50th ASH Annual Meeting and Exposition (December 6

Monday, December 8, 2008: 1:30 PM-3:00 PM

2002-2004 - West (Moscone Center)

Moderators:

Susan B. Shurin, MD and Andrew D. Campbell, MD

1:30 PM

Effects of Pan-Selectin Antagonist GMI-1070 on the Treatment of Vaso-Occlusion in Sickle Cell Mice

Jungshan Chang¹^*, John T Patton²^*, Paul S. Frenette¹ and John L. Magnani²^*

¹Department of Medicine and Immunology Institute, Mount Sinai School of Medicine, New York, NY
²GlycoMimetics, Inc, Gaithersburg, MD

1:45 PM

536

Pomalidomide Augments Erythropoiesis and Fetal Hemoglobin Production in a Humanized Mouse Model of Sickle Cell Disease

Steffen E. Meiler¹, Marlene Wade¹^*, Zhong Chen¹^*, Preetha Ramalingam²^*, Laure A Moutouh-de Parseval³^*, Laura G Corral⁴, Ferdane Kutlar⁵^* and Abdullah Kutlar⁵^*

¹Anesthesiology & Periop. Med., Medical College of Georgia, Augusta, GA
²Pathology, Medical College of Georgia, Augusta, GA
³Celgene Corporation, Summit, NJ
⁴Celgene Corporation, San Diego, CA
⁵Sickle Cell Center, Medical College of Georgia, Augusta, GA

2:00 PM

537

huGTPCH Expressing S+S-Antilles Mice Have Reduced Gardos Channel Activity, Endothelin-1 Expression, and Endothelin Receptor A and B Expression, While Total Biopterin and Percent Tetrahydrobiopterin Are Increased

José R. Romero, PhD¹^*, Adriana Muniz, PhD²^*, Ashley Hale, BSc³^*, Nicholas J. Alp, PhD, DM, MRCP⁴^*, Alicia Rivera, PhD⁵, Sandra M. Suzuka, MS²^*, Keith M. Channon, MD, FRCP⁴^* and Mary E. Fabry, PhD²

¹Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital/Harvard Medical School, Boston, MA
²Hematology, Albert Einstein College of Medicine, Bronx, NY
³Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom
⁴Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom
⁵Children's Hospital Boston, Boston, MA

2:15 PM

538

The Protein C Pathway in Human and Murine Sickle Cell Disease: Alterations in Protein C, Thrombomodulin (TM), and Endothelial Protein C Receptor (EPCR) at Baseline and during Acute Vaso-Occlusion

Yihe Guo, PhD^*, Teresa Uy, MD^*, Nancy Wandersee, PhD, J. Paul Scott, MD, Hartmut Weiler, PhD, Sandra Holzhauer^*, Dawn Retherford^*, Thomas Foster^* and Cheryl Hillery, MD

Medical College of Wisconsin, Blood Research Institute, Children's Research Institute, Milwaukee, WI

2:30 PM

539

Efficient Erythroid Differentiation of a PGD-Derived Human Pluripotent Stem Cell Line Affected with Sickle Cell Hemoglobinopathy

Marina Pryzhkova, Ph.D.¹^*, Xuan Yuan, MD¹^*, Abhai Tripathi, PhD²^*, David Sullivan, MD²^* and Elias Zambidis, MD, PhD¹

¹Institute of Cell Engineering, Stem Cell Biology Program, Johns Hopkins School of Medicine, Baltimore, MD
²Malaria Research Institute, Johns Hopkins University School of Public Health, Baltimore, MD

2:45 PM

540

High Resolution Tertiary and Quaternary Structural Changes in Deoxy and Liganded Hemoglobin E

Rhoda Elison Hirsch, PhD, Vladimir Malashkevich^*, Tatiana C. Balazs^* and Steven C. Almo^*

Albert Einstein College of Med., Bronx, NY

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^*signifies non-member of ASH

111.O2.6 SCD Model Systems