50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Red Cell Structure/Function, Metabolism, and Survival (Including Iron) I

Sunday, December 7, 2008: 4:30 PM-6:00 PM

3006-3008 - West (Moscone Center)

Moderators:

Elizabeth Nemeth, PhD and Daniel Kim-Shapiro, PhD

4:30 PM

Heritability of Iron Status Phenotype in the Hemochromatosis and Iron Overload Screening (HEIRS) Family Study

C. E. McLaren¹, J. C. Barton², G. D. McLaren³, R. T. Acton⁴^*, P. C. Adams⁵^*, L. F. Henkin⁶^*, V. R. Gordeuk⁷, J. H. Eckfeldt⁸^*, C. D. Vulpe⁹^*, B. W. Harrison⁷^*, J. A. Reiss¹⁰^* and B. M. Snively⁶^*

¹University of California, Irvine, Irvine, CA
²Southern Iron Disorders Center, Birmingham, AL
³Department of Veterans Affairs Long Beach Healthcare System, Long Beach, CA
⁴University of Alabama at Birmingham, Birmingham, AL
⁵London Health Sciences Centre, London, Ontario
⁶Wake Forest University School of Medicine, Winston-Salem, NC
⁷Howard University, Washington, DC
⁸University of Minnesota, Minneapolis, MN
⁹University of California, Berkeley, Berkeley, CA
¹⁰Kaiser Permanente Center for Health Research, Portland, OR

4:45 PM

116

Impact of Compliance, Ferritin and LIC on Long-Term Trends in Myocardial T2* with Deferasirox

Maciej Garbowski¹^*, Perla Eleftheriou¹^*, Dudley Pennell²^*, Mark Tanner³^* and John B Porter⁴^*

¹University College London Hospitals, London, United Kingdom
²Royal Brompton Hospital, London, United Kingdom
³Royal Brompton Hospital, London
⁴University College London, London, United Kingdom

5:00 PM

117

Iron Chelation by Deferoxamine Induces Autophagy

Ivana De Domenico¹^*, Diane McVey Ward, PhD²^*, James P. Kushner³^* and Jerry Kaplan, Ph.D.⁴^*

¹Medicine, University of Utah, Salt Lake City, UT
²Pathology, University Of Utah, Salt Lake City
³University of Utah, Salt Lake City, UT
⁴Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT

5:15 PM

118

The Zebrafish Ortholog of Hemojuvelin Participates in Notochord and Somite Development, but Fails to Regulate Embryonic Hepcidin Expression

Yann Gibert^*, Victoria J. Lattanzi^*, Jason Holzheimer^*, Sarah F. Burnett^* and Paula G. Fraenkel

Division of Hematology/Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA

5:30 PM

119

Structural Aspects of Hepcidin-Ferroportin Binding

Gloria Preza¹^*, Augustine Fernandes, PhD²^*, Richard J. Clark, PhD³^*, David J. Craik, PhD³^*, Tomas Ganz, MD, PhD⁴ and Elizabeta Nemeth, PhD⁵

¹Cellular and Molecular Pathology, David Geffen School of Medicine, Los Angeles, CA
²Medicine, David Geffen School of Medicine, Los Angeles, CA
³Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia
⁴UCLA School of Medicine, Los Angeles, CA
⁵UCLA, Los Angeles, CA

5:45 PM

120

Results of the First International Round Robin for the Quantification of Urinary and Plasma Hepcidin: Need for Standardization

Joyce JC Kroot¹^*, Erwin HJM Kemna¹^*, Sukhvinder Bansal²^*, Mark Busbridge³^*, Natascia Campostrini⁴^*, Domenico Girelli⁴, Robert C Hider²^*, Vasiliki Koliaraki⁵^*, Avgi Mamalaki⁵^*, Gordana Olbina⁶^*, Naohisa Tomosugi⁷^*, Chris Tselepis⁸^*, Douglas G Ward⁸^*, Tomas Ganz, MD, PhD⁹, Jan CM Hendriks¹⁰^* and Dorine W. Swinkels, MD, PhD¹¹

¹Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
²Department of Pharmacy, King's College Londen, Londen, United Kingdom
³Department of Clinical Chemistry, Imperial College HealthCare NHS Trust, Hammersmith Hospital Campus, Londen, United Kingdom
⁴Department of Clinical and Experimental Medicine, Section of Internal Medicine, University of Verona, Verona, Italy
⁵Laboratory of Molecular Biology & Immunotechnology, Department of Biochemistry, Hellenic Pasteur Institute, Athens, Greece
⁶Intrinsic Life Sciences, La Jolla, CA
⁷Proteomics Research Unit, Division of Advanced Medicine, Medical Research Institute, Kanazawa Medical University, Ishikawa, Japan
⁸CRUK Institute for Cancer Studies, University of Birmingham, Birmingham, United Kingdom
⁹UCLA School of Medicine, Los Angeles, CA
¹⁰Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre
¹¹Clinical Chem. 441, Radboud Univ. Nijmegen Medical centre, Nijmegen, Netherlands

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^*signifies non-member of ASH

101.O1.6 Red Cell Structure/Function, Metabolism, and Survival (Including Iron) I