Before you can access ASH's online program, you must agree to the following:
Last updated January 16, 2009. Please note that this site represents the latest program changes
and differs from the print version in some details.

101.O2.6 Red Cell Structure/Function, Metabolism, and Survival (Including Iron) II

Monday, December 8, 2008: 11:00 AM-12:30 PM
2006-2008 - West (Moscone Center)
Moderators:
Gary M. Brittenham, MD and Adrianna Vlachos, MD
11:00 AM
Nramp1 Promotes Efficient Macrophage Recycling of Iron Following Phenylhydrazine-Induced Hemolytic Anemia

Shan Soe-Lin, B.Sc1*, Bill Andriopoulos Jr., B.Sc, PhD2*, Marc Andrews3*, Matthias Schranzhofer4*, Tanya Kahawita, B.Sc, M.Sc5*, Daniel Garcia Santos, B.Sc6*, Nabila Azad5*, Sameer Sadashiv Apte, B.Sc5* and Prem Ponka, MD, PhD5

1Division of Experimental Medicine, McGill University, Montreal, QC, Canada
2Program in Membrane Biology and Division of Nephrology, Harvard Medical School, Boston, MA
3Department of Molecular Genetics and Development, IRCM, Montreal, QC, Canada
4Medicine, Lady Davis Institute for Medical Research, Montreal, QC, Canada
5Lady Davis Institute for Medical Research, Jewish General Hospital, and McGill University, Montreal, QC, Canada
6Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada

11:15 AM
Regulation of  DMT1 (non IRE isoform) by MicroRNA LET-7D

Immacolata Andolfo1*, Luigia De Falco2*, Roberta Asci1*, Roberta Russo1*, Simona Colucci1*, Massimo Zollo1* and Achille Iolascon, MD, PhD1

1Università degli Studi di Napoli, "Federico II", Ceinge, scarl, Naples, Italy
2Medical Genetics - University Federico II Naples, CEINGE Scarl, Napoles, Italy

11:30 AM
In Vitro and in Vivo Abrogation of An Erythroid Iron Restriction Developmental Checkpoint by Isocitrate through a Novel Erythropoietin-Coupled Signaling Mechanism

Grant C. Bullock, Lorrie L Delehanty*, Anne-Laure Talbot*, Chante Richardson*, Kamaleldin E Elagib* and Adam Goldfarb

Department of Pathology, University of Virginia, Charlottesville, VA

11:45 AM
Iron Depleted Erythropoiesis: Slow but Effective

Toshihiko Tanno, PhD1*, Seung-Jae Noh, PhD1*, Colleen Byrnes, MS1*, Ajoy Bhupatiraju, PhD1*, Emily Riehm Meier, MD1*, Antoinette Rabel, MSN, CRNP1*, Y.Terry Lee, MS1*, Susan Leitman, MD2 and Jeffery L Miller, MD1

1Molecular Medicine Branch, NIDDK, NIH, Bethesda, MD
2Blood Services Section, Warren Grant Magnuson Clinical Center, NIH, Bethesda, MD

12:00 PM
Genetic Evidence That Sequence Variation at the β-Globin Locus Underlies Differences in Cell Hemoglobin Concentration and Cell Hydration in Single (Hbbs) Vs. Diffuse (Hbbd) Inbred Mouse Strains: Implications for Inherited Anemias

Luanne L. Peters, PhD1, Amy J. Lambert, BS1*, Shirng-wern Tsaih, PhD1*, Jordan A. Shavit, MD, PhD2*, David Ginsburg, MD3, Gary A. Churchill, PhD1* and Carlo Brugnara, MD4

1The Jackson Laboratory, Bar Harbor, ME
2University of Michigan, Ann Arbor, MI
3University of Michigan Medical School, Life Sciences Institute, Ann Arbor, MI
4The Children's Hospital, Boston, MA

12:15 PM
A Novel Evolutionary Approach Provides Hope for Limiting Future Drug Resistance in Malaria

Theresa L. Coetzer, MD, Kubendran Naidoo* and Pierre Durand*

Molecular Medicine and Haematology, Wits Medical School, Parktown, Johannesburg, South Africa

*signifies non-member of ASH