50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Red Cell Structure/Function, Metabolism, and Survival (Including Iron) II

Monday, December 8, 2008: 11:00 AM-12:30 PM

2006-2008 - West (Moscone Center)

Moderators:

Gary M. Brittenham, MD and Adrianna Vlachos, MD

11:00 AM

Nramp1 Promotes Efficient Macrophage Recycling of Iron Following Phenylhydrazine-Induced Hemolytic Anemia

Shan Soe-Lin, B.Sc¹^*, Bill Andriopoulos Jr., B.Sc, PhD²^*, Marc Andrews³^*, Matthias Schranzhofer⁴^*, Tanya Kahawita, B.Sc, M.Sc⁵^*, Daniel Garcia Santos, B.Sc⁶^*, Nabila Azad⁵^*, Sameer Sadashiv Apte, B.Sc⁵^* and Prem Ponka, MD, PhD⁵

¹Division of Experimental Medicine, McGill University, Montreal, QC, Canada
²Program in Membrane Biology and Division of Nephrology, Harvard Medical School, Boston, MA
³Department of Molecular Genetics and Development, IRCM, Montreal, QC, Canada
⁴Medicine, Lady Davis Institute for Medical Research, Montreal, QC, Canada
⁵Lady Davis Institute for Medical Research, Jewish General Hospital, and McGill University, Montreal, QC, Canada
⁶Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada

11:15 AM

416

Regulation of DMT1 (non IRE isoform) by MicroRNA LET-7D

Immacolata Andolfo¹^*, Luigia De Falco²^*, Roberta Asci¹^*, Roberta Russo¹^*, Simona Colucci¹^*, Massimo Zollo¹^* and Achille Iolascon, MD, PhD¹

¹Università degli Studi di Napoli, "Federico II", Ceinge, scarl, Naples, Italy
²Medical Genetics - University Federico II Naples, CEINGE Scarl, Napoles, Italy

11:30 AM

417

In Vitro and in Vivo Abrogation of An Erythroid Iron Restriction Developmental Checkpoint by Isocitrate through a Novel Erythropoietin-Coupled Signaling Mechanism

Grant C. Bullock, Lorrie L Delehanty^*, Anne-Laure Talbot^*, Chante Richardson^*, Kamaleldin E Elagib^* and Adam Goldfarb

Department of Pathology, University of Virginia, Charlottesville, VA

11:45 AM

418

Iron Depleted Erythropoiesis: Slow but Effective

Toshihiko Tanno, PhD¹^*, Seung-Jae Noh, PhD¹^*, Colleen Byrnes, MS¹^*, Ajoy Bhupatiraju, PhD¹^*, Emily Riehm Meier, MD¹^*, Antoinette Rabel, MSN, CRNP¹^*, Y.Terry Lee, MS¹^*, Susan Leitman, MD² and Jeffery L Miller, MD¹

¹Molecular Medicine Branch, NIDDK, NIH, Bethesda, MD
²Blood Services Section, Warren Grant Magnuson Clinical Center, NIH, Bethesda, MD

12:00 PM

419

Genetic Evidence That Sequence Variation at the β-Globin Locus Underlies Differences in Cell Hemoglobin Concentration and Cell Hydration in Single (Hbb^s) Vs. Diffuse (Hbb^d) Inbred Mouse Strains: Implications for Inherited Anemias

Luanne L. Peters, PhD¹, Amy J. Lambert, BS¹^*, Shirng-wern Tsaih, PhD¹^*, Jordan A. Shavit, MD, PhD²^*, David Ginsburg, MD³, Gary A. Churchill, PhD¹^* and Carlo Brugnara, MD⁴

¹The Jackson Laboratory, Bar Harbor, ME
²University of Michigan, Ann Arbor, MI
³University of Michigan Medical School, Life Sciences Institute, Ann Arbor, MI
⁴The Children's Hospital, Boston, MA

12:15 PM

420

A Novel Evolutionary Approach Provides Hope for Limiting Future Drug Resistance in Malaria

Theresa L. Coetzer, MD, Kubendran Naidoo^* and Pierre Durand^*

Molecular Medicine and Haematology, Wits Medical School, Parktown, Johannesburg, South Africa

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^*signifies non-member of ASH

101.O2.6 Red Cell Structure/Function, Metabolism, and Survival (Including Iron) II