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101.P1.41 Red Cell Structure/Function, Metabolism, and Survival (Including Iron) Poster I

Saturday, December 6, 2008: 5:30 PM-7:30 PM
Hall A (Moscone Center)
The Effects of 24 Hour Continuous Deferoxamine Intensification on Serum Creatinine

Dima El-Sharkawi*, Bernard Davis* and John Porter*

Department of Haematology, University College London Hospital, London, United Kingdom

Bone Marrow Iron Concentration as a Marker of Iron Accumulation and Marrow Expansion in Patients with Beta Thalassemia Major

Paola Polchi1*, Rossella Palmieri2*, Marco Andreani1*, Javid Gaziev, MD3, Cecilia Alfieri1*, Gioia De Angelis1*, Cristiano Gallucci1*, Antonella Isgro1*, Marco Marziali1*, Katia Paciaroni1*, Andrea Roveda1*, Pietro Sodani1* and Guido Lucarelli1*

1International Center for Transplantation in Thalassemia and Sickle Cell Anemia,Mediterranean Institute of Hematology, Policlinico Tor Vergata, Rome, Italy
2Laboratory Medicine, Policlinico di Tor Vergata, Roma, Italy
3Dept. of Thalassemia, Mediterranean Institute of Hematology, Rome, Italy

Characterization of the Interaction Between Diferric Transferrin and Transferrin Receptor 2 by Functional Assays and Atomic Force Microscopy (AFM)

Katsuya Ikuta, MD, PhD1, Alexandre Yersin, PhD2*, Junko Jimbo, MD, PhD1*, Takaaki Hosoki, MD1*, Motohiro Shindo, MD, PhD1*, Kazuya Sato, MD, PhD1*, Yoshihiro Torimoto, MD, PhD3, Atsushi Ikai, PhD2* and Yutaka Kohgo, MD, PhD1

1Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical College, Asahikawa, Japan
2Department of Life Science, Tokyo Institute of Technology, Yokohama, Japan
3Oncology Center, Asahikawa Medical College Hospital, Asahikawa, Japan

Changes of the Expressions of the Genes Involved in Iron Metabolism by the Iron Chelation Therapy in the Iron Overloaded Mouse Model 

Katsuya Ikuta, MD, PhD1, Yoshihiro Torimoto, MD, PhD2, Takaaki Hosoki, MD1*, Junko Jimbo, MD, PhD1*, Motohiro Shindo, MD, PhD1*, Kazuya Sato, MD, PhD1*, Takaaki Ohtake, MD, PhD1*, Katsunori Sasaki, PhD3* and Yutaka Kohgo, MD, PhD1

1Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical College, Asahikawa, Japan
2Oncology Center, Asahikawa Medical College Hospital, Asahikawa, Japan
3Department of Gastrointestinal Immunology and Regenerative Medicine, Asahikawa Medical College, Asahikawa, Japan

Vitamin B12 Handling by the Kidney, a Major Site of B12 Traffic: Normal and Abnormal Physiology

Hesham Hazin, MD1*, Kotresha Neelakantappa, MD2*, Lakshmi Ramasahayam, MD3*, Ahmed Abdel-Maksoud, MD4*, Josua Fogel, PhD5*, Søren Kragh Moestrup, MD, PhD6* and Ralph Carmel, MD7

1NY Methodist Hosptial, Brooklyn, NY
2NY Methodist Hospital, NY
3NY Methodist Hosptial, NY
4New York Methodist Hospital, NY
5Brooklyn College of City University of NY, NY
6University of Aarhus, Aarhus C, Denmark
7Weill Medical College of Cornell Univ., New York, NY

TFR2 BETA Isoform Is Differentially Produced Compared to ALFA and Has Specific Function at Young Age

Antonella Roetto, PhD1*, Rosa Maria Pellegrino, Dr1*, Ilaria Defilippi, PhD1*, Sonia Carturan, PhD2*, Enrico Bracco, PhD1*, Daniela Cilloni, MD1, Clara Camaschella, MD3 and Giuseppe Saglio, MD1*

1Dept. Of Clinical and Biological Sciences, University of Turin, Turin, Italy
2Department of Clinical and Biological Sciences, University of Turin, Orbassano,Turin, Italy
3Vita-Salute San Raffaele University and San Raffaele Scientific Institute, Milano, Italy

Determinants for Iron Overload-Related Disease in Siblings of Probands with Clinically Detected HFE Hereditary Hemochromatosis: The Hemochromatosis Family Study 

Esther M.G. Jacobs1*, Jan C.M. Hendriks2*, Herman G. Kreeftenberg Sr.3*, Richard A. de Vries4*, Joannes J.M. Marx5*, Cees Th .B. M. van Deursen6*, Anton F.H. Stalenhoef7*, Andre L.M. Verbeek8* and Dorine W. Swinkels, MD, PhD9

1Clinical Chemistry and Hematology, Radboud Univ. Nijmegen Medical Centre, Nijmegen, Netherlands
2Epidemiology and Biostatistics, Radboud Univ. Nijmegen Medical Centre
3University Medical Centre Groningen
4Rijnstate Hospital Arnhem
5University Medical Centre Utrecht
6Atrium Medical Centre Brunssum
7General Internal Medicine, Radboud Univ. Nijmegen Medical centre
8Epidemiology and Biostatistics, Radboud Univ. Nijmegen Medical centre
9Clinical Chem. 441, Radboud Univ. Nijmegen Medical centre, Nijmegen, Netherlands

Vitamin C Deficiency in Patients on Long-Term Deferasirox without Supplementation

Konstantinos Sarantos1*, Patricia Evans2*, Maciej Garbowski1*, Bernard Davis3* and John B Porter2*

1University College London Hospitals, London, United Kingdom
2University College London, London, United Kingdom
3University College Hospitals, London, United Kingdom

Iron Overload in C282Y Heterozygotes : Identification of New Rare HFE Gene Mutants and a Step Strategy for Diagnosis

Patricia Aguilar-Martinez1, Severine Cunat1*, Fabienne Becker1*, Francois Blanc2*, Marlene Nourrit3*, Philippe Pouderoux4* and Jean-Francois Schved1*

1Laboratory of Hematology, CHU DE MONTPELLIER, Montpellier, France
2Department of Internal Medicine, CHU DE MONTPELLIER, Montpellier, France
3EFS, Nimes, France
4Hepatogastroenterology, CHU NIMES, Nimes, France

Hepcidin Suppression Relative to Iron Status in Patients with Chronic Hepatitis C

Domenico Girelli1, Michela Pasino1*, Julia Goodnough2*, Elizabeta Nemeth2*, Annalisa Castagna1*, Fabiana Busti1*, Natascia Campostrini1*, Nicola Martinelli1*, Maria Guido3*, Italo Vantini4*, Roberto Corrocher1*, Tomas Ganz2 and Giovanna Fattovich4*

1Department of Clinical and Experimental Medicine, Section of Internal Medicine, University of Verona, Verona, Italy
2UCLA School of Medicine, Los Angeles, CA
3Diagnostic Sciences & Special Therapies, University of Padova
4Gastroenterology Unit, Università di Verona, Verona, Italy

*signifies non-member of ASH