50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): SCD Inflammation and Thrombosis

Sunday, December 7, 2008: 4:30 PM-6:00 PM

2002-2004 - West (Moscone Center)

Moderators:

Cheryl Hillery, MD and John J. Strouse, MD

4:30 PM

Sickle Cell Mice with Hypoxia-Reoxygenation Have Oxidative and Inflammatory Liver Injury - toward a New Experimental Model for Vaso-Occlusive Injury

Lewis L. Hsu, MD, PhD¹^*, Sruti Shiva, PhD²^*, Caroline Mendelsohn³^*, Michael R Hsu²^*, Audrey C Noguchi²^*, Laurel Mendelsohn²^* and Mark Gladwin, MD²

¹Drexel University College of Medicine, Marian Anderson Comprehensive Sickle Cell Center, Nelson 2130, Philadelphia, PA
²Vascular Medicine Branch, NHLBI, Bethesda, MD
³Clinical Center, National Institutes of Health, Bethesda, MD

4:45 PM

122

A New Model of Acute Sickle Cell Vaso-Occlusion Elicited by IgG-Mediated Hemolytic Transfusion Reactions

Jung-Eun Jang¹^*, Eldad A. Hod, MD²^*, Anna Peired, MD³^*, Set Sokol²^*, Steven L. Spitalnik, MD²^* and Paul S. Frenette, M.D.⁴

¹Medicine and Immunology Institute, Mount Sinai School of Medicine, New York, NY
²Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY
³Mount Sinai School of Medicine, New York, NY
⁴Department of Medicine and Immunology Institute, Mount Sinai School of Medicine, New York, NY

5:00 PM

123

Hypocholesterolemia in a Large Sickle Cell Cohort: Correlations of Serum Lipids to Markers of Intravascular Hemolysis and Vascular Dysfunction

Suzana M. Zorca, M.D.¹, Lita A. Freeman, Ph.D.¹^*, Patricia L. Littel, R.N., B.S.N.²^* and Gregory J. Kato, M.D.²

¹Pulmonary and Vascular Medicine Branch, National Heart Lung and Blood Institute , National Institutes of Health, Bethesda, MD
²Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD

5:15 PM

124

Sickle Cell Patients Have Exagerated Autonomic Response to Transient Hypoxia

Suvimol Sangkatumvong, MS¹^*, Rachna Khanna, BS²^*, Michael Khoo, Ph.D.¹^* and Thomas D. Coates, MD²

¹Biomedical Engineering, University of Southern California, Los Angeles, CA
²Children's Hospital of LA, Los Angeles, CA

5:30 PM

125

Aldosterone Promotes Inflammation and Endothelial Cell-Sickle Cell Adhesion: Potential for a New Therapeutic Target in Sickle Cell Disease

Wilbur Aaron Lam, MD, PhD¹^*, Wendy R Hansen, PhD²^*, James Huang, MD³, William Mentzer, MD⁴, Bertram Harold Lubin, MD⁵, Frans A. Kuypers, PhD⁶ and Daniel A. Fletcher, PhD⁷^*

¹Pediatrics, Bioengineering, UCSF, UC Berkeley, Berkeley, CA
²Biophysics, UC Berkeley, Berkeley
³Pediatrics, UCSF, San Francisco, CA
⁴Pediatrics, UCSF, Larkspur, CA
⁵Research Institute, Children's Hospital Oakland, Oakland, CA
⁶Childrens Hospital Oakland Rsch. Inst., Oakland, CA
⁷Bioengineering, UC Berkeley, Berkeley, CA

5:45 PM

126

Circulating Erythrocyte-Derived Microparticles Are Associated with Coagulation Activation in Sickle Cell Disease

Eduard J. Beers van¹^*, M. C. Schaap²^*, R.J. Berckmans¹^*, R. Nieuwland¹^*, A. Sturk¹^*, J.C.M. Meijers¹^* and Bart J. Biemond, MD, PhD¹

¹Academic Medical Center, Amsterdam, Netherlands
²Academic Medical Center, Amsterdam

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^*signifies non-member of ASH

111.O1.6 SCD Inflammation and Thrombosis