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101.O3.6 Red Cell Structure/Function, Metabolism, and Survival (Including Iron) III

Monday, December 8, 2008: 1:30 PM-3:00 PM
Yerba Buena Ballroom Salon 8 (San Francisco Marriott)
Moderators:
Gary M. Brittenham, MD and John G. Conboy, PhD
1:30 PM
529
ABC-Me (ABCB10) Is Required for Erythroid Development in the Mouse Embryo and Is Protective against Mitochondrial Oxidative Stress

Brigham B Hyde1*, Alvaro A Elorza, PhD1*, Hanna K Mikkola, MD/PhD2*, Thorsten M Schlaeger, PhD3* and Orian S Shirihai, MD/PhD1

1Molecular Medicine, Boston University Medical Center, Boston, MA
2Dmcdb, UCLA
3Harvard Stem Cell Institute, Childrens Hospital/ Harvard Medical School, Boston, MA
1:45 PM
530
Abcb10 Physically Interacts with Mitoferrin1 to Enhance Its Stability for Heme Synthesis in the Erythroid Mitochondria

Wen Chen, Ph.D.1*, Liangtao Li, M.D.2*, Nathaniel B. Langer, B.A.1*, Prasad N. Paradkar, Ph.D.2*, Iman J. Schultz, Ph.D.1*, Brigham B. Hyde, B.A.3*, Orian S. Shirihai, M.D., Ph.D.3*, Jerry Kaplan, Ph.D.2* and Barry H. Paw, M.D., Ph.D.1

1Division of Hematology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA
2Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT
3Department of Medicine, Boston University School of Medicine, Boston, MA
2:00 PM
531
Stage-Specific Switches in Alternative Pre-mRNA Splicing during Late Erythropoiesis Are Conserved from Mouse to Human

Sherry Gee1*, Jonathan Villalobos1*, Miki Yamamoto, Ph.D.1*, Tyson A. Clark, Ph.D.2*, Jeong-Ah Kang, Ph.D.3*, Amittha Wickrema, PhD3, Joel Anne Chasis, MD1 and John G. Conboy, PhD1

1Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA
2Affymetrix, Inc., Santa Clara, CA
3University of Chicago, Chicago, IL
2:15 PM
532
Rsp1 Is Indispensable for mRNA Stability during Erythroid Terminal Differentiation

Meng Tian, BS1*, Dean R. Campagna2*, Nathaniel Langer3*, Seong-Kyu Choe, Ph.D.3*, Barry H. Paw, M.D., Ph.D.3, Monica J. Justice, Ph.D.4* and Mark D. Fleming5

1Pathology, Children's Hospital Boston, Boston, MA
2Pathology, Children's Hospital Boston, Harvard Medical School, Boston, MA
3Division of Hematology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA
4Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX
5Pathology, Children's Hospital Boston, Dana Faber Cancer Institute, Harvard Medical School, Boston, MA
2:30 PM
533
Differential Glucose Transporter Expression during Perinatal and Postnatal Erythropoiesis

Amelie Montel-Hagen, PhD1*, Lionel Blanc, PhD2*, Myriam Boyer-Clavel1*, Chantal Jacquet1*, Michel Vidal, PhD2*, Marc Sitbon, PhD1* and Naomi Taylor, MD, PhD1

1Institute de Genetique, Montpellier, France
2Cnrs Umr 5235, Dynamique des Interactions Membranaires et Pathologiques (DIMNP), Montpellier, France
2:45 PM
534
Endocytosis and Erythroblast Enucleation Are Linked by the Action of a Survivin-EPS15-Clathrin Complex

Ganesan Keerthivasan, MBBS, MD1, Sara Small1*, Hui Liu2*, Amittha Wickrema, PhD2 and John Crispino, PhD1

1Medicine, Hematology/Oncology, Northwestern University, Chicago, IL
2Medicine, University of Chicago, Chicago, IL
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