Research Laboratory, Biomedical Research Foundation, Academy of Athens, Athens, Greece

Paola Sebastiani, PhD^1*, Nadia Timofeev, MS^1*, Steven H. Hartley, MS^1*, Daniel Dworkis, BS^2*, Lindsay Farrer, PhD^3*, Clinton T. Baldwin, PhD^4*, Thomas T. Perls, MD^3* and Martin H. Steinberg, MD⁵

¹Biostatistics, Boston University School of Public Health, Boston, MA
²Boston University School of Medicine, Boston, MA
³Medicine, Boston University School of Medicine, Boston, MA
⁴Center for Human Genetics, Boston, MA
⁵Department of Medicine/Division of Hematology and Oncology, Boston University School of Medicine, Boston, MA

Vijay K Kalra, PhD^1*, Nitin Patel, PhD^1*, Caryn Gonsalves, MS^1*, Minyang Yang, PhD^2* and Punam Malik²

¹Biochemistry and Molecular Biology, USC Keck School of Medicine, Los Angeles, CA
²Div. of Experimental Hematology and Cancer Biology, Dept of Pediatrics, Cincinnati Childrens Hospital Medical Center, Cincinnati, OH